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A kind of chitosan-copper-loaded montmorillonite intercalation composite material and its preparation method and application

A composite material, chitosan technology, applied in application, drug combination, animal feed, etc., can solve the problems of antibiotic residual bacterial resistance, pig death, slow growth of pigs, etc., and achieve strong mucosal repair activity and immune regulation function Effect

Active Publication Date: 2022-04-29
SHENZHEN INST OF GUANGDONG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is generally infectious diseases caused by bacteria and viruses, including porcine epidemic diarrhea, dysentery, infectious gastroenteritis, etc. The main form of manifestation is diarrhea, accompanied by symptoms such as elevated body temperature, loss of appetite, and dehydration. It causes slow growth of pigs, decline in feed remuneration, decline in production performance, and even death of pigs, which seriously affects the economic benefits of the breeding industry
Antibiotic-dependent prevention and control strategies have resulted in serious ecological problems such as antibiotic residues and increased bacterial resistance. It is urgent to develop a green and ecological prevention and control strategy that does not rely on antibiotics

Method used

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  • A kind of chitosan-copper-loaded montmorillonite intercalation composite material and its preparation method and application
  • A kind of chitosan-copper-loaded montmorillonite intercalation composite material and its preparation method and application
  • A kind of chitosan-copper-loaded montmorillonite intercalation composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A chitosan-copper-loaded montmorillonite powder intercalation composite material adopts copper-loaded montmorillonite powder as the main material of the intercalation, uses chitosan for intercalation composite, and the molecular weight of the chitosan is 10kDa.

[0038] The preparation method comprises the following steps:

[0039] S1. Weigh 10g of montmorillonite and disperse it into 200ml of CuSO 4 (0.05mol / L) solution, and adjust the pH value to 5.5, heated to 65°C, stirred for 6 hours, centrifuged at 3000rpm for 20min to obtain a precipitate, washed 3 times with distilled water, dried overnight at 70°C, and then ground into fine powder, passed through a 300-mesh sieve, took 5g of the sieved fine powder, added 100ml of water to prepare a copper-loaded montmorillonite suspension, and left it standing overnight to fully swell the copper-loaded montmorillonite.

[0040] S2. Get 5g of chitosan, dissolve it in 100ml of water, use 2% acetic acid solution to adjust the pH ...

Embodiment 2

[0043] A chitosan-copper-loaded montmorillonite powder intercalation composite material adopts copper-loaded montmorillonite powder as the main material of the intercalation, uses chitosan for intercalation composite, and the molecular weight of the chitosan is 10kDa.

[0044] The preparation method comprises the following steps:

[0045] S1. Weigh 10 g of montmorillonite, disperse it into 200 ml of CuSO4 (0.005 mol / L) solution, adjust the pH value to 5.5, heat to 65 ° C, stir for 6 hours, centrifuge at 3000 rpm for 20 min to obtain a precipitate, wash with distilled water for 3 The second time, the precipitate was dried overnight at 70°C, then ground into a fine powder, passed through a 300-mesh sieve, 5g of the sieved fine powder was taken, and 100ml of water was added to prepare a suspension of copper-loaded montmorillonite, which was allowed to stand overnight to make the copper-loaded montmorillonite The stone is fully swollen.

[0046]S2. Get 5g of chitosan, dissolve it...

Embodiment 3

[0049] A chitosan-copper-loaded montmorillonite powder intercalation composite material adopts copper-loaded montmorillonite powder as the main material of the intercalation, uses chitosan for intercalation composite, and the molecular weight of the chitosan is 50kDa.

[0050] The preparation method comprises the following steps:

[0051] S1. Weigh 10g of montmorillonite and disperse it into 200ml of CuSO 4 (0.05mol / L) solution, and adjust the pH value to 5.5, heated to 60°C, stirred for 6 hours, centrifuged at 3000rpm for 20min to obtain a precipitate, washed 3 times with distilled water, dried overnight at 70°C, and then ground into fine powder, pass through a 300 mesh sieve, take 5g of the sifted fine powder, add 250ml of water to prepare a copper-loaded montmorillonite suspension, and let stand overnight to fully swell the copper-loaded montmorillonite.

[0052] S2. Take chitosan 5g, dissolve it in 500ml water, use 2% acetic acid solution to adjust the pH to 6, add the ch...

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Abstract

The invention discloses a chitosan-copper-loaded montmorillonite intercalation composite material, a preparation method and an application thereof. Chitosan-copper-loaded montmorillonite intercalation composite material uses copper-loaded montmorillonite powder as the main material of the intercalation, and uses chitosan for intercalation composite, wherein the copper content of copper-loaded montmorillonite powder is 0.5% ~5%, the molecular weight of chitosan is 10~50kDa. The chitosan-copper-loaded montmorillonite powder intercalation composite material disclosed by the present invention has a large specific surface area. The copper-loaded montmorillonite powder is used as the main body of the intercalation composite material, and chitosan is used for intercalation fusion, which will have antibacterial properties. Combination of chitosan with astringent, mucosal repair and immune enhancement activities and copper-loaded montmorillonite powder with adsorption, antidiarrheal and antibacterial effects makes the two synergistic and can be better used for the treatment of porcine inflammatory bowel disease Prevention and control can reduce the diarrhea rate of weaned piglets and adult pigs to 20%, and can be widely used in the field of feed additives.

Description

technical field [0001] The invention relates to the technical field of feed additives, in particular to a chitosan-copper-loaded montmorillonite intercalation composite material and a preparation method and application thereof. Background technique [0002] Porcine inflammatory bowel disease (IBD) has been prevalent in recent years. Its etiology is complicated and its prevention and control are difficult, which seriously threatens the safety of my country's pig industry. It is generally infectious diseases caused by bacteria and viruses, including porcine epidemic diarrhea, dysentery, infectious gastroenteritis, etc. The main form of manifestation is diarrhea, accompanied by symptoms such as elevated body temperature, loss of appetite, and dehydration. It causes the slow growth of pigs, the decline of feed remuneration, the decline of production performance, and even the death of pigs, which seriously affects the economic benefits of the breeding industry. Antibiotic-depend...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/30A23K50/60A23K20/163A23K20/28A23K20/20A61K33/34A61P1/00A61P29/00A61P1/12A61K31/722A61K33/06
CPCA23K50/30A23K50/60A23K20/163A23K20/28A23K20/30A61K31/722A61K33/34A61K33/06A61P1/00A61P29/00A61P1/12A61K2300/00Y02P60/87A23V2002/00A61K33/24A61K33/00A23V2250/1588A23V2250/511A23V2200/32
Inventor 巨向红雍艳红陈圣威李思东
Owner SHENZHEN INST OF GUANGDONG OCEAN UNIV
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