Preparation method of glycerin skin dressing for treating chronic skin ulcer

A chronic ulcer and glycerin technology, applied in viscous dressings, skin transplants, dressings, etc., can solve the problems of high cost, inconvenient storage, and transportation, and achieve the effect of ensuring water activity

Inactive Publication Date: 2021-06-22
山西奥瑞生物材料有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The use of conventional allogeneic skin is effective in treating skin wounds clinically, but it is inconvenient to store and transport, and it is expensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method for a glycerol skin dressing that can be used for the treatment of chronic skin ulcers, comprising the following steps:

[0024] S1: Obtain qualified donor skin and perform disinfection treatment;

[0025] S2: adding the skin sheet obtained in step S1 into physiological saline, stirring, and washing for several times;

[0026] S3: adding the skin piece treated in step S2 into medical alcohol for sealing and soaking;

[0027] S4: adding the skin slices treated in step S3 to a 50% glycerol physiological saline solution, and standing at room temperature for a specific period of time to carry out glycerolization treatment;

[0028] S5: adding the skin slices treated in step S4 to 85% glycerol saline solution, and using a constant temperature shaker to perform glycerolization treatment;

[0029] S6: Cut the skin slices processed in step S5 into samples of different specifications, seal and package them, and sterilize them by irradiation.

Embodiment 2

[0031] As a further supplementary explanation for Example 1, when the skin is taken in step S1, the thickness of the skin slice is between 0.2-0.8 mm, and the best effect is to use a skin slice with a thickness of 0.4 mm.

[0032] In step S2, when cleaning the skin slices, first put the skin slices into a sterile stainless steel tank, add physiological saline and use a sterile glass rod to agitate and clean the skin several times, and replace the normal saline after each cleaning for the next cleaning.

[0033] In step S3, when processing the skin slices, first add the skin slices into the stainless steel tank, inject medical alcohol into the sterile stainless steel tank until the skin slices are submerged, cover and seal and soak, then remove the medical alcohol in the sterile stainless steel tank , add physiological saline and use a sterile glass rod to stir and wash several times, and replace the physiological saline after each cleaning for the next cleaning.

[0034] In st...

Embodiment 3

[0039] Prepare the glycerin skin dressing according to the preparation process provided in Example 1:

[0040] S1: Take fresh qualified skin and wipe it with iodophor for disinfection, and use a drum skin machine to take skin from the skin to make a 0.4mm skin piece;

[0041] S2: Put the skin piece in a sterile stainless steel tank, add physiological saline to stir and wash it several times, and replace the physiological saline after each cleaning for the next cleaning;

[0042] S3: Put the cleaned skin in a sterile stainless steel tank, add medical alcohol with a concentration of 70% to cover the skin, cover and seal it for a specific time, remove the alcohol and add physiological saline to stir and wash it several times, each time After cleaning, replace the normal saline for the next cleaning;

[0043] S4: Place the skin piece treated in step S3 in a sterile stainless steel tank, add a 50% glycerol saline solution, and let it stand at room temperature for preliminary glyce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a glycerin skin dressing for treating chronic skin ulcer. The preparation method comprises the following steps: obtaining qualified donor skin and performing disinfection treatment; adding the obtained skin graft into normal saline, stirring, and cleaning for multiple times; adding the cleaned skin graft into medical alcohol to be sealed and soaked; adding the soaked skin graft into a glycerin normal saline solution with the concentration of 50%, and standing for a specific time at normal temperature for primary glyceridation treatment; adding the skin graft subjected to primary glycerolation treatment into a glycerin normal saline solution with the concentration of 85%, and carrying out glycerolation treatment again by utilizing a constant-temperature shaking table; and cutting the skin graft subjected to two times of glyceridation treatment into samples with different specifications, sealing and packaging, and then carrying out irradiation sterilization. According to the method, the allogeneic skin is treated through combination of glycerolation and irradiation, and the allogeneic skin can be stored and transported in a sterile mode at normal temperature.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for preparing a glycerin skin dressing that can be used for treating chronic skin ulcers. Background technique [0002] The skin is the largest organ of the human body. It is an important barrier to protect the body from radiation in the external environment and direct harm from chemicals, bacteria and viruses. At the same time, the skin also has the functions of preventing the loss of water and electrolytes in the body and regulating water and other substances in the body. The role of balance. Chronic skin ulcers caused by various reasons are not easy to heal, conventional dressing changes or autologous skin transplantation are not easy to heal, and long-term non-healing will lead to the occurrence of scar cancer. [0003] Therefore, the use of dressings to cover the wound can protect the skin wound, and at the same time provide a favorable warm environment for th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityApplications(China)
IPC IPC(8): A61F13/02A61F2/10
CPCA61F2/105A61F13/0259A61F13/0266A61F13/0289
Inventor李晶赵亚平杨婷李靖马绍英陈学英任晓琦乔玮
Owner山西奥瑞生物材料有限公司