Moisturizing cream, preparation method of moisturizing cream and collagenase inhibitor

A collagenase and moisturizing cream technology, applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve problems such as difficulty, and achieve the effects of improving skin elasticity, easy raw materials, and mild formula

Pending Publication Date: 2021-06-29
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Moisturizing cream, preparation method of moisturizing cream and collagenase inhibitor
  • Moisturizing cream, preparation method of moisturizing cream and collagenase inhibitor
  • Moisturizing cream, preparation method of moisturizing cream and collagenase inhibitor

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preparation example Construction

[0044] The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the pomegranate peel extract and the Sophora flavescens root extract are uniformly mixed in a conventional mixing manner.

[0045] Collagenase

[0046] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolis...

Embodiment

[0098] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0099] Red pomegranate peel extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0100] Sophora flavescens root extract was purchased from: Beijing Baililaisi Biochemical Co., Ltd.

Embodiment 1-5

[0106] Pomegranate peel extract and Sophora flavescens root extract are provided as collagenase inhibitors. Red pomegranate peel extract and Sophora flavescens root extract are by mass ratio 1:2 (embodiment 1), 1:1 (embodiment 2), 5:1 (embodiment 3), 12:1 (embodiment 4) , 15:1 (embodiment 5) after mixing, obtain collagenase inhibitor.

[0107] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0108] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0109] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0110] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions, the concentrations of which were 640 μg / mL, 480 μg / mL, 320 ...

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Abstract

The invention provides moisturizing cream, a preparation method of the moisturizing cream and a collagenase inhibitor. The moisturizing cream includes the collagenase inhibitor and a permeation enhancer; and based on the total mass of the moisturizing cream, the addition of the collagenase inhibitor is 0.01-10%, and the addition of the permeation enhancer is 0.01-10%. The collagenase inhibitor includes a pomegranate peel extract and a sophora angustifolia root extract; and based on the total mass of the collagenase inhibitor, the addition of the pomegranate peel extract is 51-95%, and the addition of the sophora angustifolia root extract is 5-49%. The moisturizing cream is mild in formula and can effectively improve the elasticity of skins, so that anti-aging effects can be achieved.

Description

technical field [0001] The invention relates to a moisturizing cream, a preparation method thereof and a collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the conte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/08
CPCA61K8/9789A61Q19/00A61Q19/08A61K2800/782A61K2800/5922
Inventor 杨登亮林盛杰李传茂廖浩华张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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