Developing wire and occluder with developing function
A technology of silk and functional groups, applied in the field of medical devices, can solve the problems of inconvenient delivery and release of occluders, increase the risk of surgery for patients, and only mark occluders, etc., to expand the scope of development, reduce surgical risks, and avoid foreign objects The effect of the reaction
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Embodiment approach
[0118] The first developing filament 20 starts from the grid of the first end portion 11 of the supporting body 10, extends toward the side close to the second end portion 12, first extends to the first threading portion 13, and passes through the first threading portion 13. part 13, then extend to the second threading part 14, and pass around the mesh of the second threading part 15, then extend to the second end part 12, after passing around the mesh of the second end part 12, Extend back toward the direction of the side near the first end portion 11, then extend to the third threading portion 15, pass through the grid of the third threading portion 15, extend to the fourth threading portion 16, and finally pass through The mesh around the fourth wrapping portion 16 extends back to the first end portion 11 and protrudes from the first end portion 11 . The first developing wire 20 is detachably arranged on the supporting body 10 through the above weaving method, which expands...
Embodiment 1
[0127] Example 1. Preparation of a pluggable device containing developing filament
[0128] Use poly(p-dicyclohexanone) wire to weave the "I"-shaped occluder frame, and then start from the proximal end of the occluder, pass the developing wire along the axial direction of the frame, pass through the gap in the frame, and reach the occluder The distal apex of the occluder is then passed through the gap toward the proximal end and returns to the proximal apex. The path of the developing wire is symmetrically distributed along the central axis of the occluder, and finally the end of the developing wire is exposed outside the body along the delivery system. According to the similar steps, along the axial direction of the skeleton, and in the direction forming an angle of 90 degrees with the direction of the first developing wire, the second developing wire is inserted on the skeleton, and the end of the developing wire is exposed along the conveying system to in vitro. During the...
Embodiment 2
[0129] Example 2. Hydrogel coated polypropylene developer filament
[0130] (1) Preparation of hyaluronic acid methacrylate: hyaluronic acid was dissolved in an aqueous solution (0.1 wt%), passed through a cation exchange resin, and then freeze-dried. Then dissolve in DMSO solution, add methacrylic acid anhydride equivalent to 0.2 equivalent (mass ratio) of hyaluronic acid, react for 24 hours, add chloroform to the reaction solution to precipitate, dissolve in water, dialyze in a dialysis bag, freeze-dry Hyaluronic acid methacrylate was obtained.
[0131] (2) The polypropylene wire is first soaked in a mixed aqueous solution of 5mg / mL tannic acid and 1mg / mL tungsten nanoparticles, and 1M sodium hydroxide is added to adjust the pH to 9. After soaking for 6 hours, the polypropylene wire is taken out and deionized. After washing with water three times, it was soaked in an aqueous solution (1 mg / mL) of N-(3-aminopropyl)methacrylamide hydrochloride (pH=8) for 6 hours. The polypro...
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