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Application of brusatol to preparation of medicine for treating cerebral arterial thrombosis

A technology for ischemic stroke and brucein alcohol, which is applied in the field of medicine to achieve the effects of strong clinical application value, reducing cerebral edema and reducing the volume of cerebral infarction

Inactive Publication Date: 2021-07-23
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the research and application of Brucea Brucea in the field of prevention and treatment of ischemic stroke

Method used

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  • Application of brusatol to preparation of medicine for treating cerebral arterial thrombosis
  • Application of brusatol to preparation of medicine for treating cerebral arterial thrombosis
  • Application of brusatol to preparation of medicine for treating cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Protective effects of episodes of oxodiaol on cerebral ischemia / reperfusion injury in SD (sprague-dawley) rats:

[0024] 48 rats were randomly divided into 4 groups, named control group, model group, 5 mg / kg bilocollet bitter alcohol group and 10 mg / kg bile bitter alcohol group, 12 per group.

[0025] Model group: Refer to the Longa EZ method and slightly improved the Middle Cerebralartry Occlusion (MCAO), rat focal cerebral ischemia reperfusion model. The average depth of the nylon line is 18.5 soil 0.5mm (from the ECA branches), and the nylon line is fixed, the skin is stitched, and the ingredient is stressed. After 2 hours of suture for 2 hours, do not need to be anesthetized again and cut the neck. When the puller is in the case, it indicates that the Ni dragon's head ends to reach the ICA bifunction incision, and the blood flow is re-opened. The same side of the vascular embolization Hornor and the opposite limb movement disorder are successful.

[0026] Control ...

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Abstract

The invention belongs to the technical field of medicine, and discloses application of brusatol to preparation of a medicine for treating cerebral arterial thrombosis, thereby providing a new medicine for treating cerebral arterial thrombosis. Research finds that the brusatol can obviously improve neurobehavioral disorders caused by cerebral ischemia reperfusion injury of rats, reduce the volume of cerebral infarction and relieve encephaledema of the rats suffering from cerebral ischemia. Therefore, the brusatol has the potential of becoming a medicine for preventing and treating cerebral arterial thrombosis, and has relatively high clinical application value.

Description

Technical field [0001] The present invention belongs to the field of medical technology, and more particularly to the application of bilocollegol in the preparation of drugs in the treatment of ischemic stroke. Background technique [0002] The incidence of stroke in cardiovascular disease has always been high, especially the ischemic stroke. Ischemic stroke is due to the sudden neurological defects caused by local cerebral ischemia and permanent cerebral infarction. Its common cause includes an atherosclerosis occlusion, cerebral embolization infarction, cavity cerebral infarction, and infarction caused by distal artery stenosis and cerebral blood flow. About 1 / 3 of stroke patients have died shortly after the onset, survivors caused their ability to lose their work skills or even self-care ability for sequelae and other sequelae and other sequelae. As a common disease, ischemic stroke, seriously endangering human health, affecting the quality of life of humans, and bringing heav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P9/10
CPCA61K31/366A61P9/10
Inventor 陆亚鹏王丹王雪婷朱俐
Owner NANTONG UNIVERSITY
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