12 results about "Cerebral infarcts" patented technology

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

This invention relates to the field of assistive medical device technology and discloses a cloud-based cerebral infarction rehabilitation training device, including a rehabilitation training glove. A fixed base is provided on one side of the glove, and a lifting seat is fitted onto the upper side of the fixed base. An electric push rod for driving the lifting seat to move up and down is fixed to the upper side of the fixed base. The unfolding assembly includes a bracket fixed to the upper side of the fixed base. An image acquisition module is provided on the outer wall of the bracket, and a cylinder slides on the inner wall of the bracket. An unfolding roller is fixed to the lower side of a pressure sensor. By pressing down on the palm with the unfolding roller, the hand is massaged and unfolded. Then, the controller controls the drive of the rehabilitation training glove to adjust the position of the finger sleeves. With the cooperation of the patient's right hand, the rehabilitation training glove is put on. Thus, while enabling the patient to independently wear and use the device, it also realizes the functions of hand massage and training.

The invention discloses a micro-catheter control method for an acute cerebral infarction interventional thrombectomy, which comprises the following steps: a micro-catheter control system acquires current position state information of a micro-catheter, and drives the micro-catheter to move to a target position according to preset parameters; three-dimensional position coordinates of the microcatheter are obtained in real time through an information acquisition module; the signal processing unit compares the actual position of the microcatheter with a preset target position in real time, judges whether the microcatheter reaches the preset position or not, and receives manually input adjustment parameters when it is monitored that the resistance exceeds a threshold value or the position deviates from a path; and the signal processing unit regenerates a control instruction based on the updated parameters, and drives the microcatheter to continuously move according to the corrected parameter constraint. By acquiring the illness state and blood vessel anatomical structure information of a patient, setting the parameters such as the target position and the moving path of the microcatheter and combining the three-dimensional position coordinate information acquired by the position sensor, the microcatheter can be accurately controlled to reach the target position and move according to the preset path.

The utility model belongs to the technical field of training instruments, and discloses a cerebral infarction patient lower limb rehabilitation training device which comprises a bottom plate, a supporting rod is fixedly installed on the left side of the top of the bottom plate, a movable rod is movably connected into the supporting rod in a sleeved mode, and a transverse rod is fixedly connected to the top of the right side of the movable rod. A rotating rod is hinged to the right end of the transverse rod. Through the arrangement of the cross rod, the rotating rod, the fixing frame and the inserting block, an operator pushes the whole bottom plate to the tail of a sickbed to enable the bottom plate to enter the bottom of the sickbed, at the moment, due to the fact that the inserting block is inserted into the fixing frame, the cross rod and the rotating rod can be fixed, a patient can lie on the sickbed, then the legs of the patient are lifted, and the patient can sit on the sickbed. Lower limb rehabilitation training is carried out through the trainer, the situation that training cannot be carried out due to the fact that a patient cannot stand at the initial stage of training is avoided, the use flexibility of the device is improved, and the patient can carry out rehabilitation training as soon as possible.

The invention belongs to the technical field of medicines, and discloses application of a compound BA-7 in preparation of medicines for treating and preventing cerebral infarction. Specifically, the invention discloses a pharmacological action of the p-hydroxybenzyl substituted tryptophan compound for treating cerebral infarction. Experimental results prove that the compound BA-7 has the effects of obviously reducing the volume of cerebral infarction after acute cerebral ischemia of rats and improving neural behavior defects, and is expected to become a medicine for treating inflammation-related diseases.

The invention belongs to the technical field of medicines, and discloses application of a magnolol nitrone derivative HL-3 in preparation of medicines for preventing or treating cerebral infarction. The HL-3 shows a remarkable treatment effect in both in-vitro and in-vivo experiments. In an in-vitro experiment, the HL-3 can effectively relieve damage caused by oxygen glucose deprivation / reoxygenation (OGDR) of SK-N-SH cells under the concentration of 10 micromoles (mu M), the cell survival rate is remarkably increased, and it is indicated that the HL-3 has a high neuroprotective effect. In an integral animal experiment, the HL-3 shows an obvious treatment effect on transient middle cerebral artery occlusion (tMCAO) and permanent middle cerebral artery occlusion (pMCAO) models of SD (Sprague Dawley) rats under the dosage of 1mg / kg and 10mg / kg. Specifically, the cerebral infarction volume is reduced, and the neurological function score is improved. The results show that the HL-3 is effective in various models, has wide applicability and remarkable treatment potential, and provides a new and effective drug choice for cerebral infarction treatment.

This invention belongs to the field of pharmaceutical technology and relates to platelet aggregation inhibitors, their preparation methods, and applications. This invention provides compounds of general formula I and their pharmaceutically usable salts, tautomers, and pharmaceutically usable solvates, wherein R1, R2, and n are as described in the claims and specification. This invention also provides intermediates for preparing compounds of general formula I and their pharmaceutically usable salts, tautomers, and pharmaceutically usable solvates. The compounds of general formula I of this invention, their pharmaceutically usable salts, tautomers, pharmaceutically usable solvates, or pharmaceutical compositions thereof have platelet-inhibiting activity and can be used to prepare platelet aggregation inhibitors, which can be used to treat thromboembolic diseases, especially cerebral infarction.

1. Name of the product in this design: Upper Limb Assessment and Training Rehabilitation Robot. 2. Purpose of this design: Applicable to the rehabilitation treatment of upper limb dysfunction caused by stroke (cerebral infarction, cerebral hemorrhage). 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The utility model relates to a massage device for PNF stretching, which is used for executing one of physical therapies of cerebral palsy or cerebral infarction rehabilitation by using leg massage parts capable of operating independently. The massage device comprises a body massage part, a shaft and a plurality of leg massage parts, the leg massage part comprises any one leg massage part for massaging the legs on one side of the user and the rest leg massage part for massaging the legs on the other side of the user; the control unit performs control so as to execute at least one of: an isotonic motion that guides a direction in which a user applies a force to a leg to a direction opposite to an operation direction of the leg massage unit in a state in which the leg massage unit is operated, and an isometric motion that guides a direction in which the user applies the force to the leg to a direction opposite to the operation direction of the leg massage unit; when the leg massage part is not operated, equal-length movement in the direction in which the user applies force to the legs is guided. According to the massage device disclosed by the utility model, the reaction training for promoting or inhibiting a neuromuscular mechanism is matched with each muscle to induce proper isotonic contraction and isometric contraction, so that the muscle strength can be improved, the balanced muscle development can be realized, the joint stability can be improved, and the movable range can be expanded.

The invention discloses a marker combination for predicting the mortality risk of a patient suffering from acute ischemic cerebral infarction after etiotyping and thrombus extraction and application of the marker combination, and relates to the technical field of medical treatment. The key points of the technical scheme are as follows: the application of the marker in pathogenesis typing of the acute ischemic cerebral infarction patient and / or prediction of the death risk of the acute ischemic cerebral infarction patient after thrombus extraction is provided; the marker is a protein combination ML15 which comprises AGER, TNFRSF13B, CRIM1, ESM1, LAMP3, PRELP, LY6D, IL17D, CNTNAP2, EPO, CLSTN2, NTF3, GAL, OMD and MATN2; the effects of realizing high-precision prediction of the death risk of the patient within one year after thrombectomy, providing a key window for early intervention and analyzing pathogenesis are achieved.

The invention discloses a cerebral infarction patient limb rehabilitation training device which comprises a plurality of fixing gaskets which are sequentially connected in series, two pairs of elastic bandages are symmetrically arranged at the bottom ends of the fixing gaskets, a traction rope is arranged between the fixing gaskets, and an auxiliary rope and a connecting rope are oppositely distributed between the fixing gaskets. The auxiliary rope and the connecting rope are located on the left side and the right side of the traction rope respectively. By arranging the traction rope, the auxiliary rope and the connecting rope, when the hand of a patient has uncontrollable spasm motion, twisting force generated by finger spasm is transmitted to the traction rope and the auxiliary rope of the nearest finger in the direction from the thumb to the little finger in sequence, so that the motion amplitude of the fingers of the patient during uncontrollable spasm can be weakened, and the patient can feel more comfortable. Meanwhile, the strength of spasm exercise is reduced, the problem that the fingers and knuckle areas of the patient deform excessively due to passive spasm is solved, and the safety of the patient in rehabilitation training is protected.