146 results about "Cerebral infarcts" patented technology

The invention relates to an ozagrel sodium injection and a preparation method thereof, in particular to an ozagrel sodium injection for treating acute thrombotic cerebral infarction and movement disorders concomitant with cerebral infarction, preferably injection solution and lyophilized powder injection. The ozagrel sodium injection mainly comprises ozagrel serving as an active component and sodium hydroxide and citric acid serving as auxiliary materials. Solvent in the injection solution is water for injection. Excipient in the lyophilized powder injection is mannitol and/or sorbitol which can be combined in any one or two optional medicinal proportions, or no excipient is added.

The invention provides a herba epimedii extract, in particular to a high-content herba epimedii total flavonoids extract, and the preparation method thereof mainly comprises the following steps: (1) alkali-ethanol-water is taken as a menstruum for refluxing extraction; (2) decompression and concentration are carried out; (3) pH value is adjusted; (4) macroporous resin column elution is carried out; and (5) an eluant is dried and the content of the obtained total flavonoids is over 65 percent and the content of icariin is over 20 percent. The extract can be prepared into various oral preparations according to the requirements in pharmacy, which can be hard capsules, soft capsules, conventional tablets, orally disintegrating tablets, buccal tablets, dispersible tablets, sustained-release preparations, controlled release preparations, granules, water-paste pills, dripping pills, honeyed pills, and the like. The extract and effective medicines containing the extract can be applied to preparing brain tissue protective agents, especially to preparing medicines that prevent and treat cerebral infarction, cerebral infarction sequela and other ischemic cerebrovascular diseases.

The invention discloses a traditional Chinese medicinal preparation for treating the sequela of cerebral infarction. The traditional Chinese medicinal preparation is prepared from raw astragalus, salvia, angelica, chuanxiong, gastrodia, antelope horn, earthworm, cyathula, red peony, mulberry twig, saposhnikovia, ground pine, spatholobus, silkworm, typhonium, scorpion, pangolin scales, eucommia, agkistrodon, tortoise shell, lyceum, alpinia, turtle shell and licorice which are combined to generate a synergy to effectively nourish Yin and tonify kidney, expel wind, reduce phlegm, tonify Qi, invigorate blood circulation and remove blood stasis. In the traditional Chinese medicinal preparation, the astragalus, salvia, angelica and chuanxiong are used for tonifying Qi, invigorating blood circulation and removing blood stasis; the gastrodia, antelope horn and earthworm are used for reducing phlegm and extinguishing wind, and calming liver and suppressing Yang; and the tortoise shell and turtle shell are salty in flavor and cold in nature, return in the liver channel and have the effects of simultaneously nourishing Yin and suppressing Yang, and tonifying liver and kidney. The traditional Chinese medicinal preparation is used for treating the sequela of cerebral infarction, complied with the theories of traditional Chinese medicine and modern pharmacological study, and has the advantages of remarkable therapeutic effect and suitability for popularization and application.

The invention discloses an oral preparation of ginkgo leaf total flavonoid aglycone, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total flavonoid glycosides extracted from ginkgo leaves are hydrolyzed to obtain ginkgo leaf total flavonoid aglycone which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the ginkgo leaf total flavonoid aglycone. The preparation has significant curative effects in the treatment of coronary disease, hyperpiesis, cerebral thrombosis, cerebral infarction, apoplexy, dizziness, psychosis, nephritis, bronchitis, Parkinson's disease, diabetes, tumor, leukemia and other diseases.

The invention relates to a method for establishing an artery ischemia model of a brain of a rhesus monkey and an evaluation method. The constructing method adopts the mode of directly puncturing femoral arteries of an experimental monkey to perform the intravascular interventional operation under the direct view of a digital subtraction angiography, and establishes the chronic cerebral infarctionprimate model by using a micro-catheter to block the arteries in the brain of the experimental monkey and controlling ischemia time. The model is a quite reasonable cerebral ischemia-reperfusion animal model, and the pathological characteristics of the monkey cerebral injury model established by the method are similar to clinical manifestation; and moreover, the model is stable and reliable and issuitable for all kinds of curing therapeutic research and related basic research.

The invention relates to a pharmaceutical composite, in particular to a pharmaceutical composite for treating cerebrovascular diseases and a preparation method thereof. The pharmaceutical composite is prepared from four active pharmaceutical ingredients of moschus, blumea camphor or borneol, turmeric essential oil and Cape jasmine fruit. The active ingredient of the Cape jasmine fruit in the pharmaceutical composite mainly comprises iridoid glycosides. Through pharmacological research, the result shows that the iridoid glycosides have extensive bioactivity and benefit cerebral nervous system and cardiovascular system. Through efficacy experiment, the result shows that the pharmaceutical composite has the obvious effects of alleviating the cerebral infarction of MCAT rat and improving the nervous syndrome.

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases and a preparation method of the medicament. The medicament is prepared from a ginseng extract, a red-rooted salvia root extract and a hemlock parsley extract according to a certain weight proportion, wherein the ginseng extract, the red-rooted salvia root and the hemlock parsley extract can be obtained by commercial way or extracted from medicinal materials. The medicament can be prepared to form any pharmaceutically acceptable dosage form, preferably drop pills. The medicament has effects of tonifying qi and activating blood circulation, can be used for treating cardiovascular and cerebrovascular diseases, in particular treating in acute and early recovery phase of cerebral thrombosis, cerebral ischemia, cerebral infarction and other ischemic cerebrovascular diseases.

The invention relates to a peony seed oil gel candy and a preparation method thereof. The peony seed oil gel candy is prepared from peony seed oil, gelatin, glycerol and mannitol as raw materials through proper weight proportioning so as to finally obtain the gel candy which has the effects of regulating blood sugar, blood fat and blood pressure and preventing myocardial infarction and cerebral infarction. The preparation method of the peony seed oil gel candy has the advantages of short time, low energy consumption, large treatment capacity of medicinal raw materials, less impurities, sufficient extraction of effective ingredients of the raw materials, high extraction rate, simple extraction process operation, low cost and remarkable comprehensive economic benefits. In addition, the peonyseed oil gel candy is low in calorie, fragrant and sweet in taste, simple and stable in formula and convenient to eat and carry.

The invention provides a traditional Chinese medicine composition, which consists of raw materials in the following weight portion: hirudo, gadfly, eupolyphaga, angelica, radix paeoniae rubra, ginseng, radix astragali, peach kernel, oyster, semen vaccariae, radix curcumae, rhizoma corydalis, radix bistortae, amomum fruit, and angelica dahurica. The invention also provides a traditional Chinese medicine preparation containing the composition and a method for preparing the same. The traditional Chinese medicine composition and the traditional Chinese medicine preparation are mainly used for treating cerebral apoplexy, cerebral infarction or cerebral tumor which is distinguished to belong to Qi-deficiency and blood stasis syndrome by the traditional Chinese medical science.

The invention belongs to the field of medicines, relates to application of a physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract for treating cerebral ischemia and cerebral infarction, and in particular relates to tablets, capsules, pills and other clinical common medicinal preparations and controlled-release preparations prepared by using physalis alkekengi L.var.franchetii (Mast.) Makino total saponins as a raw material. Animal experiments indicate that the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins can be used for remarkably improving behavioral symptoms caused by cerebral ischemia of a rat, reducing the size of cerebral infarction, and reducing rat encephaledema destructed by cerebral ischemia. According to the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract, the novel application of physalis alkekengi L.var.franchetii (Mast.) Makino total saponins is expanded, and a new medical resource is provided to prevention and treatment of cerebral ischemia and cerebral infarction.

The present disclosure relates to a system and a method for estimating an acute cerebral infarction onset time. The method according to the present disclosure includes at least: receiving a first image and a second image of a first patient whose acute cerebral infarction onset time is not identified; extracting an infarction area image from the second image; aligning the second image with the first image; defining an infarction area in the first image, based on a result of the alignment of the second image with the first image; extracting feature information of the first patient, from the infarction area in the first image; comparing the extracted feature information with reference data; and calculating an amount of time that has elapsed since the acute cerebral infarction onset time, based on a result of the comparison of the extracted feature information with reference data.