Pharmaceutical composition for preventing or treating neurodegenerative diseases, containing angelica gigas nakai extract or mixed extract of angelica gigas nakai and broccoli

A technology of neurodegenerative and Korean angelica, applied in the field of pharmaceutical compositions for the prevention or treatment of neurodegenerative diseases containing the Korean angelica extract or the mixed extract of Korean angelica and broccoli, can solve the problems that have not yet been achieved, and achieve Effects of prevention and treatment of neurodegenerative diseases

Inactive Publication Date: 2021-07-23
ASTROGENESIS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no news of the development of effective therapeutic agents

Method used

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  • Pharmaceutical composition for preventing or treating neurodegenerative diseases, containing angelica gigas nakai extract or mixed extract of angelica gigas nakai and broccoli
  • Pharmaceutical composition for preventing or treating neurodegenerative diseases, containing angelica gigas nakai extract or mixed extract of angelica gigas nakai and broccoli
  • Pharmaceutical composition for preventing or treating neurodegenerative diseases, containing angelica gigas nakai extract or mixed extract of angelica gigas nakai and broccoli

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: the preparation of extract

[0080] 1.1: Preparation of Korean angelica extract

[0081] 1.1.1. Preparation of 98% ethanol extract

[0082] Wash the root of Angelica gigas Nakai with water and dry it well. Dried Angelica root was crushed, 5 times the volume (500ml) of ethanol (98% (v / v) ethanol (alcohol)) was added to 100g of the resulting powder, and extracted at a temperature of 40 to 60°C for 4 hours or longer, and then filtered through a 1 μm (micron) filter, the filtrate was heated and concentrated until it became 10% by weight of the original weight. Crystalline cellulose was gradually added to the obtained concentrate, continuously concentrated, completely dried, and then pulverized to prepare Korean angelica ethanol extract powder (hereinafter referred to as AGE).

[0083] 1.1.2. Preparation of 90% ethanol extract

[0084] Wash the Korean angelica root with clean water and dry it well. Dried Angelica root was crushed, 5 times the volume (500ml...

Embodiment 2

[0089] Example 2: Neuroprotective activity test

[0090] beta-amyloid 1-42 (American Peptide, USA) and β-amyloid 42-1 (Bachem, Switzerland) was dissolved at a concentration of 37 µl / µl in sterile 0.1 M phosphate buffer (pH 7.4), and stored until the prepared solution was used. On the other hand, the 200 mg / kg Korean angelica ethanol extract (AGE) prepared in Example 1.1.1, the 400 mg / kg broccoli ethanol extract (BKE) prepared in Example 1.2, or the 200 mg / kg Korean angelica ethanol The mixture of extract (AGE) and 400mg / kg broccoli ethanol extract was dissolved in 10ml of distilled water, and then administered to the normal mice (ICR mice; body weight 18-26g, every group of 5 mice) prepared in Example 1.3 once a day mice) for 4 weeks. For comparison, administration of distilled water in an amount of 10 ml instead of the above-prepared extract was prepared as a control group. In the bregma of mice to which the extract was administered for 4 weeks, injection was performed at...

Embodiment 3

[0096] Example 3: Nerve regeneration activity test

[0097] Mice induced by genetic manipulation for Alzheimer's disease (3xTg-AD, AD triple transgenic mouse model, 12 months old, hereinafter referred to as "3X-TG mice"; THE JACKSON LABORATORY (USA); female , 4 mice in each group, weighing about 40 g). These mice gradually express plaques and tangles, and show learning and memory deficits.

[0098] 3X-TG mice prepared at the age of 12 months were orally administered for 6 weeks, wherein the 200 mg / kg Korean angelica ethanol extract (AGE) prepared in Example 1.1.1 and / or the 400 mg / kg prepared in Example 1.2 were administered orally for 6 weeks. Broccoli ethanol extract (BKE) was dissolved in 10 ml of distilled water and administered alone or in combination 6 times a week for 6 weeks. For comparison, a group administered with 10 ml of distilled water instead of the extract was prepared as a control group. The same test was performed using B6129SF2 / J mice (female; 4 mice, bod...

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Abstract

Provided is a use of an Angelica gigas Nakai extract, or a mixed extract of Angelica gigas Nakai and broccoli (Brassica oleracea var. italica), for preventing and / or treating and / or alleviating neurodegenerative diseases, protecting neuronal cells, and / or generating neuronal cells.

Description

technical field [0001] Provided are pharmaceutical compositions for preventing and / or treating neurodegenerative diseases comprising an extract of Angelica gigas Nakai or a mixed extract of Angelica gigas Nakai and broccoli (Brassica oleracea var. italica), and pharmaceutical compositions comprising Angelica gigas Nakai A pharmaceutical composition for combined administration of extracts or mixed extracts of angelica and broccoli for the prevention and / or treatment of neurological diseases. Background technique [0002] As the population ages, the prevalence and incidence of degenerative diseases are increasing. In particular, due to the aging of the global population, the number of patients suffering from dementia-related diseases is rapidly increasing. According to the data of Alzheimer's Disease International (ADI), there were about 44.35 million people with dementia in the world in 2013. 135.46 million people. In Alzheimer's disease, the most common of several types o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K36/31A61P25/28A23L33/105
CPCA23L33/105A61K36/31A61K36/232A61P25/28A61K2236/00A61K2300/00A23V2002/00
Inventor 李康宪鞠敏
Owner ASTROGENESIS CO LTD
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