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Methods of modulting cd160 function in the antigen-specific immune cell and uses thereof

An immune cell, specific technology, applied in the field of -T cells, NK-T

Pending Publication Date: 2021-11-05
阿奇洛伊斯生物制药公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, there is no published evidence of the role of CD160 on antigen-specific T cells in the control and elimination of established tumors

Method used

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  • Methods of modulting cd160 function in the antigen-specific immune cell and uses thereof
  • Methods of modulting cd160 function in the antigen-specific immune cell and uses thereof
  • Methods of modulting cd160 function in the antigen-specific immune cell and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0281] Embodiment 1. A modified antigen-specific immune cell comprising an exogenous CD160 protein on its surface, wherein the exogenous CD160 protein results in a modified antigen-specific immune cell compared to a precursor antigen-specific immune cell not comprising the exogenous CD160 protein Upregulation of antigen-specific immune cells, where the immune cells are T cells.

Embodiment approach 2

[0282] Embodiment 2. The modified antigen-specific immune cell according to embodiment 1, wherein the modified antigen-specific immune cell is selected from the group consisting of: cytotoxic αβ T cells, γδ T cells, helper T cells, tumor infiltrating T cells , Antigen-presenting cell (APC)-activated anti-tumor T cells and natural killer T cells (NK-T cells).

Embodiment approach 3

[0283] Embodiment 3. The modified antigen-specific immune cell according to embodiment 1, wherein the modified antigen-specific immune cell is a cytotoxic T cell.

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Abstract

The present invention provides modified antigen-specific immune cells expressing an exogenous CD 160 protein. In some embodiments, the modified antigen-specific immune cell further comprises a functional exogenous receptor, such as an engineered TCR or a CAR. The present invention also provides methods of modulating CD 160 activity in antigen-specific immune cells. The present invention also provides methods and pharmaceutical compositions for cancer treatment using the modified antigen-specific immune cells and the modulators of CD 160 activity described herein.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 812,897, filed March 1, 2019, the entire contents of each of which are incorporated herein by reference. [0003] Submit a sequence listing as an ASCII text file [0004] The contents of the following submitted ASCII text file are hereby incorporated by reference in their entirety: Computer Readable Form of the Sequence Listing (CRF) (File Name: 756592000240SEQLIST.TXT, Date of Record: February 24, 2020, Size: 17KB). technical field [0005] The present invention relates to methods of modulating the function of CD160 in antigen-specific immune cells, including natural and engineered antigen-specific αβ T cells and other immune cells, such as those with or without engineered antigen recognition, and uses thereof. Natural killer (NK) cells, natural killer T cells (NK-T cells), iNK-T cells, NK-T-like cells, γδT cells and macrophages. The present in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17C07K14/725A61K38/17A61P37/04A61P35/00
CPCA61P35/00C07K16/2803C07K16/2896C07K14/7051C12N5/0636C07K2317/624C12N2510/00C12N15/86A61K39/4611A61K2239/55A61K39/464492A61K39/4632A61K39/46449A61K39/4631A61K2239/57A61K39/464488A61K39/464412C12N5/0638C07K14/70503C07K2319/03C12N2740/16043A61K2039/572A61K2239/31A61K2239/38A61K38/00C12N2740/15043
Inventor 陈长征周华孙天强罗易灵董国强
Owner 阿奇洛伊斯生物制药公司
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