Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polymer vesicle, preparation method thereof and drug-loaded vesicle

A technology of polymers and vesicles, applied in the field of nanomaterials, can solve problems such as high cost, difficulty in large-scale production, complex synthesis process, etc., and achieve high safety effects

Active Publication Date: 2021-11-26
UNIV OF SCI & TECH OF CHINA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the synthesis process of polymersomes in the related art is complicated, resulting in high cost and difficulty in large-scale production
At the same time, polymersomes will have potential toxicity and non-degradability, which limits the clinical application of polymersomes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polymer vesicle, preparation method thereof and drug-loaded vesicle
  • Polymer vesicle, preparation method thereof and drug-loaded vesicle
  • Polymer vesicle, preparation method thereof and drug-loaded vesicle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Take by weighing 80 mg of polymer shown in formula (15), dissolve in 8 ml of acetone, and the concentration is 10 mg / ml;

[0091]

[0092] Prepare 100ml PBS (phosphate buffer saline) in a beaker;

[0093] Add the organic phase to the water phase drop by drop under continuous stirring, and stir at 500 rpm for 48 hours. After the organic solvent volatilizes, a polymer vesicle solution can be formed, and the polymer vesicles are obtained by lyophilization. figure 1 An electron micrograph of the polymersome prepared in Example 1 is schematically shown.

Embodiment 2

[0095] Weigh 80 mg of the polymer shown in formula (16), dissolve it in 8 ml of acetone, and the concentration is 10 mg / ml;

[0096]

[0097] Prepare 100ml of water in a beaker;

[0098] Add the organic phase to the water phase drop by drop under continuous stirring, and stir at 500 rpm for 48 hours. After the organic solvent volatilizes, a polymer vesicle solution can be formed, and the polymer vesicles are obtained by lyophilization. figure 2 An electron micrograph of the polymersome prepared in Example 2 is schematically shown.

Embodiment 3

[0100] Take by weighing 50 mg of polymer shown in formula (17), dissolve in 10 ml of acetone, and the concentration is 5 mg / ml;

[0101]

[0102] Prepare 100ml of water in a beaker;

[0103] Add the organic phase to the water phase drop by drop under continuous stirring, and stir at 500 rpm for 48 hours. After the organic solvent volatilizes, a polymer vesicle solution can be formed, and the polymer vesicles are obtained by lyophilization. image 3 Schematically showing the electron micrograph of the polymersome prepared in Example 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a polymer vesicle, a preparation method thereof and a drug-loaded vesicle. The polymer vesicle comprises a self-assembly body of a polylactic acid zwitterionic polymer, and the polylactic acid zwitterionic polymer comprises at least one of the following formula (I) and formula (II), and r is selected from any one of the following groups of hydroxyl modified C10-C20 amino acid groups, and substituted or unsubstituted glycerophosphorylcholine; r' is selected from any one of the following groups of hydroxyl-modified C5-C10 amino acid groups, substituted or unsubstituted glycerophosphorylcholine and hydroxyl-modified phosphorylcholine; and x comprises an integer greater than or equal to 1, and y and z both comprise integers greater than or equal to 0.

Description

technical field [0001] The present disclosure relates to the field of nanomaterials, in particular to a polymer vesicle, a preparation method thereof, and a drug-loaded vesicle. Background technique [0002] Vesicles are amphiphilic molecules, such as many natural synthetic surfactants and phospholipids that cannot simply associate into micelles. When dispersed in water, they spontaneously form a type of molecularly ordered assembly with a closed double-layer structure, also known as Liposomes. Commonly used in some cells to store, transport and digest cellular products and waste. [0003] The bilayer membrane structure of the vesicle makes it a drug carrier in the body, which can carry hydrophilic drugs such as amino acids, polypeptides, proteins, and nucleic acid vaccines, encapsulate the drug in the water phase inside the vesicle, or carry Oil-soluble drugs, such as the natural anticancer drug paclitaxel, superparamagnetic iron oxide nanoparticles, solubilize them in th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/34
CPCA61K9/1273A61K47/34
Inventor 张国庆胡衎
Owner UNIV OF SCI & TECH OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com