Biocompatible membrane as well as block polymer and application thereof

A biocompatible membrane and block polymer technology, applied in the field of biosensors, can solve problems such as affecting product consistency, shortening the service life of biocompatible membrane solutions, and high viscosity of biocompatible membrane solutions.

Active Publication Date: 2021-11-30
SUZHOU ZHONGXING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is a chemical cross-linking reaction in the existing biocompatible film formulations, which greatly shortens the service life of the biocompatible film solution and virtually increases the cost of the implantable continuous glucose monitoring system. Cost of production
What's more, with the increase of use time, more and more chemical cross-linking reactions, the viscosity of the biocompatible membrane solution is also increasing, which seriously affects the consistency of the product

Method used

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  • Biocompatible membrane as well as block polymer and application thereof
  • Biocompatible membrane as well as block polymer and application thereof
  • Biocompatible membrane as well as block polymer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0048] Specific embodiment: brominated polyethylene glycol is prepared by the following method:

[0049] 1) Dissolve 50 grams of polyethylene glycol in 250 milliliters of dichloromethane and 25 milliliters of triethylamine, cool to zero in an ice bath, add 4 milliliters of dibromoisobutyryl bromide dropwise, and react overnight at 30-50°C , to obtain the reaction solution;

[0050] 2) Pour the reaction solution into 2 liters of glacial ether to obtain a precipitate, wash the precipitate several times with 500 ml of glacial ether in parts by weight, and vacuum-dry at 60-80° C. for 22-26 hours to obtain brominated polyethylene glycol ; The yield was 89%.

[0051] Further optimization and adjustment of biocompatibility function can also be achieved by directly adding high-molecular-weight polymers with good hydrophilicity and high biocompatibility, that is, the components of block polymers also include polyethylene oxide, containing Copolymers of polyethylene oxide, polypropyle...

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Abstract

The invention discloses a third-generation biosensing technology, namely an electrochemical activation technology of oxidoreductase, which can be used for manufacturing various biosensors, including a glucose biosensor that can be used for an implantable continuous glucose monitoring system. The third-generation biosensing technology overcomes the defects of a first-generation biosensing technology and a second-generation biosensing technology, improves the sensitivity, the accuracy, the reproducibility, the stability, the specificity and the anti-interference capability of glucose dynamic detection, prolongs the service life of the implantable continuous glucose monitoring system and greatly reduces the cost of a glucose biosensor.

Description

technical field [0001] The invention relates to the technical field of biosensors, more specifically, it relates to biocompatible membranes, block polymers and applications thereof. Background technique [0002] Diabetes has become a common disease worldwide. According to statistics from the International Diabetes Federation, there are currently about 425 million adults suffering from diabetes worldwide, of which 116 million are in China, the largest country in the world with diabetes. For diabetics, measuring blood sugar is an essential thing every day. At present, the most common blood sugar testing equipment refers to the blood glucose meter, but blood sugar testing has great limitations, because it can only detect patients at a certain time Point blood glucose value, can not continuously monitor the patient's blood glucose level. Therefore, continuous blood glucose monitoring equipment has emerged, the most representative of which is the implantable (minimally invasive)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D153/00C08F293/00C08F220/38C08F220/10A61B5/1486
CPCC09D153/00C08F293/005C08F220/387C08F220/10A61B5/14865C08F2438/01
Inventor 沈薇
Owner SUZHOU ZHONGXING MEDICAL TECH CO LTD
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