Lactic acid biosensor

A biosensor, lactic acid technology, applied in the field of biosensors, can solve problems such as low stability, high cost, complex manufacturing process, etc., achieve high biocompatibility, simplify design and manufacture, and simplify design and manufacture.
CN113311033APending Publication Date: 2021-08-27SUZHOU ZHONGXING MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU ZHONGXING MEDICAL TECH CO LTD
Publication Date
2021-08-27

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Abstract

The invention belongs to the technical field of biosensors, and particularly relates to a lactic acid biosensor which comprises a substrate, a carbon working electrode, a carbon counter electrode, a reference electrode and a lactic acid sensing film, wherein the carbon working electrode is an aminated graphite printing electrode, the lactic acid sensing film is formed on the surface of the carbon working electrode after lactic acid oxidase for establishing an electron transfer network is chemically crosslinked by a difunctional chemical crosslinking agent, and the lactic acid oxidase for establishing the electron transfer network is prepared by modifying electrochemically activated lactic acid oxidase by a carboxylated nano material. The electrochemical activation technology of the lactate oxidase is adopted, so that the lactate oxidase can perform direct electron exchange with the electrode, the sensitivity, accuracy, reproducibility, stability, specificity and anti-interference capability of dynamic detection of lactic acid can be improved, the service life of the implantable continuous lactic acid monitoring system is prolonged, and meanwhile, the cost of the lactic acid biosensor is greatly reduced.
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Description

technical field

[0001] The invention belongs to the technical field of biosensors, in particular to a lactic acid biosensor. Background technique

[0002] Lactic acid is the final product of glucose in the process of anaerobic metabolism in the human body. The content of lactic acid in the blood is directly related to some diseases. Its accurate monitoring is of great significance for the health assessment of critically ill patients and surgical patients. In addition, lactic acid will accumulate in the human body in a state of hypoxia or excessive fatigue. For example, the normal value of lactic acid in human blood is 1.2-2.7mmol / L, but after strenuous exercise, the lactic acid in human blood can be as high as 25mmol / L. Therefore, the content of lactic acid in body fluids and tissues effectively reflects whether the local tissues of the human body are hypoxic or whether the exercise is overloaded. If it cannot be metabolized in time, it will lead to lactic acidosis, sympt...

Claims

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