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Suspension type mouthwash and preparation method thereof

A mouthwash and gellan gum technology, which can be used in oral care, pharmaceutical formulations, cosmetic preparations, etc., and can solve the problems of mouthwash precipitation and accumulation

Pending Publication Date: 2022-01-25
CHONGQING DENCARE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention intends to provide a suspension type mouthwash and its preparation method to solve the problem of stimulating the dental pulp nerves and the easy occurrence of precipitation in the mouthwash when potassium ions and probiotic powder are added to the mouthwash in the prior art. The problem

Method used

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  • Suspension type mouthwash and preparation method thereof
  • Suspension type mouthwash and preparation method thereof
  • Suspension type mouthwash and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] A preparation method of suspension type mouthwash, comprising the steps of:

[0045] Step I: Add gellan gum, humectant, pH regulator and appropriate amount of water, stir evenly, heat to a certain temperature to completely dissolve the gellan gum, and then cool to 30-50°C for later use to obtain system I;

[0046] Step II: Stir potassium nitrate, probiotics, flavoring agents, solubilizers, gelling accelerators, preservatives and an appropriate amount of water evenly to form a suspension to obtain System II;

[0047] Step III: Mix system I and system II, add essence and stir evenly, and the preparation of mouthwash is completed.

[0048] Table 1 is the embodiment and comparative example of mouthwash of the present invention. The difference between each embodiment and comparative example is only the selection and addition of raw materials. The specific parameter settings of each embodiment and comparative example are shown in the table below. Note: the unit is g, and the...

experiment example 1

[0056] Experimental Example 1: Stability Investigation

[0057] Appearance, taste and stability tests were performed on the mouthwashes prepared in the above-mentioned embodiments and comparative examples, and the results are shown in Table 2.

[0058] In the evaluation of the appearance of mouthwash, according to the gelling state of gellan gum, it can be divided into: fluid gel, that is, the mouthwash is in a weak gel state, with suspension and fluidity; plastic gel, that is, the mouthwash has become a brittle gel state , easy to break after being stressed; elastic gel, that is, the mouthwash completely becomes a gel, which is elastic and not easy to break.

[0059] In the taste evaluation of mouthwash, the testers (10 people in each group) judged whether the taste of mouthwash is sticky and refreshing. Taste evaluation criteria are: excellent: refreshing, no adverse feelings; good: slightly sticky, no other adverse feelings, acceptable; medium: obvious sticky, slightly for...

experiment example 2

[0065] Experimental Example 2: Efficacy Test for Alleviating Dentin Sensitivity

[0066] The mouthwashes prepared in the above-mentioned examples and comparative examples were clinically tested for alleviating dentin sensitivity, with 33 people in each group. All subjects received 3 routine oral examinations and dentine sensitivity tests, and at least 2 teeth of the subjects were clinically diagnosed as dentine hypersensitivity and recorded.

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Abstract

The invention relates to the field of oral care products, and discloses a suspension type mouthwash, which comprises the following raw materials in parts by mass: 8-20 parts of basic additives, 0.01-0.05 part of gellan gum, 0.1-1 part of potassium salt and 0.05-0.5 part of probiotics. The preparation method of the suspension type mouthwash comprises the following steps: I, adding the gellan gum, a humectant, a pH value regulator and a proper amount of water, performing uniform stirring, performing heating to completely dissolve the gellan gum, and performing cooling for later use to obtain a system I; II, uniformly stirring potassium nitrate, the probiotics, a flavoring agent, a solubilizer, a gelling agent, a preservative and a proper amount of water to form a suspension, so as to obtain a system II; and III, mixing the system I and the system II, adding essence, and performing uniform stirring to obtain the mouthwash. According to the formula of the mouthwash, potassium ions and the gellan gum have a synergistic effect; therefore, on one hand, the suspension property of the system can be improved, and uniform dispersion of the probiotics is ensured; and on the other hand, a good taste can be ensured while the dentin hypersensitivity can be relieved through synergistic interaction.

Description

technical field [0001] The invention relates to the field of oral care products, in particular to a suspension type mouthwash and a preparation method thereof. Background technique [0002] Dentin hypersensitivity is one of the common oral diseases with a high prevalence rate. Domestic and foreign studies have shown that 8%-57% of the adult population suffer from dentin hypersensitivity. The disease rate is as high as 72.5%-98%, and this part of the population is often plagued by dental hypersensitivity. At present, a variety of oral problems have been proven to be closely related to oral microorganisms, such as Streptococcus mutans is the main pathogenic bacteria causing dental caries, Porphyromonas gingivalis is the main pathogenic bacteria causing periodontal disease. Mouthwash is one of the ways to clean oral health. It is easy to use and can penetrate into various parts of the oral cavity. By cooperating with brushing teeth, it can inhibit the bacteria that cause bad b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/19A61K8/73A61K8/04A61Q11/00
CPCA61K8/99A61K8/19A61K8/73A61K8/044A61Q11/00A61K2800/592
Inventor 张红张旻宫敬禹陈凤邓全富邓嵘
Owner CHONGQING DENCARE CORP
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