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Application of fraxinone in preparation of medicine for treating or preventing herpes virus infection

A herpes virus infection, ash ketone technology, applied in the field of biomedicine, can solve the problem of no ash ketone prevention or treatment of herpes virus, etc., and achieves the effect of good safety

Active Publication Date: 2022-01-28
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By targeting PD-L1, ash ketone has the potential to be used in cancer immunity, but there is no report about ash ketone being used to prepare drugs for the prevention or treatment of herpes virus

Method used

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  • Application of fraxinone in preparation of medicine for treating or preventing herpes virus infection
  • Application of fraxinone in preparation of medicine for treating or preventing herpes virus infection
  • Application of fraxinone in preparation of medicine for treating or preventing herpes virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Detection Fraxinus one of anti-HSV-1 activity

[0025] 1. Experimental materials:

[0026] 1.1 cells, the virus:

[0027] Vero cells were purchased from American Type Culture Collection (ATCC). Of HSV-1 strain F (Ejercito, PM, EDKieff, and B.Roizman.1968.Characterization of herpes simplex virus strainsdiffering in their effects on social behaviour of infectedcells.J.Gen.Virol.2: 357-364), as Chinese virus resource and information center to save (China VirusResource and Bio-information Center). Ash tree ketone was purchased from John Shannon biotech company (Biochempartner).

[0028] 1.2 Reagents:

[0029] FBS and DMEM medium were purchased from GIBCO Company; Alamarblue activity detection kit available from Thermofisher company.

[0030] 1.3 Experimental equipment:

[0031] Multi-labeled microplate reader available from PerkinElmer Inc.; cell culture incubator is Thermofisher Company.

[0032] 2. Experimental Methods and Results:

[0033] 2.1 Fraxinus one cytotox...

Embodiment 2

[0048] Example 2: Detection of white wax ketone anti-HSV-2 activity

[0049] Experimental material

[0050] 1.1 cells, viruses

[0051] Vero cells were purchased from the US Mode Strip Preservation Center (ATCC). HSV-2 is G strain (Ejercito PM, Kieffed, Roizman B.Characterization of Herpes Simplex Virus Strains Differing Intheir Effect On So Cial Behavior of Infected Cells.j Gen Virol.1968; 2: 357-64.) China Virus Resources and Information Center Save (China Virus Resource and Bio-Information Center). White wax ketone is purchased from the BiochemPartner.

[0052] 1.2 reagent

[0053] DMEM medium and FBS were purchased from GIBCO; Alamarblue Active Test Kit was purchased from thermofisher.

[0054] 1.3 experimental instrument

[0055] Multi-marked microplate readers were purchased from Perkinelmer; cell incubator was the product of Thermofisher.

[0056] 2. Experimental methods and results

[0057] 2.1 Cytotoxicity of white wax ketone on Vero cells

[0058] (1) Put Vero cells 8 × ...

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PUM

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Abstract

The invention discloses application of fraxinone in preparation of a medicine for treating or preventing herpes virus infection, and belongs to the field of biological medicine. The fraxinone is found to be capable of remarkably inhibiting the generation of infectious herpes virus particles in a non-toxic range and inhibiting the replication of herpes viruses, and the fraxinone or the pharmaceutically acceptable salt thereof can be used for preparing the medicine for treating or preventing herpes virus infection. The invention provides a safe and efficient medicine with small toxic and side effects for clinical treatment of herpes viruses.

Description

Technical field [0001] The present invention relates to the field of biomedicine, and more particularly to the use of one kind of pharmaceutically ash tree one pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment or prophylaxis of herpes virus infections. Background technique [0002] Herpes virus family (Herpesviridae) are a class of enveloped, double-stranded DNA genome of the virus family. Members of the family can be widely infected animals and people, and to induce the production of the corresponding disease. Currently found in the herpes virus can infect people there are eight, including: herpes simplex virus type I (Herpes simplex virus-1, HSV-1), herpes simplex virus type II (Herpes simplex virus-2, HSV-2), varicella - zoster virus (varicella zoster virus, VZV), EB virus (Epstein-Barr virus, EBV), cytomegalovirus (cytomegalovirus, CMV), human herpes virus type VI (HHV-6), human herpes virus type VII (HHV-7) and Kaposi's herpesvirus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/75A61P31/22A61K125/00
CPCA61K31/365A61K36/75A61P31/22Y02A50/30
Inventor 蓝柯邬开朗刘芳张艳朱莹祝成亮
Owner WUHAN UNIV
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