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Preparation method and application of noninvasive dermal penetration technology transdermal absorbent containing traditional Chinese medicine effective components

A technology of transdermal absorbent and active ingredients, which is applied in the field of non-invasive dermal penetration technology for the preparation of transdermal absorbent, can solve the problems of long course of disease, easy repetition, high disability rate and the like

Pending Publication Date: 2022-02-08
HARBIN VOCATIONAL & TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to invading the hand and foot joints, other organs or tissues, such as the lungs, heart, and nervous system, can also be affected. It has the characteristics of easy recurrence, long course of disease, and high disability rate. Because RA has a high disability rate, it seriously affects patients. quality of life

Method used

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  • Preparation method and application of noninvasive dermal penetration technology transdermal absorbent containing traditional Chinese medicine effective components
  • Preparation method and application of noninvasive dermal penetration technology transdermal absorbent containing traditional Chinese medicine effective components
  • Preparation method and application of noninvasive dermal penetration technology transdermal absorbent containing traditional Chinese medicine effective components

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Take by weighing 50g of white fresh skin, 25g of Nuxychnya, and 12.5g of datura, mix and pulverize, extract 3 times with 50% ethanol solution of 8 times the amount, each time for 1 hour, collect the ethanol extract, concentrate to No alcohol.

[0032] (2) Weigh 25 g of earthworm, extract with 8 times the amount of acid water (pH value is 5), add a certain amount of absolute ethanol to adjust to 80% ethanol content, carry out alcohol precipitation, centrifuge, and take the precipitate.

[0033] (3) Mix the samples obtained in steps (1) and (2), dissolve them in methanol, apply the wet method, pass through a silica gel column, and elute with methanol:water=2:3 ratio, 6bv, collect the eluate, and concentrate , freeze-dried to obtain a freeze-dried powder, and set aside.

Embodiment 2

[0035] (1) Take by weighing 50g of fresh cortex, 25g of Nuxychnya, and 12.5g of Dajinhua, mix them and grind them, extract once with 8 times the amount of 95% ethanol solution for 2 hours each time, collect the ethanol extract, concentrate to No alcohol.

[0036] (2) Earthworm is fed according to the ratio of 1, extracted with 8 times the amount of acid water, added a certain amount of absolute ethanol to adjust the ethanol content to 80% for alcohol precipitation, centrifuged, and the precipitate is taken.

[0037] (3) Mix the samples obtained in steps (1) and (2), dissolve them in methanol, apply the wet method, pass through a silica gel column, and elute with methanol:water=2:3 ratio, 6bv, collect the eluate, and concentrate , freeze-dried to obtain a freeze-dried powder, and set aside.

Embodiment 3

[0039](1) Take by weighing 50g of white fresh skin, 25g of Nuxychnium chinensis, 12.5g of datura japonica, mix and pulverize, extract 3 times with 65% ethanol solution of 8 times the amount, each time for 2 hours, collect the ethanol extract, concentrate to No alcohol. (2) Earthworm is fed according to the ratio of 1, extracted with 8 times the amount of acid water, added a certain amount of absolute ethanol to adjust the ethanol content to 80% for alcohol precipitation, centrifuged, and the precipitate is taken.

[0040] (3) Mix the samples obtained in steps (1) and (2), dissolve them in methanol, apply the wet method, pass through a silica gel column, and elute with methanol:water=2:3 ratio, 6bv, collect the eluate, and concentrate , freeze-dried to obtain a freeze-dried powder, and set aside.

[0041] preparation of formulations

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Abstract

The invention discloses a preparation method and application of a noninvasive dermal penetration technology transdermal absorbent containing traditional Chinese medicine effective components. The transdermal absorbent comprises the following active ingredients: cortex dictamni, lumbricus, semen strychni and flos daturae extracts, an absorption transdermal patch is prepared, and the transdermal patch is stored through hair follicles. The traditional Chinese medicine transdermal absorbent has the advantages of avoiding the first-pass effect, inactivating gastrointestinal tracts, reducing the individual difference of medication and the like of a common transdermal preparation, also can achieve a long-acting slow release effect, and can maintain constant drug effect blood concentration and physiological effect within a certain time, and the cortex dictamni, the earthworm, the semen strychni and the flos daturae extract have anti-inflammatory and analgesic effects. The joint synovial tissue hyperplasia can be relieved, and the effects can be achieved in multiple aspects to treat arthritis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a transdermal absorbent thereof, in particular to a preparation method and application of a non-invasive dermal penetration technology transdermal absorbent containing active ingredients of traditional Chinese medicine. Background technique [0002] Rheumatoid arthritis is a type of long-term chronic inflammation characterized by synovitis and chronic erosive arthritis caused by an autoimmune disorder that causes the immune system to attack the joints. In addition to invading the hand and foot joints, other organs or tissues, such as the lungs, heart, and nervous system, can also be affected. It has the characteristics of easy recurrence, long course of disease, and high disability rate. Because RA has a high disability rate, it seriously affects patients. quality of life. [0003] At present, the treatment drugs for RA mainly include non-steroidal anti-inflammatory drugs (NSAIDs)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/08A61K9/127A61K47/44A61P19/02A61P37/02A61K35/62
CPCA61K36/75A61K35/62A61K36/56A61K36/81A61K9/08A61K9/0014A61K47/44A61K9/127A61P19/02A61P37/02A61K2300/00
Inventor 王磊刘贵栋叶婷姜宇
Owner HARBIN VOCATIONAL & TECHN COLLEGE
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