Combination medicine and application thereof

A drug and application technology, applied in the field of combined drugs, can solve the problems of side effects limiting the scope of use, etc.

Pending Publication Date: 2022-02-08
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the combination of chemotherapy and immunotherapy has brought certain e...

Method used

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  • Combination medicine and application thereof
  • Combination medicine and application thereof
  • Combination medicine and application thereof

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Embodiment Construction

[0042] In order to make the purpose, technical solutions and advantages of the application clearer, the technical solutions in the embodiments of the application will be clearly and completely described below in conjunction with the embodiments of the application. Obviously, the described embodiments are part of the implementation of the application. example, not all examples. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0043] 1. Reagents and Experimental Methods

[0044] 1.1 Routine cell culture

[0045] Cell line A375 (human melanoma cell line) was cultured in DMEM high glucose complete medium containing 1% double antibody (penicillin, streptomycin) and 10% FBS (fetal bovine serum);

[0046] Cell line B16F10 (mouse melanoma cell line) was cultured in RPMI-1640 medium containing 1% diabodies (penicillin, streptomyc...

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Abstract

The invention provides a combination medicine and application thereof, the combination medicine comprises a first active component and a second active component, the first active component comprises a beta receptor blocker, and the second active component comprises an inhibitor. According to the technical scheme, the beta receptor blocker in the first active component and the inhibitor in the second active component can achieve a synergistic effect, so that the combination medicine has a remarkable anti-tumor effect, namely, tumor growth is effectively inhibited, immune cells infiltrated by tumors are increased, and a potential treatment strategy is provided for tumor treatment.

Description

technical field [0001] The application relates to the technical field of medicine, in particular to a combination drug and its application. Background technique [0002] According to the technical content disclosed in the current clinical trials, the combination of chemotherapy drugs and immunotherapy can improve the anti-tumor activity, so that patients can obtain a longer survival time. Although the combination of chemotherapy and immunotherapy has brought certain effects, the side effects of chemotherapy also greatly limit its clinical application. Contents of the invention [0003] The application provides a combination drug and its use, the combination drug has a significant anti-tumor effect. [0004] In the first aspect, the present application also provides a combination drug, including: [0005] a first active ingredient comprising a beta-blocker; [0006] The second active ingredient comprises an inhibitor. [0007] In the technical solution of the present ap...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K39/395A61K31/138A61P35/00
CPCA61K45/06A61K31/138A61K39/39558A61P35/00A61K2300/00
Inventor 贺毅憬张雨李玮
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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