218results about How to "Suitable for large-scale continuous production" patented technology

The invention relates to a bio-degradable alb derivative and the related pharmaceutical combinations; wherein, the derivative introduces alkyl, or fatty acyl or deoxycholic acid in the alb skeleton to enable the amphiphilic property and form a nano-micelle by self-organization in water, and can enwrap the drugs through the double effects of the hydrophobic group, the alb molecular chain and the drugs, thereby substantially improving the drug enwrapping ability of the alb and prolonging the stability time. The excipient can be used as the carrier for organic drugs, water-insoluble drugs or dugs with poor water solubility and the carrier of amphipathic drugs, and for the administration inside the vein or muscle injection and oral administration. The preparation method of the bio-degradable alb derivative and the related pharmaceutical combinations is simple and of mature techniques, which is suitable for large scale continuous production.

The invention relates to a biodegradable amphiphilic albumin derivative and a pharmaceutical composition thereof. In the biodegradable amphiphilic albumin derivative, hydrophilic long-chain polyethyleneglycol and alkyl (acyl) group or (deoxidized) cholic acid are led to an albumin skeleton so that the amphiphilic albumin derivative is amphipathic and is self-assembled in water to form nano-micelle. The biodegradable amphiphilic albumin derivative is characterized in that medicament can be encapsulated through the double actions of a hydrophobic group and an albumin molecule chain with the medicament, and the capacity of the albumin encapsulating the medicament is markedly improved; in addition, a hydrophilic long-chain can reduce the immunogenicity of the albumin and improve the nano-micelle surface hydrophilicity so that the stability of the nano-micelle in aqueous medium can be improved and the nano-micelle has long-circulation characteristics in a body. The pharmaceutical composition of the biodegradable amphiphilic albumin derivative can be used as the carrier of organic medicament, water-insoluble or insoluble medicament and amphiphilic medicament, can be used for intravascular administration, intramuscular injection administration, oral administration, cavitary administration or external administration. The invention can be prepared with simple method and mature process and is suitable of large-scale continuous production.

The invention relates to a method for preparing mesoporous gamma-Al2O3 by a dynamic hydrothermal method, belonging to the field of preparation of inorganic porous materials. The invention aims to solve the problems that in the prior art, reaction steps are multiple, experimental conditions are difficult to control, products are incompletely crystallized, the reaction time is too long, and a static reaction does not facilitate full contact among reaction materials. The method comprises the following steps of: adding inorganic aluminum salt and a precipitating agent into surfactant solution respectively, and uniformly mixing the inorganic aluminum salt with the precipitating agent; continuously stirring the mixed solution, and performing hydrothermal treatment; and washing and calcinating obtained products after finishing the reaction, and thus obtaining the mesoporous gamma-Al2O3. The method has the advantages that: the reaction is performed more fully, the formation of alumina precursors can be simply controlled, the formation of mesoporous alumina can be effectively controlled, the crystallization time is shortened to be less than 24 hours, the preparation period is short, and the method is suitable for large-scale continuous production.

The invention relates to a preparation method of carbon nanofibers with ordered mesoporous structures and a product prepared from the carbon nanofibers. The preparation method of the carbon nanofibers comprises the following steps of firstly, preparing phenolic resin, polyvinylpyrrolidone, an amphiphilic copolymer, inorganic salts and ethanol into a solution according to a certain proportion; secondly, preparing carbon nanofiber precursors by electrostatic spinning; thirdly, curing the carbon nanofiber precursors; fourthly, performing carbonizing and acid pickling to obtain the carbon nanofibers. The method is simple in process, low in cost and suitable for large-scale continuous production. The prepared carbon fibers contain abundant ordered mesopores; pore canals are parallel to the direction of a fiber axis, the diameters of the fibers are 300 to 900nm, pore sizes can be adjustable between 3nm and 20nm, the porosity is 80 to 97 percent, and the specific surface area is 100 to 1000m<2>/g; the carbon nanofibers have potential application in aspects of capacitors, lithium batteries, catalyst carriers, drug carriers, adsorbents and the like.

The invention relates to a preparation method of a tin oxide fiber precursor and tin oxide crystal fibers. The preparation method comprises the following steps: carrying out a replacement reaction on halides of tin and potassium (sodium) acetate to synthesize the tin oxide fiber precursor which takes acetic acid as a ligand; concentrating a precursor solution to obtain a spinning solution and carrying out centrifugal silk spinning to obtain tin oxide precursor fibers; and carrying out procedures of special atmosphere pre-treatment, high-temperature heat treatment and the like on the precursor fibers to obtain the tin oxide crystal fibers. According to the preparation method, the long-diameter ratio of the tin oxide crystal fibers is greater than 1000, the tensile strength of the fibers is 0.8GPa-1.1GPa, the whiteness of the fibers is good and the color and luster of the fibers are soft. The preparation method is simple in preparation process, moderate in condition and stable in quality of fibers in batches; spinning sol does not go bad after being placed for a long time. The tin oxide crystal fibers can be applied to the fields of photocatalysis, air sensitivity, humidity sensitivity and the like. The tin oxide fiber precursor can also be used for preparing oxide thin films, nano powder and nano wires or preparing tin-containing functional materials including nano tin oxide fibers and the like by an electrostatic spinning method.

The invention relates to a continuous synthesis method of a metalorganic frame compound with a stepped hole structure. The continuous synthesis method has the following steps that 1, a continuous reaction device is erected; 2, metal salt is dispersed in a solvent A and is added into an injector of a pump I, anorganic ligand is dispersed in a solvent B and is added into an injector of a pump II, and a continuous phase is added to an injector of a pump III; 3, a heating area is heated to reach set reaction temperature; 4, the flowing speeds of the three pumps are set, and the three pumps are started; 5, a product is collected from the output end of a pipeline, the product is separated out through centrifugation or filtration, and a stepped-hole MOF material is obtained. By adopting a continuous flow s synthesis method, continuous synthesis of the stepped-hole MOF material can be achieved. A template agent and aftertreatment process are not needed in the synthesis process, the stepped-hole MOF prepared by adopting the preparation method can be up to very high space-time yield and conversion rate, straight amplification can be performed in a simple reactor number increasing mode, and the continuous synthesis method is easy to operate and suitable for large-scale continuous production.

The invention discloses a frame laminate material and application thereof in preparing a membrane electrode with a sealed frame core component. The frame laminate material has a structure of laminating a support membrane, a first adhesion layer, a frame membrane, a second adhesion layer and a protection membrane in turn. During preparing the membrane electrode with the sealed frame core component, the frame laminate is punched according to a certain rule before the preparation of an anode sealed frame and a cathode sealed frame is finished; and in the preparation process, the thickness and intensity of the frame laminate layer are enhanced in the presence of the support membrane. Therefore, the frame laminate has better processing feasibility and dimension stability; the prepared sealed frame has higher contraposition precision; and the preparation process is more easy to control. After the preparation of the sealed frame is finished, the support membrane is stripped. A catalyst layer is coated on an active region of a polymer ion exchange membrane before or after the preparation of the sealed frame so as to prepare the core component with the sealed frame; and then the core component with the sealed frame is compounded with an anode gas diffusion layer and a cathode gas diffusion layer to prepare the membrane electrode respectively.

The invention relates to a preparation method of a flexible porous carbon fiber. The method comprises the following steps that plant cellulose lines with the diameter of 0.1-2000 micrometers are thoroughly cleaned and dried; 2, the plant cellulose lines processed in the step 1 are subjected to heat treatment at 700-1500 DEG C for 1-300 min in the reducing atmosphere, and therefore the flexible porous carbon fiber is obtained. No catalyst or solvent needs to be used, the method is easy to implement and suitable for large-scale continuous production, and the obtained flexible porous carbon fiber has the good flexibility and can be bent by 360 degrees; the internal structure of the flexible porous carbon fiber has the quite high degree of graphitization, a large number of crystal lattice fringes can be seen under high resolution, and the specific surface area is quite high and can reach up to 1362 m<2>/g.

The invention provides a graphene coating type doping method, which comprises the following steps: Step 1, preparing a doping coating solution; Step 2, coating the doping solution on the target substrate surface; The cloth liquid substrate is heated for polymerization and curing to form a doped coating; step 4, soak the doped coating with deionized water and dry it; step 5, transfer and cover graphene on the doped coating to form A composite structure composed of the first doped coating and graphene in sequence. Further, the above step 1 to step 4 can also be repeated on the composite structure to form a second layer of doped coating. The beneficial effects of the present invention are: adopting coating doping process, the thickness of the doped coating is uniform and controllable, suitable for large-area "roll-to-roll" production; in addition, the doped coating itself is stable, and is located between the graphene and the target substrate Between, the doping effect is stable and long-lasting.

The invention discloses a method for preparing super-pure nitric acid. The method comprises the following steps: taking industrial nitric acid as a raw material; performing first stage filtration by a membrane filter consisting of dibenzo-18-crown-6 and solid-phase carrier composite membrane; performing second stage serial continuous rectification on the filtrate; collecting heavy waste acid and light waste acid respectively; and performing second stage filtration with the membrane filter to obtain the super-pure nitric acid serving as the target product. Upon analysis and detection, the content of each metal ion impurity is less than 1ppb, the dust particles bigger than 0.5microns are less than 5/ml and the SEMI C8 standard is met. By performing the second stage filtration with the membrane filter consisting of the dibenzo-18-crown-6 and the solid-phase carrier composite membrane, the method overcomes the disadvantage of instable quality of the product in an existing method; the method effectively improves the purity of the super-pure nitric acid product by using the second stage serial continuous rectification technology; and the super-pure nitric acid product obtained by the method has stable quality and high purity and is suitable for scale continuous production.

The invention belongs to the field of materials chemistry and in particular relates to a method for improving the dispersibility of a single-walled carbon nanotube in aqueous solution. The method comprises the following detailed steps of: dispersing a single-walled carbon nanotube purification sample in the aqueous solution of ethanol, and performing ultrasonic dispersion on the sample to uniformly suspense the sample in the solution; quickly cooling the obtained solution by using liquid nitrogen as a cooling medium and continuously supplying the cooling medium to guarantee that the cooling temperature of the sample reaches -50 to -190 DEG C; at normal temperature and under normal pressure, placing the solid sample in a closed device in which a high-speed blade rotates, wherein the rotation speed is 22,500rpm, the rotation time is 1 minute and the crushing process is repeated for 1 to 7 times; and filtering and drying the obtained sample to obtain the single-walled carbon nanotube aqueous solution with relatively good water solubility finally. In the invention, a physical method is adopted at normal temperature and under normal pressure, so that the structure of the single-walled carbon nanotube in aqueous solution is not damaged in a treatment process; the ethanol serving as a raw material is simple and available and causes no pollution to environment; and the method has the advantages of simple process and easy processing, so that the method is suitable for commercial production.

The invention discloses a method for preparing casein phosphopeptide. The method comprises the following steps of: (1) adding protease into casein to perform enzymatic hydrolysis; (2) separating out enzymatic hydrolysate namely casein phosphopeptide by using an ultrafiltration membrane; (3) desalinating the casein phosphopeptide which is produced after ultrafiltration by using a nanofiltration membrane; and (4) adding protease into trapped fluid of the ultrafiltration membrane to perform the enzymatic hydrolysis, and repeating the steps (2) and (3). The method for preparing the casein phosphopeptide is simple to operate, low in equipment requirement, high in yield and high in product quality.

The invention discloses a lactobacillus fruit juice beverage and a preparation method thereof. The lactobacillus fruit juice beverage is composed of, by mass, 5-25% of reconstituted milk, 4-10% of fruit concentrated juice, 2-13% of mango puree, 5-20% of white granulated sugar, 0.01-0.06% of vitamin C, 1-6% of highly-concentrated fermentation liquid, 0.1-0.5% of acid, 0.1-0.7% of stabilizer, 0.01-0.05% of acidity regulator and the rest water. Fruit juice content of the lactobacillus fruit juice beverage is 40-60%, so that a market gap is filled; the lactobacillus fruit juice beverage is free of layering after long-time standing, and quality guarantee period can reach 9 months. The preparation method is simple and feasible, and the lactobacillus fruit juice beverage can be made by adopting an existing production line. The preparation method can ensure the lactobacillus fruit juice beverage to be free of wall blurring and is suitable for large-scale continuous production.

The invention provides a waterproof and moisture permeable polyethylene film and a preparation method thereof. The method comprises the following steps: S1, mixing a polyethylene raw material and white oil, performing melt extrusion, casting and cooling to obtain a cast oil film, wherein the weight-average molecular weight of the polyethylene raw material is 600000-800000, and a mass ratio of thepolyethylene raw material to the white oil is 1:(1.5-2.5); S2, heating the cast oil film to 90-110 DEG C, performing asynchronous bidirectional stretching, and performing heat setting and cooling so as to obtain a bidirectional stretched oil film, wherein a longitudinal stretching ratio of bidirectional stretching is 3-5, and a transverse stretching ratio of bidirectional stretching is 5-8; and S3, performing ultrasonic extraction on the bidirectional stretched oil film, wherein the extraction agent used for ultrasonic extraction is normal hexane or dichloromethane; and drying the extracted film, thereby obtaining the waterproof and moisture permeable polyethylene film. The waterproof and moisture permeable polyethylene film disclosed by the invention has excellent waterproof property andexcellent moisture permeability, and can be applied to the fields of medical health work, protective clothing, building safety protecting and the like.

The invention relates to a production method of ultra pure electronic grade hydrochloric acid and isopropanol. The method includes: adopting an industrial grade purity reagent as the raw material, conducting chemical pretreatment and filtration, and subjecting the obtained filtrate to rectification; heating the steam in the rectification process to form superheated steam, and subjecting the superheated steam to membrane filtration by a microporous membrane to remove solid impurity particles; and cooling the steam and then performing secondary membrane filtration to remove dust particles. Through the above design, the production method of ultra pure electronic grade hydrochloric acid and isopropanol provided by the invention is applicable to large-scale continuous production of SEMI-C12 standard ultra pure electronic grade isopropanol and SEMI-C8 standard ultra pure electronic grade hydrochloric acid.

The invention discloses a surface clad layer treatment method of a copper tungsten electrical contact material for an arc extinguish chamber. The method includes the steps that the copper tungsten alloy contact material is prepared to serve as a substrate material; mechanical buffing, washing and drying are carried out; the substrate material is placed into a vacuum chamber to deposit a chromium layer, a nickel layer or a titanium layer on a base body through a chromium target, a nickel target or a titanium target under the argon atmosphere; a copper target and a tungsten target are used for codeposition of a copper-tungsten clad layer on the substrate deposited with the chromium target, the nickel target or the titanium target continuously, and a copper tungsten-tungsten clad layer with a certain film thickness is obtained; and annealing is carried out under protection of a mixed atmosphere of inert gas and hydrogen, furnace cooling is carried out, a sample is taken out, and a copper tungsten electrical contact material surface clad layer is obtained. By means of the two-phase nanoscale uniform distributed structure, the ablation uniformity can be greatly improved, the ablation pit depth is reduced, and the service life is prolonged; meanwhile, a provided nanocrystalline tungsten framework can improve the arc ablation resistant capacity. By means of the method, equipment is simple and convenient to operate, the effect is obvious, and the good industrial application prospect is achieved.

The invention discloses a halogen-free flame-retardant high-temperature-resistant polyphenyl ether alloy material and a preparation method thereof. The halogen-free flame-retardant high-temperature-resistance polyphenyl ether alloy material is prepared from the following ingredients in mass fraction: 40 to 60 parts of polyphenyl ether, 10 to 20 parts of polystyrene, 10 to 20 parts of flexibilizer,5 to 10 parts of compound flame retardant, 6 to 15 parts of thermoplastic polyimide, 2 to 5 parts of compatilizer and 0.3 part of antioxidant. According to the halogen-free flame-retardant high-temperature-resistant polyphenyl ether alloy material disclosed by the invention, processability and shock resistance are improved based on ensuring high mechanical property of polyphenyl ether, the halogen-free flame-retardant characteristic is achieved, and high temperature resistance of the alloy material is improved. The halogen-free flame-retardant high-temperature-resistance polyphenyl ether alloy material has wide application in the fields of electrical and electronical, communication photovoltaic and the like.

A cationic liposome is proportionally prepared from DOPE, DOTMA and cholesterol and can be used to encapsulate the object (adenovirus carrier) to obtain a recombinant human endostatin adenovirus-cationic liposome composition carrying the active antineoplastic genes for suppressing the growth of tumor. Its preparing process is also disclosed.

The invention discloses ice cream milk pulp, a preparation method thereof and an ice cream containing the same. The ingredients of the ice cream milk pulp comprise raw milk, sweetening agents, 24-degree palm oil, 52-degree palm oil, coconut oil, stabilizing agents, emulsifying agents and water. The preparation method comprises the steps of mixing the ingredients uniformly, and obtaining an ingredient solution; conducting pre-homogenizing, ultra high temperature sterilization, sterility homogenizing and cooling, and obtaining the ice cream milk pulp. According to the ice cream milk pulp, a part of butter oil is replaced with vegetable fat, the cholesterol content of a product is reduced, the production cost is greatly reduced as well, and the stability and sensory effect of the product are not affected on account of poor compatibility of the vegetable fat. The ice cream milk pulp is great in texture, smooth to taste, outstanding in flavor and good in liquidity and stability, the guarantee period can reach nine months under the normal temperature condition, and the ice cream prepared with the same is uniform in state, good in firmness, ideal in expansion rate, smooth to taste and good in flavor.

The invention discloses a preparation method for a novel welding-resistant ablation-resistant Cu-nano Al2O3-Cr contact material, and belongs to the technical field of Cu-Cr contact materials. According to the alloy components, dispersion-strengthened Cu-Al2O3 powder with the content of Al2O3 being 1.2wt% and Cr powder are mixed according to the proportion of the content of Cr being 5-50wt%; and the mixture is subjected to powder mixing, primary pressing, sintering, secondary pressing and secondary sintering. The technical process is greatly simplified, the parameters are stable and reliable, the whole process is easy to control, and the preparation method is suitable for large-scale continuous production. The Cu-nano Al2O3-Cr contact material prepared through the technology is good in compactness and high in electrical conductivity, and the hardness is improved by about 25HV compared with a contact material manufactured in the prior art. The Cr particles are evenly distributed in the dispersion-strengthened Cu base body, the softening temperature of the Cu-nano Al2O3-Cr contact material is above 950 DEG C, and the novel welding-resistant ablation-resistant Cu-nano Al2O3-Cr contact material has high welding resistance and ablation resistance.