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Collagen dressing and preparation method thereof

A sticking and collagen technology, which is applied in the field of preparation of sterile collagen dressings, can solve the problems of high production requirements, high level of cytotoxicity, and decline in product quality, and achieve the effect of low requirements and low cytotoxicity

Inactive Publication Date: 2022-04-12
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, medical collagen has strict requirements on microbial limit and cytotoxicity, but existing products either have high production requirements, or are prone to high levels of cytotoxicity
For example, patent CN 105983094 A discloses a preparation process of collagen dressing, which adopts the freezing and irradiation process after filling collagen solution, but due to the long freezing and irradiation time, this process needs to ensure that the collagen stock solution is sterile, otherwise the actual A large number of microorganisms are prone to grow during the production process, resulting in a decline in product quality

Method used

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  • Collagen dressing and preparation method thereof
  • Collagen dressing and preparation method thereof
  • Collagen dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Collagen 0.1 part

[0038] 4 parts glycerin

[0039] Methylparaben 0.01 parts

[0040] Ethylparaben 0.04 parts

[0041] Purified water 95.85 parts

[0042] Total 100 copies

[0043] refer to figure 1 ,Preparation:

[0044] 1) Swell collagen in purified water to prepare initial collagen solution;

[0045] 2) Dissolve the preservative in a mixed solution of purified water and glycerin to prepare a preservative solution;

[0046] 3) Mix the above two solutions at room temperature,

[0047] 4) The obtained collagen compound solution is filled into an aluminum foil bag containing non-woven fabric in a clean environment of class 100,000 or above, and sealed;

[0048] 5) Freeze the aluminum foil bag sealed in the previous step; put the frozen aluminum foil bag into a foam box or an incubator filled with dry ice and seal it, and then sterilize it by low-temperature irradiation. The sterilization method is cobalt 60 irradiation Bacteria, the actual received radiation do...

Embodiment 2

[0052] Collagen 0.1 part

[0053] 4 parts glycerin

[0054] Methylparaben 0.003 parts

[0055] Ethylparaben 0.015 parts

[0056] Purified water 95.882 parts

[0057] Total 100 copies

[0058] Preparation:

[0059] 1) Swell collagen in purified water to prepare initial collagen solution;

[0060] 2) Dissolve the preservative in a mixed solution of purified water and glycerin to prepare a preservative solution;

[0061] 3) Mix the above two solutions at room temperature,

[0062] 4) The obtained collagen compound solution is filled into an aluminum foil bag containing non-woven fabric in a clean environment of class 100,000 or above, and sealed;

Embodiment 3

[0064] Collagen 0.1 part

[0065] 4 parts glycerin

[0066] Methylparaben 0.003 parts

[0067] Ethylparaben 0.015 parts

[0068] Purified water 95.882 parts

[0069] Total 100 copies

[0070] Preparation:

[0071] 1) Swell collagen in purified water to prepare initial collagen solution;

[0072] 2) Dissolve the preservative in a mixed solution of purified water and glycerin to prepare a preservative solution;

[0073] 3) Mix the above two solutions at room temperature,

[0074] 4) The obtained collagen compound solution is filled into an aluminum foil bag containing non-woven fabric in a clean environment of class 100,000 or above, and sealed;

[0075]5) Freeze the aluminum foil bag sealed in the previous step; put the frozen aluminum foil bag into a foam box or an incubator filled with dry ice and seal it, and then sterilize it by low-temperature radiation. The sterilization method is cobalt 60 irradiation Bacteria, the actual received radiation dose is controlled to ...

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Abstract

The invention provides a collagen patch dressing. The collagen patch dressing comprises a matrix and a collagen composite solution covering the matrix or infiltrating the matrix, the invention also provides a preparation method of the collagen dressing, which comprises the following steps of: swelling collagen in purified water to prepare a collagen initial solution, dissolving a preservative in a mixed solution of purified water and glycerol to prepare a preservative solution, mixing the two solutions under the condition of normal temperature, and uniformly stirring to obtain the collagen dressing. Filling an aluminum foil bag containing a non-woven fabric with the obtained collagen composite liquid in a clean environment of 100,000 grade or above, and sealing; freezing the aluminum foil bag sealed in the last step; and putting the frozen aluminum foil bag into a foam box or a heat preservation box filled with dry ice, sealing, carrying out low-temperature irradiation sterilization, and unfreezing to obtain the sterile collagen dressing with biological activity and quality meeting requirements. The obtained product can keep the biological activity of collagen; and the requirements on production equipment and environment are low.

Description

technical field [0001] The invention relates to a preparation method of a biologically active aseptic collagen plaster dressing, in particular to a collagen plaster dressing and a preparation method thereof. Background technique [0002] The biological activity of collagen mainly depends on its triple helical structure, which is composed of peptide chains that are no longer biologically active after collagen denaturation and unhelical. Therefore, how to ensure the invariance of collagen in the preparation process is the key to the preparation of collagen dressings. [0003] Because the collagen stock solution contains collagen, it is very easy to breed microorganisms during the production process. How to ensure the microbial level during the production process and the sterility level of the final product is the key to the process of this product. [0004] At present, medical collagen has strict requirements on microbial limit and cytotoxicity, but existing products either h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/20A61L15/42A61L15/44
Inventor 章金禄冯杰蔡蓓蕾
Owner JIANGSU SEMPOLL PHARMA
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