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Preparation method of kanamycin monosulfate soluble powder

A kanamycin monosulfate and soluble technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, powder delivery, etc., can solve the problem of rapid infection, high late recurrence rate, and poultry-prone Intestinal infection cases and other issues

Pending Publication Date: 2022-04-15
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The eating environment of poultry and the sanitation of feed are very important, but with the rapid development of the breeding industry, cases of intestinal infection of poultry are prone to occur, and they will be quickly transmitted with feces. If it is not treated in time, the mortality rate will be extremely high, causing economic losses to farmers.
[0003] At present, most of the drugs used to treat intestinal infection in the domestic veterinary drug market have no significant effect or a high recurrence rate in the later period, mainly due to strong bacterial resistance, drug oxidation, and the influence of metal ions in tap water when the drug dissolves in water. Severe intestinal damage leads to poor absorption and other reasons

Method used

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  • Preparation method of kanamycin monosulfate soluble powder
  • Preparation method of kanamycin monosulfate soluble powder
  • Preparation method of kanamycin monosulfate soluble powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Clinical Trial One

[0018] (1) Test animals

[0019] A group of 18-day-old broiler chickens were found in a chicken farm in Tianjin. The chickens were depressed and their feed intake decreased. The autopsy showed that the abdominal cavity was covered with yellow cellulose membrane, the liver and heart were enlarged, the gastrointestinal mucosa was bleeding, and the gastrointestinal mucosa had ulcers. .

[0020] (2) Test drug: the drug prepared in Example 2 of the present invention.

[0021] (3) Experimental design and methods

[0022] Randomly select 280 diseased chickens in this chicken farm, and test group 1 is the routine drug group, selects commercially available kanamycin soluble powder (specification 12%), mixed drink, every 1L water, 1.0g, uses three days in succession; Test group 2 It is the drug group of Example 2 of the present invention, mixed drink, per 1L of water, 1.2g, used continuously for three days.

[0023] (4) Efficacy Judgment Criteria

[0024...

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Abstract

The invention relates to kanamycin monosulfate soluble powder and a preparation method thereof. The medicine composition mainly comprises kanamycin monosulfate, a cosolvent PVP (which can improve the solubility of kanamycin monosulfate so as to improve the bioavailability), maltodextrin (which can improve the stability of kanamycin monosulfate) and the like. The method is simple in preparation process, low in energy consumption, low in cost and suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to a drug for treating poultry intestinal bacterial infection and a preparation method thereof. Background technique [0002] The intestinal tract is a very complex multi-functional system in the poultry body, which works organically with other systems such as the respiratory system and circulatory system of the body. The gut can provide some special mechanisms through which the body absorbs the nutrients needed for poultry growth from the gut, and at the same time protects the host through certain protective mechanisms. In addition, the intestinal tract itself can be used as a living environment for many pathogenic microorganisms. The eating environment of poultry and the sanitation of feed are very important, but with the rapid development of the breeding industry, cases of intestinal infection of poultry are prone to occur, and they will be quickly transmitted with fece...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/7036A61K47/32A61K47/36A61K47/26A61P31/04A61P1/00A61P1/14A61P3/02A61P37/04
Inventor 李新逯荷香李阳
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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