Rotary microfluidic device and method for controllably preparing monodisperse emulsion

Abstract

The invention provides a rotary micro-fluidic device capable of controllably preparing monodisperse emulsion. The rotary micro-fluidic device comprises a rotary platform, an injection tube, a collection container and an injection pump, the rotating platform comprises a motor and a horizontally-arranged rotating disc. The motor drives the rotating disc to rotate around the circle center of the rotating disc at a constant speed. The collecting container is horizontally fixed on the turntable, and the circle center of the collecting container coincides with the circle center of the turntable; an inlet of the injection pipe is communicated with the injection pump, and an outlet of the injection pipe is located outside the circle center of the collecting container and below the liquid level of fluid contained in the collecting container. The invention further provides a controllable preparation method of the monodisperse emulsion on the basis of the device. The micro-fluidic device for preparing the monodisperse emulsion and the construction of the micro-fluidic device are simpler, and the preparation and yield amplification of the monodisperse emulsion are more convenient and efficient.

Description

technical field

[0001] The invention belongs to the field of emulsion preparation and relates to a microfluidic device and method for preparing monodisperse emulsion. Background technique

[0002] Emulsion plays an important role in many fields such as chemical industry, medicine, food and cosmetics. The microfluidic technology that has emerged in recent years has shown unique advantages in the controllable preparation of emulsion droplets because it can precisely control the flow and dispersion of fluids in microchannels. Microfluidic controlled milk technology usually relies on microfluidic devices with complex geometric microchannels such as coaxial co-flow, flow-focusing and cross-flow. surface modification technology. At the same time, in the microfluidic milking process, it usually involves the flow control of the dispersed phase fluid and the continuous phase fluid in different microchannels, and the shearing process of the two phase fluids at the intersection of th...

Examples

Embodiment 1

[0038] In this example, a rotary microfluidic device that can controlly prepare monodisperse emulsion is provided, and its structural schematic diagram is as follows figure 1 As shown, a rotating platform 1 , a syringe 2 , a collection container 3 and a syringe pump 4 are included.

[0039] The rotating platform 1 includes a motor and a horizontally arranged turntable, the turntable is circular, and the motor drives the turntable to rotate at a constant speed around the center of the turntable; the cross section of the collection container 3 is circular, specifically a glass petri dish with a diameter of 20 cm, and the collection container is fixed horizontally On the turntable, that is, the circular bottom surface of the petri dish is fixed horizontally on the turntable, and the center of the petri dish coincides with the center of the turntable; the motor drives the turntable to rotate at a constant speed, and then drives the collection container on the turntable and the cont...

Embodiment 2

[0042] In this embodiment, a rotary microfluidic device for controllable preparation of monodisperse emulsion is provided, including a rotary platform 1 , a syringe 2 , a collection container 3 , a syringe pump 4 and a fluid distribution plate 6 .

[0043] The rotating platform 1 includes a motor and a horizontally arranged turntable, the turntable is circular, and the motor drives the turntable to rotate at a constant speed around the center of the turntable; the cross section of the collection container 3 is circular, specifically a glass petri dish with a diameter of 20 cm, and the collection container is fixed horizontally On the turntable, that is, the circular bottom surface of the petri dish is fixed horizontally on the turntable, and the center of the petri dish coincides with the center of the turntable; the motor drives the turntable to rotate at a constant speed, and then drives the collection container on the turntable and the continuous phase fluid in the collection...

Embodiment 3

[0047] In this embodiment, the preparation process of monodisperse water-in-oil (W / O) emulsion is taken as an example to illustrate the controllable preparation method of monodisperse emulsion provided by the present invention. The steps are as follows:

[0048] (1) Preparation of dispersed phase and continuous phase fluid

[0049] Deionized water was used as the dispersed phase fluid; T154 was dissolved in soybean oil to obtain the continuous phase fluid, and the concentration of T154 in the continuous phase fluid was 0.04g / mL.

[0050] (2) Preparation of monodisperse W / O emulsion

[0051] The rotary microfluidic device described in Example 1 is used for preparation, the continuous phase fluid is contained in a petri dish, the outlet of the injection tube is controlled to be located below the liquid level of the continuous phase fluid contained in the petri dish, and the outlet of the injection tube is in contact with the petri dish The distance between the centers of the ci...

technical field

[0001] The invention belongs to the field of emulsion preparation and relates to a microfluidic device and method for preparing monodisperse emulsion. Background technique

[0002] Emulsion plays an important role in many fields such as chemical industry, medicine, food and cosmetics. The microfluidic technology that has emerged in recent years has shown unique advantages in the controllable preparation of emulsion droplets because it can precisely control the flow and dispersion of fluids in microchannels. Microfluidic controlled milk technology usually relies on microfluidic devices with complex geometric microchannels such as coaxial co-flow, flow-focusing and cross-flow. surface modification technology. At the same time, in the microfluidic milking process, it usually involves the flow control of the dispersed phase fluid and the continuous phase fluid in different microchannels, and the shearing process of the two phase fluids at the intersection of th...

Examples

Embodiment 1

[0038] In this example, a rotary microfluidic device that can controlly prepare monodisperse emulsion is provided, and its structural schematic diagram is as follows figure 1 As shown, a rotating platform 1 , a syringe 2 , a collection container 3 and a syringe pump 4 are included.

[0039] The rotating platform 1 includes a motor and a horizontally arranged turntable, the turntable is circular, and the motor drives the turntable to rotate at a constant speed around the center of the turntable; the cross section of the collection container 3 is circular, specifically a glass petri dish with a diameter of 20 cm, and the collection container is fixed horizontally On the turntable, that is, the circular bottom surface of the petri dish is fixed horizontally on the turntable, and the center of the petri dish coincides with the center of the turntable; the motor drives the turntable to rotate at a constant speed, and then drives the collection container on the turntable and the cont...

Embodiment 2

[0042] In this embodiment, a rotary microfluidic device for controllable preparation of monodisperse emulsion is provided, including a rotary platform 1 , a syringe 2 , a collection container 3 , a syringe pump 4 and a fluid distribution plate 6 .

[0043] The rotating platform 1 includes a motor and a horizontally arranged turntable, the turntable is circular, and the motor drives the turntable to rotate at a constant speed around the center of the turntable; the cross section of the collection container 3 is circular, specifically a glass petri dish with a diameter of 20 cm, and the collection container is fixed horizontally On the turntable, that is, the circular bottom surface of the petri dish is fixed horizontally on the turntable, and the center of the petri dish coincides with the center of the turntable; the motor drives the turntable to rotate at a constant speed, and then drives the collection container on the turntable and the continuous phase fluid in the collection...

Embodiment 3

[0047] In this embodiment, the preparation process of monodisperse water-in-oil (W / O) emulsion is taken as an example to illustrate the controllable preparation method of monodisperse emulsion provided by the present invention. The steps are as follows:

[0048] (1) Preparation of dispersed phase and continuous phase fluid

[0049] Deionized water was used as the dispersed phase fluid; T154 was dissolved in soybean oil to obtain the continuous phase fluid, and the concentration of T154 in the continuous phase fluid was 0.04g / mL.

[0050] (2) Preparation of monodisperse W / O emulsion

[0051] The rotary microfluidic device described in Example 1 is used for preparation, the continuous phase fluid is contained in a petri dish, the outlet of the injection tube is controlled to be located below the liquid level of the continuous phase fluid contained in the petri dish, and the outlet of the injection tube is in contact with the petri dish The distance between the centers of the ci...

Images