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Application of horse angelica liquid and gemcitabine in preparation of medicine for treating cancer

A gemcitabine, cancer technology, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as difficulty in administration routes, and achieve the effects of alleviating pain, reducing bladder irritation, and reducing serum VEGF levels

Active Publication Date: 2022-05-10
THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

3. The difficulty of the route of administration: After the prescription is determined, which route of administration can achieve the best curative effect, and we need further research
3. Using traditional Chinese medicine decoction bladder infusion treatment, before this has not seen traditional Chinese medicine and its compound bladder infusion for the postoperative treatment of bladder cancer

Method used

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  • Application of horse angelica liquid and gemcitabine in preparation of medicine for treating cancer
  • Application of horse angelica liquid and gemcitabine in preparation of medicine for treating cancer
  • Application of horse angelica liquid and gemcitabine in preparation of medicine for treating cancer

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preparation example Construction

[0045] like figure 1 As shown, the preparation method of Maguili liquid provided by the embodiments of the present invention comprises:

[0046] S101, cold immersing Angelica sinensis for 0.5h to extract volatile oil by steam distillation to obtain Angelica sinensis volatile oil, distilled aqueous solution and medicinal residues;

[0047] S102, decocting the obtained medicinal dregs with verbena, red peony root, and astragalus membranaceus for 3 times, combining the decoction, filtering, merging the filtrate and the aqueous solution, and standing for 24 hours;

[0048] S103, filter, concentrate to nearly 50mL, add an appropriate amount of preservative and angelica volatile oil, adjust the total amount to 50mL, stir well, potting, and sterilize.

[0049] The embodiment of the present invention provides decocting the obtained dregs with verbena, red peony root, and astragalus for 3 times, including:

[0050] The amount of water added for the three decoctions was 10 times, 8 ti...

Embodiment 1

[0053] 1 Materials and methods

[0054] 1.1 Inclusion and exclusion criteria

[0055] Inclusion criteria: (1) Urology color Doppler ultrasound and cystoscopy showed bladder tumor on admission, and postoperative pathological diagnosis confirmed non-muscle-invasive bladder cancer; (2) Age 18-85 years old, patients with initial bladder cancer; ( 3) No lymph node and distant metastasis; (4) Patients who have signed informed consent, voluntarily choose and cooperate with treatment.

[0056] Exclusion criteria: (1) with a history of chemotherapy drug allergy; (2) with other organic and serious diseases; (3) with unsustainable bladder perfusion; (4) with abnormal liver and kidney function; (5) with other reasons Patients who cannot complete the treatment plan.

[0057] 1.2 General Information

[0058] A total of 66 patients with non-muscle invasive bladder cancer who were hospitalized in our department from October 2018 to June 2020 and met the inclusion criteria were selected, in...

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Abstract

The invention belongs to the technical field of biological medicine, and discloses an application of a horse-angelica liquid and gemcitabine in preparation of a medicine for treating cancer, which comprises the following steps: within 24 hours after operation, the gemcitabine is administered based on a one-time administration scheme; and according to the administration scheme of repeating once every week for 8 weeks and repeating once every month for 44 weeks in sequence, the horse-angelica-sinensis liquid is administered. According to the present invention, after NMIBC operation, the horse angelica liquid and gemcitabine bladder perfusion treatment is performed, such that bladder irritation, hematuria and other adverse reactions can be reduced, the serum VEGF level can be effectively reduced, and NMIBC postoperative recurrence can be reduced. According to the invention, the NMBIC is treated through bladder perfusion by adopting the combination of the horse-angelica-sinensis liquid and the gemcitabine, the adverse reaction, the recurrence rate and the influence on serum vascular endothelial growth factors of a patient are observed, and the result shows that the combination of the horse-angelica-sinensis liquid and the gemcitabine is superior to the gemcitabine in the aspects of preventing bladder tumor recurrence and reducing the perfusion adverse reaction rate.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of Maguiye combined with gemcitabine in the preparation of medicines for treating cancer. Background technique [0002] Currently, bladder cancer (Bladder cancer, BC) is one of the most common malignant tumors of the genitourinary system. Chinese tumor statistics show that bladder cancer has become the seventh most common malignant tumor. Its morbidity and mortality are increasing year by year. About 70% of newly diagnosed bladder cancers are non-muscular invasive bladder cancer (NMBIC), and the postoperative recurrence rate of primary patients is still as high as 50-70%, and some recurrent tumors have increased malignancy and developed into invasive carcinoma or metastatic carcinoma. [0003] Bladder cancer is the malignant tumor of the urinary system with the highest morbidity and mortality in my country. The incidence rate of males is about 86,500 / 100...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K31/7068A61P35/00A61P13/10
CPCA61K36/481A61K36/85A61K36/232A61K36/236A61K31/7068A61P35/00A61P13/10A61K2300/00Y02A50/30
Inventor 蔡蔚蒋伟平贺潇刘起立毛璟弢黄丽玲狄奇谢晓杨华伟龙蠡谢海平
Owner THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)
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