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Application of mifepristone in intervention and treatment of nicotine addiction

A technology for mifepristone and nicotine, applied in the field of medicine, can solve the problems of high cost of Changpei, and achieve the effects of good druggability, low cost, and reduced intake frequency

Pending Publication Date: 2022-06-24
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, Chantix is ​​expensive. In the United States, the cost of using Chantix is ​​$1,800 for a 12-week course of treatment; $3,600 for a 24-week course of treatment
However, the clinical use of mifepristone has less side effects and is relatively cheap.

Method used

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  • Application of mifepristone in intervention and treatment of nicotine addiction
  • Application of mifepristone in intervention and treatment of nicotine addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Establishment of animal models of nicotine addiction and control groups

[0027] An animal model of nicotine addiction was established by intravenous self-administration of nicotine. Rats were selected as animal models, and a catheter directly to the heart was implanted in the jugular vein of the rat in advance, and the other end of the catheter was connected to a syringe pump filled with nicotine solution. After recovery from surgery, animals were trained in the control box for self-administration of nicotine. There were two pedals in the control box, and pressing one of the pedals would activate the nicotine injection pump, causing the intravenous injection of nicotine. The FR (FixedRatio) of the device is 5, and the TO (Time out) is 20s, that is, the rat gets an intravenous injection every 5 times of pedaling, and 20 seconds after that is the refractory period, that is, the intravenous injection after 5 pedaling times is completed. Even pressing the pedal ...

Embodiment 2

[0030] Embodiment 2 The influence of mifepristone on the frequency of self-administration of nicotine

[0031] For the rats in the nicotine self-administration group and the self-administration group that have been successfully modeled, a research experiment on the effect of mifepristone on the times of self-administration was carried out, with 6 rats in each group. The experimental method was a cross-control experiment within a group.

[0032] The first experiment was 1 hour before the start of the administration experiment, half of the experimental animals in each group (3 rats) were intraperitoneally injected with mifepristone solution, and the other half (3 rats) were intraperitoneally injected with solvent, mifepristone. Ketones were administered at a dose of 60 mg / kg. Then, the number of self-administration of rats in each hour in the self-administration experiment was recorded.

[0033] No drug intervention was given within 3 days after the first test, and the second ...

Embodiment 3

[0036] Example 3 The effect of mifepristone on the self-administration time of nicotine

[0037]For the rats in the nicotine self-administration group and the self-administration group that have been successfully modeled, a research experiment on the effect of mifepristone on the times of self-administration was carried out, with 6 rats in each group.

[0038] One hour before the start of the administration experiment, half (3 rats) of each group of test animals were intraperitoneally injected with mifepristone solution, the other half (3 rats) were intraperitoneally injected with solvent, and the administration of mifepristone The dose is 60 mg / kg. The time when the rats autonomously obtained the first and second intravenous self-administration in each hour of the self-administration experiment was then recorded. According to the time of the first administration and the second administration, the degree of craving for nicotine in nicotine-addicted rats can be judged, and the...

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Abstract

The invention discloses application of mifepristone in intervention and treatment of nicotine addiction. Specifically, the invention discloses an application of mifepristone in preparation of drugs for reducing nicotine addiction, dependence degree or rewarding, an application of mifepristone in preparation of drugs for relieving nicotine withdrawal symptoms and an application of mifepristone in preparation of drugs for reducing the use amount of nicotine-containing tobacco. The invention further discloses a tobacco product, and the tobacco product contains the mifepristone. It is proved for the first time that mifepristone has the effects of reducing nicotine addiction, dependence degree or reward, relieving nicotine withdrawal symptoms and reducing active intake and intake frequency of nicotine. The mifepristone is a medicine which has been marketed for many years, is good in druggability, small in toxic and side effects and very low in cost, and is expected to be developed into a nicotine abstinence medicine or an auxiliary medicine.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the use of mifepristone for intervening and treating nicotine addiction. Background technique [0002] Nicotine is the main addictive substance in tobacco, and there is a serious lack of effective drugs to treat nicotine addiction in clinic. There are three kinds of smoking cessation therapy commonly used in the world. The first is nicotine replacement therapy, which consists of nicotine sugar and patches. Mainly through the slow release of nicotine to maintain the level of nicotine in the human body and reduce the craving for tobacco when quitting smoking. The second is to take varenicline (varenicline, trade name Chantix). This is a partial agonist of the nicotine acetylcholine receptor α4β2. α4β2 receptors are abundantly expressed in the dopaminergic nervous system and play an important role in the reward of nicotine. The third is to take bupropion (bupropion, trade name Zyban), w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/567A61P25/34A24B15/18
CPCA61K31/567A61P25/34A24B15/18
Inventor 陈祖昕刘欣安
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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