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Preparation process and test method of mangosteen shell water decoction for inhibiting gastrointestinal motility

A technology of mangosteen husk and gastrointestinal motility, applied in the field of pharmacy, can solve the problems of no animal experiment confirmation and mechanism research, and achieve the effect of convenient material collection and abundant resources

Pending Publication Date: 2022-07-29
广西卫生职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a decoction preparation process and testing method for mangosteen husks to inhibit gastrointestinal motility, so as to solve the problem that the antidiarrheal effect of mangosteen husks proposed in the above-mentioned background technology is limited to folk use, and there is no relevant animal experiment confirmed that the study of the mechanism is not the problem

Method used

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  • Preparation process and test method of mangosteen shell water decoction for inhibiting gastrointestinal motility
  • Preparation process and test method of mangosteen shell water decoction for inhibiting gastrointestinal motility
  • Preparation process and test method of mangosteen shell water decoction for inhibiting gastrointestinal motility

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Embodiment 1

[0050] The invention takes mangosteen husk as the research object, and through animal experiments to explore how the mangosteen husk water decoction inhibits gastrointestinal motility and exerts an antidiarrheal effect, and provides scientific theoretical and experimental basis for developing the medicinal value of mangosteen husk , see figure 1 , The present invention provides a technical scheme: a preparation process and a test scheme of a decoction of mangosteen husks for inhibiting gastrointestinal motility.

[0051] Experimental program:

[0052] 1. Preparation of mangosteen husk decoction, charcoal powder suspension and nutritional semi-solid paste

[0053] 1. Preparation of mangosteen husk decoction

[0054] The preparation process of the water decoction comprises the following steps: peeling off the fruit of mangosteen and leaving the shell, washing the mangosteen shell and drying it in the air, and then peeling off the purple thin outer layer. The obtained mangoste...

Embodiment 2

[0071] The present invention has determined the optimal dosage of the mangosteen husk decoction, and obtained through experiments that the mangosteen husk decoction has an obvious inhibitory effect on the small intestine propulsion rate of mice. The experimental content and results are as follows:

[0072] 1. Effects of different doses of mangosteen decoction on gastric emptying speed in mice

[0073] Fifty mice were taken and randomly divided into 5 groups, 10 mice in each group, and were given low-dose, medium-dose and high-dose of mangosteen decoction respectively by intragastric administration, the positive group was intragastrically administered with atropine sulfate solution, and the blank group was intragastrically administered with the same dose of distilled water. After 0.5h, the mice were given nutritive semi-solid paste by gavage. After 1 h, the mice were killed by dislocating the cervical vertebrae, the abdomen was opened, the gastric cardia and pylorus were liga...

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Abstract

The invention discloses a preparation process and a test method of a mangosteen shell water decoction for inhibiting gastrointestinal motility, comprising a preparation process of a mangosteen shell water decoction, a charcoal powder suspension and nutritional semisolid paste, and a test method of the influence of the applied mangosteen shell water decoction on cholinergic nerves and adrenergic nerves. The mangosteen shells are utilized, the problem that how the mangosteen shell water decoction plays an antidiarrheal role can be solved through discussion of the mangosteen shell water decoction on inhibiting the gastrointestinal motility mechanism, a reference basis is provided for developing a clinically safe and effective antidiarrheal, and due to the fact that the materials are convenient to take and rich in resource, the mangosteen shell water decoction has a very good application prospect. Meanwhile, the implementation of the invention is also beneficial to deep development and utilization of local characteristic Chinese herbal medicine resources.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation process of a decoction of mangosteen husks for inhibiting gastrointestinal motility and a testing method thereof. Background technique [0002] Mangosteen, also known as mangosteen, mangosteen, mangosteen, and phoenix fruit, is native to Malaysia and is now cultivated in Guangxi, Hainan, Fujian, Taiwan and other provinces of my country. In recent years, with the increase in the number of people eating mangosteen, the number of discarded husks has also increased significantly, which has brought great convenience to experimental research, and how to effectively use these discarded agricultural products, so that the resources can be recycled and turned into treasures. . [0003] In the prior art, in Southeast Asian countries and regions, mangosteen husks can be used for the treatment of diseases such as abdominal pain, diarrhea, dysentery, cholera, infectious wounds,...

Claims

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Application Information

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IPC IPC(8): A61K36/38A61P1/12
CPCA61K36/38A61P1/12A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 林启权凌莉莉李莹庄舒婷
Owner 广西卫生职业技术学院
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