Oral liquor composition with reduced bitter taste

Abstract

The present invention relates to a bitterness-abated oral preparation composition formed by adding aminoalkyl methyl acrylate copolymer and / or glutamic acid compound in egg propadiene sodium. Said aminoalkyl methyl acrylate copolymer, optimum, is aminoalkyl methyl acrylate copolymer E and / or aminoalkyl methyl acrylate copolymer RS, and the glutamic acid compound optimally uses at least one of L-glutamine, L-sodium glutamate and L-potassium glutamate. It can greatly abate bitterness, and can be obtain egg propadient sodium oral preparation composition with good taking sense.

Description

technical field [0001] The invention relates to an oral preparation composition containing egg allenesodium (egg allenesodium) which is formulated with a bitterness-relieving agent. Background technique [0002] Ethyl allene sodium [chemical name: 3-ethyl-7-isopropyl-1-azulene sulfonate sodium 1 / 3 hydrate], after oral administration, has an excellent role in protecting the gastric mucosa, and is used as a treatment for gastric ulcers, etc. It is an excellent medicine for medicine, and it is also a medicine with a bitter taste. In the masking of the taste of pharmaceutical preparations containing such peculiar-tasting drugs, film coating is very effective for tablets, but for granules, fine granules, and powders, due to their large surface area, in order to use film coating Coating completely masks the bitter taste and requires a very thick film coating, so the disadvantage is that the dissolution in the digestive tract is very poor. [0003] As a method of reducing bittern...

AI Technical Summary

Problems solved by technology

However, in the case of sodium prothylenediene, it is difficult to sufficiently reduce its bitterness only by using such a method