The present invention relates to the field of food processing. Total-nutrient meal replacement powder containing secoisolariciresinol diglucoside comprises the following raw materials in parts by weight: secoisolariciresinol diglucoside, oat, quinoa, buckwheat, barley, black rice, millet, red beans, white kidney beans, chickpeas, mung beans, konjac gum, resistant dextrin, soy protein powder, soy peptides, wolfberry powder, flaxseed microcapsule powder, medium chain fatty acid powder, erythritol, stevioside, silicon dioxide, Vitamin A, Vitamin E, Vitamin B1, Vitamin B2, Vitamin B6, folic Acid,Vitamin C, niacin, pantothenic acid, calcium ascorbate, zinc gluconate, iron pyrophosphate and magnesium gluconate. The prepared total-nutrient meal replacement powder containing the secoisolariciresinol diglucoside has the effects of anti-tumor and increasing satiety.