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Adsorbent capable of reducing in vivo urotoxin

A technology for adsorbents and urea toxins, applied in the direction of anti-drugs, urinary system diseases, carbon active ingredients, etc., can solve the problems of interfering with the normal function of the gastrointestinal tract, limited effect, poor adsorption of urea toxin precursors, etc., and achieve high adsorption force, reduce the incidence, reduce the effect of accumulation

Inactive Publication Date: 2015-06-03
JINGYUN BIOLOGICAL TECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previous urea toxin-reducing adsorbents have poor adsorption capacity for urea toxin precursors and have no selective adsorption function
Therefore, the previous adsorbents have limited effect in slowing down the decline of renal function, and cannot avoid interfering with the normal function of the gastrointestinal tract

Method used

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  • Adsorbent capable of reducing in vivo urotoxin
  • Adsorbent capable of reducing in vivo urotoxin
  • Adsorbent capable of reducing in vivo urotoxin

Examples

Experimental program
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Effect test

Embodiment 1

[0039] This embodiment provides an adsorbent that can reduce urea toxins in the body. The adsorbent is a polyacrylonitrile activated carbon fiber coated with a capsule, and the polyacrylonitrile activated carbon fiber is made of polyacrylonitrile carbon fiber cloth ( 30, Zoltek Companies, Inc.) were oxidized and then ground in aqueous carbon dioxide gas at 1000°C for 5 minutes and then ground. The polyacrylonitrile carbon fiber cloth is composed of 90wt% polyacrylonitrile plus 10wt% rayon (Rayon) or pitch (petroleum pitch). The activated carbon fiber has an average diameter of 7.6 μm and a BET specific surface area of ​​964 m 2 / g, the density is 2.13g / m 3 , The percentage of micropores / mesopores / macropores is 22 / 78 / 0%, the length is 23.2±6.9μm, the total acidic groups are 1.092meq / g, and the total basic groups are 1.30meq / g. figure 1 This is the appearance of the activated carbon fiber of this example.

[0040] figure 2According to the in vitro adsorption test results, ...

Embodiment 2

[0050] The adsorbent of the present embodiment is to coat polyacrylonitrile activated carbon fiber with a capsule, and this polyacrylonitrile activated carbon fiber is made of polyacrylonitrile carbon fiber cloth ( 30, Zoltek Companies, Inc.) is oxidized and ground at 900°C for 20 minutes in water-containing carbon dioxide gas, and then ground. Its properties are as follows: the average diameter is 9.3 μm, and the BET specific surface area is 398m 2 / g, the density is 1.749g / m 3 , The percentage of micropores / mesopores / macropores is 18 / 82 / 0%, the length is 27.1±2.4μm, the total acidic groups are 1.559meq / g, and the total basic groups are 0.9meq / g. The results of in vitro adsorption tests were as follows: figure 2 As shown, this Example 2 can adsorb 75.3% of indole and 6.3% of lipolytic enzymes, indicating that this Example 2 has a higher adsorption capacity for uremic toxin precursors and a lower adsorption for intestinal enzymes force.

Embodiment 3

[0052] The adsorbent of the present embodiment is to coat polyacrylonitrile activated carbon fiber with a capsule, and this polyacrylonitrile activated carbon fiber is made of polyacrylonitrile carbon fiber cloth ( 30, Zoltek Companies, Inc.) is oxidized and ground at 900°C for 40 minutes in aqueous carbon dioxide gas, and then ground. Its properties are as follows: the average diameter is 8.6 μm, and the BET specific surface area is 921m 2 / g, the density is 2.043g / m 3 , The percentage of micropores / mesopores / macropores is 21 / 79 / 0%, the length is 21.9±1.4μm, the total acidic groups are 1.384meq / g, and the total basic groups are 1.26meq / g. The results of in vitro adsorption tests were as follows: figure 2 As shown, this Example 3 can adsorb 84.7% of indole and 4.4% of lipolytic enzymes, indicating that this Example 3 has a higher adsorption capacity for uremic toxin precursors and a lower adsorption for intestinal enzymes force.

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Abstract

The invention discloses an adsorbent capable of reducing in vivo urotoxin. The adsorbent comprises a polyacrylonitrile active carbon fiber with the characteristics that (1) the mean diameter is 5-30 microns; (2) the BET specific surface area is greater than 390m<2> / g; and (3) the total acidic group is greater than 1.2meq / g or the total basic group is greater than 1meq / g. The adsorbent has relatively high adsorption capacity on an urotoxin precursor, but has relatively low adsorption capacity on normal ferment in intestinal tracts. Therefore, the urotoxin adsorbent disclosed by the invention is capable of effectively relieving deterioration of the renal function, and is used as a therapeutic agent or a preventive for kidney diseases.

Description

technical field [0001] The present invention relates to an oral substance for treating or preventing kidney diseases, in particular to an adsorbent capable of reducing uremic toxins in the body, which is used for reducing uremic toxins in individuals and slowing down the deterioration of renal function. Background technique [0002] The metabolic wastes excreted by the kidneys are commonly called urea toxins, and the concentration of urea toxins in serum can be used as an indicator of renal function. A uremic toxin: indoxyl sulfate (indoxyl sulfate) is considered to be one of the main causes of exacerbation of chronic kidney disease. The production process of indoxyl sulfate is that the bacteria in the intestine metabolize the tryptophan (Tryptophan) ingested from food into indole (Indole), and indole is metabolized into indoxyl sulfate in the liver, and then excreted through the kidneys. When renal function declines, indoxyl sulfate and other urea toxins, such as creatinin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61P39/00A61P13/12
Inventor 柯泽豪林瑞祥徐唯珊鐘婉予
Owner JINGYUN BIOLOGICAL TECH SHANGHAI
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