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Light-stabilized in vivo stain composition and method of manufacture

A dye and molecular technology, applied in the field of thiazine dye biological dyeing composition, can solve the problems of uncertain initial composition, changes, and abnormal clinical observation

Inactive Publication Date: 2006-08-16
ZILA BIOTECHNOLOGY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of this substance, which is generally called "TC" in the prior art, has led to the failure of normal clinical observation, and there are also serious problems in the necessary regulation of the manufacture and sale of this product for human diagnosis
[0003] In addition to the problem of uncertain initial composition, the composition of existing TC and other thiazide biostains can change over time

Method used

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  • Light-stabilized in vivo stain composition and method of manufacture
  • Light-stabilized in vivo stain composition and method of manufacture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] This example illustrates the photostability of TC products containing very small amounts of metal ions.

[0017] A sample of the TC product was prepared according to Example 1 of the applicant's US Pat. No. 6,086,852, which is hereby incorporated by reference, and then further purified by preparative high performance liquid chromatography. The total metal content of the sample was less than 0.2 wt%.

[0018] A small sample of this purified TC product is dark blue. After standing overnight in the test chamber, the solution became colorless when exposed to an incandescent lamp environment.

Embodiment 2

[0020] The sample in Example 1 was used, except that the solution contained approximately 4% by weight of zinc (as zinc chloride) and 9% sodium (as sodium chloride) in an incandescent lamp environment. is actually absolutely stable.

Embodiment 3

[0022] Similar results were obtained by repeating the procedures of Examples 1 and 2 with methylene blue, cerulean A and cerulean C in place of TC.

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Abstract

Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state.

Description

technical field [0001] The present invention relates to photostable thiazine dye biological dye compositions, such as the toluidine blue chloride ("TC") dye compositions disclosed in the applicant's US Patent No. 6,086,852. On the other hand, the present invention also relates to the preparation of these compositions. In particular, the present invention relates to photostable chlorinated toluidine blue ("TC") dye compositions and methods for their preparation. Background technique [0002] It has been reported that past workers such as Mashberg (US Pat. No. 4,321,251) proposed the use of TC for the identification of abnormal structures in vivo, and he used a dye product in the prior art in which the conformational isomer of TC is associated with the The sum of the N-demethylated and N,N-demethylated derivatives of the conformers is less than 80%, and in this dye product, these two N-demethylated conformers are Alkylated derivatives exceeded about 20% of the dye compositio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00C07D279/18A61K47/02C09B21/00C09B67/00
CPCA61K47/02A61K49/006A61K49/00
Inventor 道格拉斯·D·伯克特
Owner ZILA BIOTECHNOLOGY INC