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Use of 17-'alpha'-estradiol for treatment of aged or sundamaged skin and./or skin atrophy

A technology of α-estradiol and skin, which is applied in the fields of sun damage skin, skin atrophy and wound healing, treatment of aging skin, and acne, and can solve problems such as weak estrogen activity and insignificant biological response

Inactive Publication Date: 2000-12-13
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our studies demonstrate that topical 17-α-estradiol is as effective as 17-β-estradiol in inducing the synthesis of new connective tissue molecules in the dermis of mouse skin, whereas it is less active as a systemically administered estrogen , so 17-alpha-estradiol after topical application would be expected to have insignificant biological responses in non-cutaneous tissues such as the genital tract if it is absorbed into the bloodstream
Use of 17-alpha-estradiol has been reported to be associated with alopecia, hair loss, or hair growth, and there are no data showing its effectiveness in the management of other skin conditions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0028] deal with

[0029] The results show a compound dose dependent response and an effect of treatment time. After 6 or 10 weeks of treatment, 17-α-estradiol was equivalent to 17-β-estradiol and all-trans retinoic acid in its effect on connective tissue repair.

Embodiment 3

[0031] deal with

[0032] The table above shows the dose-dependent responses of 17-alpha-estradiol and 17-beta-estradiol. 17-β-estradiol was stronger, and 17-α-estradiol also showed the same therapeutic effect.

Embodiment 4

[0034] deal with

[0035] The above table demonstrates that 17-α-estradiol is equally effective as 17-β-estradiol in skin thickening effect due to water retention mediated by increased amount of hyaluronic acid.

[0036] deal with

[0037] These results suggest that 17-α-estradiol and 17-β-estradiol act like the retinoid all-trans retinoic acid by increasing the thickness of the epidermis. Thus, 17-alpha-estradiol is beneficial for skin conditions of epidermal atrophy resulting from intrinsic aging of the skin or pathological conditions resulting from overexposure to the sun, injuries, etc. Promoting epidermal proliferation may also be of value in conditions like acne. In this case, stimulation of the follicular epithelium may have an anti-comedogenic effect, helping to expel hyperkeratotic material.

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PUM

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Abstract

The present invention relates to a method for treatment of mammalian skin conditions where stimulated connective tissue synthesis is beneficial, comprising treating skin in need of such treatment with a safe and effective amount of 17-alpha-estradiol.

Description

[0001] This application is Serial No. (TBD) of Patent Application entitled 17-alpha-Estradiol Use in the Treatment of Aging or Sun Damaged Skin and / or Skin Atrophy (Attorney No. JBP-431) filed Tuesday, August 4, 1998 Continuation-in-Part of the above application, the entire subject matter disclosed in the above application is hereby incorporated by reference. This application also claims priority to Provisional Application No. 60 / 056,485, filed August 21,1997. field of invention [0002] The present invention relates to methods of treating mammalian skin conditions by stimulating the synthesis of connective tissue where the synthesis of connective tissue is favorable. In particular, the present invention relates to novel compositions and methods of treating aging skin, sun damaged skin, acne, skin atrophy and wound healing using the same. background of the invention [0003] Estrogens are hormonal compounds that exhibit a broad spectrum of biological effects on target tissu...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K8/63A61K31/565A61P17/00A61Q19/00A61Q19/08
CPCA61Q19/00A61K8/63A61K31/567A61Q19/08A61P17/00
Inventor G·J·让德梅克J·A·梅齐克
Owner JOHNSON & JOHNSON CONSUMER COPANIES
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