Application of fullerol of C60 derivative in nourishing hair

A technology of fullerenol and hydroxy derivatives, applied in the direction of drug combination, carbon active ingredients, skin diseases, etc., can solve problems such as unrevealed hair status, and achieve good hair growth effect

Inactive Publication Date: 2007-01-24
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] found by Yamago et al. 14 C-labeled water-soluble C 60 After intravenous injection of the carboxylic acid derivatives of the mice, the fur of the mice has considerable uptake, but it has not been revealed whether the high uptake rate of the above-mentioned fullerene derivatives in the fur can improve the hair condition of living animals, namely C 60 There is no relevant report on the application of and its derivatives in improving hair preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1C 60 A simple water-soluble derivative of fullerenol C 60 (OH) x (x=14-16) Preparation

[0015] 500mg C 60 Dissolve in 10ml of toluene, add to reaction bottle B, deoxygenate with nitrogen for 5 minutes. Add 10g of sodium nitrite to reaction bottle A, add concentrated nitric acid dropwise, and the gas produced is passed into reaction bottle B. After 15 minutes, after 2 hours of reaction, stop the reaction, evaporate the solvent under reduced pressure to obtain black nitro C 60 compound, was added to 25ml of 3N sodium hydroxide solution to obtain a suspension, and heated at 40°C for 4 hours. Add 80ml of methanol to get a black precipitate, centrifuge to separate the precipitate, wash 3 times with methanol, and dry the resulting solid in vacuo to obtain Fullerenol C 60 (OH) x (x=14-16).

Embodiment 2

[0016] Example 2C 60 A simple water-soluble derivative of fullerenol C 60 (OH) x (x=23-24) Preparation

[0017] 100mg C 60 Dissolve in 100ml refined toluene, add 4ml 4M aqueous sodium hydroxide solution, 64 drops of 10% tetrabutylammonium hydroxide, 10ml 30% H 2 o 2 , heated to reflux at 110°C, and added 10ml of 30% H after 25 minutes 2 o 2 After 2 hours, the toluene layer changed from purple to colorless, and the water layer was light yellow. Stop heating, separate the water layer, and precipitate it with methanol. After dissolving the solid in water, heat it at 80°C for hydrolysis, and dry at 100°C to obtain fullerenol C 60 (OH) x (x=23-24).

Embodiment 3

[0018] Example 3C 60 A simple water-soluble derivative of fullerenol C 60 (OH) x (x=30) Preparation

[0019] 20mg C 60 Dissolve in 20ml of toluene solution, add 10ml (1g / ml) of KOH solution, 3 drops of tetrabutylammonium hydroxide, stir for 12 hours, separate the water layer, precipitate with methanol to obtain a brown solid, wash with methanol for 3 times, and dry the obtained solid in vacuum Fullerenol C 60 (OH) x (x=30).

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PUM

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Abstract

An application of the fullerol as the delivative of C60 in preparing the medicines for nourishing, protecting and growing hair and preventing alopecia is disclosed.

Description

technical field [0001] What the present invention relates to is C 60 Application of derivatives of fullerenol in the preparation of hair nourishing preparations. Background technique [0002] The third allotrope of carbon C 60 And its family-fullerene was discovered in 1985, and the three chemists who discovered fullerene shared the 1996 Nobel Prize in Chemistry. Typical member C in fullerene 60 It is a spherical molecule with a special hollow cage structure composed of 60 carbon atoms, including 12 five-membered rings and 20 six-membered rings, and its diameter is 0.71nm. The special structure endows them with many strange physical and chemical properties. In 1990, gram-level C could be prepared by arc discharge method. 60 After the method, the research and application of fullerenes in physics, chemistry and materials science has developed rapidly, and has become a remarkable research hotspot in the world. Although the research on the biological activity and applicati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/44A61P17/14
Inventor 刘瑞丽蔡小青李文新
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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