43results about How to "Unique biological activity" patented technology

The invention discloses a catalytic carbonylation method for synthesis of alpha-keto amide. A palladium source in an aqueous solution of polyethylene glycol or polyethylene glycol is used for in-situ formation of a highly active palladium nano-catalyst; and the palladium nano-catalyst can efficiently catalyze bis-carbonylation reaction of aryl halide and aliphatic amine for one-step synthesis of an alpha-keto amide compound by using carbon monoxide as a dicarbonyl source in the presence of alkali or without alkali, and does not require ligand. The synthesis method of alpha-keto amide uses the palladium nano-catalyst formed in situ, the reaction does not require ligand promotion and can achieve conversion with high efficiency and high selectivity; the substrate is stable, cheap and readily available, has good universality of functional groups; and the operation is safe and simple.

The present invention relates to a preparation method of a novel dermal filler. The method adopts low-toxic amino acid and its derivatives as cross-linking agent to prepare cross-linked sodium hyaluronate gel; Mild and easy to handle and other advantages, the basic amino acids-lysine and arginine or their derivatives among the essential amino acids for the human body are selected as the cross-linking agent to undergo a cross-linking reaction with the carboxyl end of the sodium hyaluronate molecule, and then partially seal the body The recognition site of hyaluronidase delays the recognition and degradation of the enzyme, and finally increases the residual time in the body. It provides a new technology for the development of safe and long-acting sodium hyaluronate injectable cosmetic fillers. Better market development prospects.

The invention relates to a quinoa peptide. The quinoa peptide is prepared by the following preparation steps: (1) Extraction of buckwheat protein: Wash buckwheat grain, dry, add petroleum ether and grind evenly, after standing soaking, dry petroleum ether, grind into fine Powder, and then hydrolyzed with [alpha]-amylase to obtain buckwheat protein; (2) hydrolysis of buckwheat protein: the buckwheat protein obtained after step (1) is added, and is composed of flavor protease and alkaline protease. The double enzyme preparation is subjected to double enzyme hydrolysis. In addition to its characteristics of digestibility, easy absorption and low antigen, the buckwheat peptide also has unique biological activities such as anti-oxidation, blood pressure lowering and blood sugar lowering, whichopens up a new way for the high value-added transformation of buckwheat. It also provides a theoretical basis for the deep development and utilization of multi-functional nutritious food.

The invention provides a 3-(substituted bisulfonyl fluromethane)-1-propylene compound, a synthetic method and applications thereof. The method is an effective method for synthesizing the optically active 3-(substituted bisulfonyl fluromethane)-1-propylene compound with iridium complex as catalyst and allyl carbonic ester and diphenylsulfonyl fluomethane compound in a highly regional and highly enantioselective manner. The catalyst is easy to obtain and has high activity; the reaction conditions are mild; a substrate has a wide application range and the products have high regional and enantioselectivity. The synthesized 3-(substituted bisulfonyl fluromethane)-1-propylene compound is easy for preparing fluorochemicals which contain aldehyde, alcohol, amine, carboxylic acid or poly-cycle, arewidely applied to pesticides and drugs and have special physiological activities in a chemical way.

The invention disclosed a kind of spirulina which contains spirulina active peptide, protease and kinas, the preparing method and application is also included in the invention. The spirulina contains all round nutrients and has the function of regulating the body blood fat, but the function is very mild and slow. Besides, there are no reports about the molecular spirulina active peptide, protease and kinas existing in spirulina. The invention has fermented the spirulina with Bacillus subtitles to get spirulina that contains spirulina active peptide, protease and kinas. The detecting results show that the spirulina contains 15-40% (W/W) active peptide, 100-10000U/g protease and 1000-80000FU/g kinas when the water content of the spirulina is lower than 7%. The clinical examination shows that the invention has the function of dissolving thrombus, preventing high viscosity blood disease, and hypertensive disease.

The invention discloses a small-molecule fluorescent probe taking 3-hydroxyflavone as a fluorophore and application of the small-molecule fluorescent probe. An excited state intramolecular proton transfer (ESIPT) strategy system is adopted in a DMSO/H2O (5: 1, v/v) solution, high-selectivity response to group IIIA metal ions is shown relative to other cations, green fluorescence is converted intoblue fluorescence, ultraviolet absorption peaks are subjected to red shift, and along with the increase of the concentrations of Ga, Al and In ions, the metal ions are strongly combined with the probe, so that the Ga, Al and In ions are accurately detected by a fluorescence technology, and endogenous and exogenous Ga, Al and In ions in living cells can be detected. Therefore, the method has a goodapplication prospect in the aspect of Ga, Al and In ion detection, and meanwhile, the synthesis method disclosed by the invention is simple and convenient to operate, and does not need harsh conditions.

The invention discloses a protein nutritious product as well as a preparation method and application thereof. The protein nutritious product is a gene peptide product with nanometer grain size which is directly obtained by carrying out enzyme hydrolysis, enzyme inactivation, separation, concentration freeze-drying or spray drying on three edible bacteria raw materials comprising agaricus blazei bacterial powder, cordyceps bacterial powder and grifola frondosa bacterial powder, is rich in active ingredients such as polysaccharide and the like, is easier to absorb, has no toxic and side effects, can take effect in dose of milligram, has higher officinal value and edible value and can be used as multiple traditional Chinese medicines, health care food, single raw material preparation of functional food and other foods as well as additive of health care products.

The invention discloses a preserving fluid of a collagen mask. According to a formula of the preserving fluid of the collagen mask, each 100 mL of distilled water contains the following ingredients: 0.10-10.00 g of a bonded compound of hyaluronic acid and antibacterial peptide, 0.05-0.4 g of a skin-whitening agent, 0.05-0.4 g of a cutin softener, 0.05-0.4 g of a skin anti-wrinkling agent, 0.2-1.2 g of a skin repairing agent and 0.2-2 g of aromatic. The collagen mask of the invention can be used along with existing collagen masks in the market and also can be marketed alone; the bonded compound of hyaluronic acid and antibacterial peptide in the formula is a non-irritating broad-spectrum antibacterial disinfector, is safe and nonirritating, and has high stability; and the collagen mask obtained after being immersed in the preserving fluid will not produce irritating feelings such as stabbing pain and the like on face and has a moisturizing function and can perform a beauty treatment effect to the greatest extent.

The invention discloses a sea cucumber culturing feed additive and a preparing and using method thereof. The feed additive is prepared from medical stone and Chinese herbal medicaments, wherein the mass mixing ratio of the medical stone to the Chinese herbal medicaments is 50-70:50-30; and the Chinese herbal medicaments comprise 30 to 50 mass percent of raidx astragali, 15 to 25 mass percent of Chinese angelica, 5 to 15 mass percent of common andrographis herb, 5 to 15 mass percent of honeysuckle flower, 5 to 15 mass percent of indigowoad leaf and 5 to 15 mass percent of fried scorch-fried crataegus. The preparation method comprises: grinding the components respectively; sieving the ground components with a 60 to 100 mesh sieve; and feeding the ground components in ratio into a feed mixer to stir the components uniformly, wherein the required coefficient of variation (CV) of mixing precision is less than 10 percent. The ratio of the sea cucumber culturing feed additive to the feed is 1:9, the feed additive is added into the feed, and the mixture is mixed uniformly and used in a larva pool. The sea cucumber culturing feed additive has the advantages of avoiding secondary pollution, reducing water exchange, effectively promoting the growth of sea cucumbers, improving the body immunity and disease resistance of the sea cucumbers, reducing the use of antibiotics and chemical medicaments, along with widely available raw materials, safety, no toxicity and convenient use.

The invention discloses a method for carbonylation synthesis of diaryl ketones through iron catalysis and belongs to the technical field of catalytic synthesis. According to the method, in a solvent alcohol or alcohol aqueous solution, and in the action of alkali, acid and iodide, an iron catalyst is added for catalyzing a direct cross-coupling reaction of an aryl halogenated compound, an aryl boron compound and a carbonyl source including haloform or carbon tetrahalide to prepare a diaryl ketone compound. The method for preparing a diaryl ketone compound through a coupling reaction is safe in carbonyl source and easy to treat and is cheap; the catalyst is available in sources and low in toxicity and is cheap; the reaction is free of ligand and good in activity; the reaction condition is mild and the selectivity is high; the substrates are available in sources and are stable; the functional groups of the substrates are good in compatibility and the substrates are wide in application range; and the reaction medium is green and can be reused. In an optimized reaction condition, the separation yield of a target product can reach 94%.

The invention discloses a high-strength slow release compound fertilizer for olive. The high-strength slow release compound fertilizer is prepared from the following components including a first component, a second component and a third component, wherein the weight ratio of the first component to the second component to the third component is (20-30) to (50-60) to (35-45); the first component is prepared from the following components in parts by weight: 30-45 parts of plant ash, 20-30 parts of animal manure, 4-6 parts of a chelated ferric fertilizer, 15-23 parts of calcium superphosphate, 10-18 parts of sulfate, 1-3 parts of sodium molybdate and 5-6 parts of boric acid; the second component is prepared from the following components in parts by weight: 95-120 parts of a slow release compound fertilizer, 10-15 parts of lignite, 8-13 parts of powdered rock phosphate, 8-13 parts of bentonite and 5-10 parts of kaolin; the third component is prepared from the following components in parts by weight: 20-30 parts of ammonium nitrate, 15-22 parts of potassium chloride and 15-20 parts of a calcium magnesium phosphate fertilizer. The high-strength slow release compound fertilizer accords with the absorption regularity of the olive to nutrients, is high in fertilizer utilization ratio and is capable of obviously promoting the olive to grow and increasing the yield of the olive.

The invention discloses a method for preparing differently morphological hydroxyapatite by using waste shells and belongs to the field of inorganic synthesis. The differently morphological hydroxyapatite is prepared under a constant-temperature water bath condition by using waste shells as a calcium source, using ammonium phosphate as a phosphorus source and regulating a pH value through ammonia water; in a process, the waste shells are used as raw materials, no morphology regulating agent or other surfactant is added, and the pH value is regulated in a constant-temperature water bath reaction process to achieve the purpose of preparing the differently morphological hydroxyapatite. The method for preparing the differently morphological hydroxyapatite by using the waste shells has the features of mild reaction conditions, high product purity, no impurities and stable quality, the production cost is low, no waste is discharged, the process flow is short, the synthesis time is short, the differently morphological hydroxyapatite with a higher utilization value is produced, and a new direction is opened for industrial production of morphologically controllable hydroxyapatite.

The invention discloses a method for activating lignite. The method comprises the following steps: mixing lignite powder, a photocatalytic oxidizing agent and water uniformly; and completely stirringunder the condition of ultraviolet irradiation, adding the oxidizing agent in batches, and reacting at 30 to 60 DEG C for 0.15 to 24 hours to obtain activated lignite, wherein the photocatalytic oxidizing agent is titanium dioxide. By the method provided by the invention, the water-soluble organic humus content and the active group content of the lignite can be increased very obviously and large-scale application of the lignite is further realized; and the method provided by the invention is environment-friendly, pollution-free, short in process route, low in cost, simple in requirement on equipment and mild in condition, and can be applied to industrialized mass production.

The present invention relates to a preparation method of a seasoning freshness-increasing powder. The purpose of the invention is to provide the preparation method of the natural freshness-increasingabalone powder. The preparation method comprises the following steps: adding abalone viscera into seafood juice, and conducting pulping, enzymolysis, chitosan adsorption, maillard reaction, embeddingand spray drying. The freshness-increasing abalone powder obtained by the method is strong in flavor, mellow in mouth feel and free from bitter or astringent taste, contains no freshness component such as monosodium glutamate, I+G, disodium succinate and HVP, can replace the freshness seasonings, meets the requirement of the freshness enhancement without adding monosodium glutamate to applicationfoods, and is a high-quality and low-cost seafood seasoning.

The invention provides an application of an 8-hydroxyquinoline rare earth metal organic complex to an anti-new coronavirus (SARS-CoV-2) product and a preparation method of the 8-hydroxyquinoline rareearth metal organic complex. The 8-hydroxyquinoline rare earth metal organic complex takes one of rare earth metal elements cerium, lanthanum, praseodymium and europium as a central atom and 8-hydroxyquinoline as a ligand, wherein the central atom rare earth metal has physiological and biological activity, the ligand can form a coordination bond with a chemical group of an active part of the novelcoronavirus, after rare earth metal ions and 8-hydroxyquinoline form a complex, the antiviral effect can be improved, and the complex has a very high antiviral activity rate for the novel coronavirus. The 30s anti-new coronavirus activity rate of the organic complex provided by the invention reaches 99.55%, and the 1min anti-new coronavirus activity rate reaches 99.99%. The preparation method provided by the invention has the advantages of easily available raw materials, simple operations, mild reaction conditions and high yield.

A preparation method and an application method of a green additive capable of alleviating oxidative stress of broiler chickens. The preparation method includes following steps: employing raw materials including following components, by weight, 300 parts of an extract of origanum vulgare, 50 parts of [alpha]-tocopherol acetate, 100 parts of VC phosphate and the balance 1000 parts of a carrier; and uniformly mixing the raw materials to obtain the green additive. The carrier is composed of porous adsorptive zeolite powder and corncob powder according to a weight part ratio being 2:1. The adsorptive zeolite powder and the corncob powder are subjected to pre-crushing process to enable a fineness to be 10-100 meshes. The green additive is significant in application effect during feeding, can replace, or partially replace antibiotics, and has important significances on improving a production level of the broiler chickens, ensuring product safety of the broiler chickens, maintaining ecological environment and promoting a healthy sustainable development of livestock breeding industry.

The present invention relates to a cholic acid-modified glucosamine derivative and a preparation method and application thereof, the derivative is shown as the formula (I), wherein R1 is H or OH, R2 is H or OH, and R3 is H, CH2 = CHCO-or CH2 = C (CH3) CO-. In the presence of a carbodiimide condensing agent, cholic acid is reacted with an excess amount of N-hydroxysuccinimide or 1-hydroxybenzotriazole to produce cholic acid active ester, the cholic acid active ester is then reacted with D-glucosamine to produce a derivative with no polymeric group; or the cholic acid active ester is first reacted with vinyl-containing acyl chloride, and then reacted with D-glucosamine to produce a derivative with a polymeric group; the derivative has good biocompatibility, the derivative with no polymeric group can be used as a drug for treatment of osteoarthritis, the derivative with the polymeric group can be used as a cartilage repair material organic matrix, or used for building in-situ formed glucosamine function hydrogel.

An application of the fullerol as the delivative of C60 in preparing the medicines for nourishing, protecting and growing hair and preventing alopecia is disclosed.

The invention discloses antioxidant calcium supplement cheese walnut cakes prepared by the following components by weight: 300-350 of cake flour, 100-120 of oat powder, 10-12 of ultramicro tea powder, 30-35 of fishbone paste, 10-12 of baking powder, 50-60 of sea-buckthorn peel residues, 10-12 of salt, 20-23 of butter, 23-25 of cream, 50-60 of cheese, 5-6 of yeast dry powder, 23-25 of shaddock honey, 5-6 of citric acid, 20-23 of fish skin collagen, 10-12 of peach gum, 5-6 of ginseng polysaccharide and 30-35 of taro powder. The antioxidant calcium supplement cheese walnut cakes taste crisp, and are nutritious, colored, loose, soft and chewy, and the contained beneficial components have the health care effects of oxidation resistance, calcium supplement and immunity enhancement and the like.

The invention discloses an antiviral compound containing luteolin and a preparation method thereof. The method comprises the following steps: taking luteolin and quercetin as raw materials, carrying out free radical reaction, carrying out C-O coupling reaction, firstly, carrying out reaction by utilizing N-bromosuccinimide and luteolin, taking dibenzoyl peroxide as a reaction initiator and synthesizing the 8-bromoluteolin; then, protecting quercetin, luteolin and 8-bromoluteolin through borax; and by taking cuprous chloride or cuprous iodide as a catalyst, 2,2,6,6-tetramethyl-3,5-heptanedioneor 1,10-phenanthroline as a ligand and cesium carbonate as an alkali, carrying out reacting under the protection of nitrogen, and deprotecting by using hydrochloric acid after the reaction is finishedto obtain the product antiviral luteolin-quercetin or antiviral luteolin-luteolin compound. The process is simple in production and low in cost, and industrial large-scale production of the antiviralluteolin-quercetin and the antiviral luteolin-luteolin compound is facilitated.

A Chinese medicinal composition with bactericidal and anti-inflammatory effects is prepared from the following raw materials in parts by weight: poplar bud 60-80 part, radix angelicae 8-10 parts, cassia seed 3-6 part, ginger 3-6 parts, mint 3-6 part, radix puerariae 3-6 parts. The Chinese medicinal composition provided by the invention is rich in unique biological activity and is natural, green and pollution-free substance capable of improving human immunity. It has a wide range of antibacterial and antiviral functions, and can inhibit or kill pathogenic bacteria and viruses. It has anti-inflammatory and analgesic effects on skin inflammation, oral inflammation and visceral inflammation, and has good healing and healing effects. It has the function of promoting cell regeneration, wound, burn and scald, and has good effect on wound healing.