5',8-di(dimethylbiguanide)luteolin-chromium(III) complex

A technology of dimethyl biguanide and luteolin, applied in the field of biomedicine, can solve problems such as toxicity reduction and heavy metal poisoning, and achieve the effects of low cost and simple production process

Active Publication Date: 2019-11-12
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Supplementing the body with inorganic trace elements alone will lead to heavy metal poisoning, but if the inorganic trace elements are converted into organic trace elements, the toxicity will be greatly reduced

Method used

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  • 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex
  • 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex
  • 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Preparation of 5',8-bis(dimethylbiguanidino)luteolin-chromium(III) complex:

[0033] Step a: Dissolve NBS in acetone and stir at room temperature, avoid light, dissolve as much as possible, pour into the dropping funnel for dropwise addition, dissolve luteolin in acetone, add BPO, put the dropping funnel under ice bath Start to add slowly, heat to 90°C after the dropwise addition, and react for 18 hours. After the reaction, carry out vacuum distillation to remove acetone, wash with deionized water several times, and freeze-dry to obtain bromoluteolin, wherein n(luteolin):n(NBS)=1:1.5, m(BPO):m(luteolin)=5%;

[0034] Step b: adding the bromoluteolin prepared in step a into a three-necked flask, using absolute ethanol as a solvent, sodium carbonate as a base, potassium iodide as a catalyst, adding metformin hydrochloride, and reacting at 100°C for 20 hours under stirring conditions, Obtain 5',8-bis(dimethylbiguanide base) luteolin hydrochloride, wherein n(metformin hydro...

Embodiment 2

[0039] Preparation of 5',8-bis(dimethylbiguanidino)luteolin-chromium(III) complex:

[0040] Step a: Dissolve NBS in acetone and stir at room temperature, avoid light, dissolve as much as possible, pour into the dropping funnel for dropwise addition, dissolve luteolin in acetone, add BPO, put the dropping funnel under ice bath Start to add slowly, and after the dropwise addition, heat to 70°C and react for 12 hours. After the reaction, carry out vacuum distillation to remove acetone, wash with deionized water several times and then freeze-dry to obtain bromoluteolin, wherein n(luteolin):n(NBS)=1:1.1, m(BPO):m(luteolin)=4%;

[0041] Step b: adding the bromoluteolin prepared in step a into a three-necked flask, using absolute ethanol as a solvent, sodium carbonate as a base, potassium iodide as a catalyst, adding metformin hydrochloride, and reacting at 95° C. and stirring for 18 hours, Obtain 5',8-bis(dimethylbiguanide) luteolin hydrochloride, wherein n(metformin hydrochloride)...

Embodiment 3

[0050] Preparation of 5',8-bis(dimethylbiguanidino)luteolin-chromium(III) complex:

[0051] Step a: Dissolve NBS in acetone and stir at room temperature, avoid light, dissolve as much as possible, pour into the dropping funnel for dropwise addition, dissolve luteolin in acetone, add BPO, put the dropping funnel under ice bath Start to add slowly, after the dropwise addition is completed, heat to 60°C, react for 9 hours, after the reaction, carry out vacuum distillation, evaporate acetone, wash with deionized water several times and freeze-dry to obtain bromoluteolin, wherein n(luteolin):n(NBS)=1:1.2, m(BPO):m(luteolin)=3%;

[0052] Step b: adding the bromoluteolin prepared in step a into a three-necked flask, using absolute ethanol as a solvent, sodium carbonate as a base, and potassium iodide as a catalyst, adding metformin hydrochloride, and reacting at 85° C. and stirring for 14 hours, Obtain 5',8-bis(dimethylbiguanide base) luteolin hydrochloride, wherein n(metformin hydr...

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Abstract

The invention discloses a 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex and a production method thereof. Luteolin is used as a raw material, and through a free radical reaction, a nucleophilic substitution reaction and complexation of trivalent chromium, the 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex is produced. According to the 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex and the production method thereof, structure modification is conducted on the luteolin by means of an active functional group, the production technology is simple, the cost is low, and industrial large-scale production of the 5',8-di(dimethylbiguanide)luteolin-chromium(III) complex is benefited.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a 5',8-bis(dimethylbiguanide) luteolin-chromium (III) complex and a preparation method thereof. Background technique [0002] Edible fungi are a kind of healthy food. They are rich in nutrients such as vitamins, minerals, proteins, polysaccharides and flavonoids, so they have high edible and application value, and they are low in fat and calories. Grifola frondosa ( Grifola frondosa ), also known as Polyporus bayae, is an edible fungus with a wide range of sources. Its mature fruiting bodies are dark gray-brown in flesh, and the color gradually becomes light gray afterward. Various chemical active ingredients such as flavonoids, polysaccharides, organic acids, alkaloids, coumarins, steroids and triterpenes can be isolated and purified from Grifola frondosa. These active ingredients have the functions of lowering blood fat, blood sugar, Moisturizing the lungs, pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F11/00C07D311/30A61P3/10A61P3/06A61P29/00A61P35/00A61K31/555
CPCC07D311/30C07F11/005A61P3/10A61P3/06A61P29/00A61P35/00
Inventor 刘斌葛小东童爱均陈颖李鑫
Owner FUJIAN AGRI & FORESTRY UNIV
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