Novel synergistic compositions containing aromatic compounds and terpenoids present in alpinia galanga

A composition and compound technology, applied in directions such as pharmaceutical combinations, active ingredients of hydroxy compounds, active ingredients of heterocyclic compounds, etc., can solve problems such as extracts or concentrates of galangal galangal that have not been described yet

Inactive Publication Date: 2001-07-11
欧维塔有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] No previously described galanga extract or concentrate containing a synergistic combination of terpenoids and aromatic compounds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] research object

[0107] This study tested the inhibitory activity of the compositions according to the invention in three enzyme inhibition assays, leukotriene C4 synthase, 5-lipoxygenase and phosphodiesterase-IV. A composition comprising a 1:1 mixture of terpenoid concentrate and aromatic compound concentrate from Galanga galanga was compared with its two components to determine possible synergistic effects.

[0108] Research Overview

[0109] background

[0110] The purpose of the study was to establish the activity of the compositions according to the invention in the lipoxygenase pathway and as inhibitors of phosphodiesterase-IV (PDE-IV).

[0111]Leukotriene C4 (LTC4) synthase and 5-lipoxygenase are enzymes involved in the lipoxygenase pathway. Leukotriene C4 (LTC4) synthase is involved in the generation of LTC4 from LTA4. 5-Lipoxygenase catalyzes the oxidative metabolism of arachidonic acid to 5-hydroxyeicosatetraenoic acid (5-HETE), and the initial reaction le...

Embodiment 2

[0134] research object

[0135] This study tested the inhibitory activity of the compositions according to the invention in two enzyme inhibition assays, leukotriene C4 synthase and phosphodiesterase-IV. A composition comprising 1'-acetoxygamicol acetate and an aromatics concentrate from Galanga galanga and its two components were compared to determine possible synergistic effects.

[0136] Research Overview

[0137] background

[0138] The purpose of the study was to establish the activity of the compositions according to the invention in the lipoxygenase pathway and as inhibitors of phosphodiesterase-IV (PDE-IV).

[0139] Leukotriene C4 (LTC4) synthase and 5-lipoxygenase are enzymes involved in the lipoxygenase pathway. Leukotriene C4 (LTC4) synthase is involved in the generation of LTC4 from LTA4. 5-Lipoxygenase catalyzes the oxidative metabolism of arachidonic acid to 5-hydroxyeicosatetraenoic acid (5-HETE), and the initial reaction leads to leukotriene Triene for...

Embodiment 3

[0158] The pharmaceutical composition according to the present invention is prepared as follows.

[0159] A composition according to the invention obtained from Alpinia galanga comprising 80% aromatic compound concentrate and 20% terpene is formulated in a formulation for use as nasal drops or nasal spray according to the following prescription Compound-like concentrates:

[0160] To prepare 100g nasal spray, 1mg / ml:

[0161] a) Aromatic / terpenoid composition: 0.05 g

[0162]b) Cremophor RH 40, BASF: 2.00g

[0163] c) ethylenediaminetetraacetic acid, Fluka: 0.05g

[0164] d) Benzalkonium chloride, Sigma: 0.01g

[0165] e) Sodium chloride, Merck: 0.89g

[0166] f) Milli Q water, Millipore: 97.00g

[0167] operate:

[0168] Disperse a) into b) while heating to 37°C on a water bath; add c), d) and e). After mixing, add f) little by little with vigorous stirring.

[0169] The nasal spray prepared according to the above prescription was tested with 4 volunteers. The nasal...

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PUM

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Abstract

Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alipinia galanga (Zingiberaceae) show synergistic effects with respect to immunomodulation, and they significantly suppress hypersensitivity reactions. Thus they are used for preparing medicaments for these purposes and, more specifically, for the treatement or prevention of IgE mediated allergic reactions and conditions, such as asthma, allergic rhinitis, atopic eczema or anaphylaxis, and autoimmune disorders, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis or psoriasis, as well as for the alleviation of pain. They can for example be formulated into pharmaceuticals, cosmetics or dietary supplements. A method of preparing such compositions from Alpinia galanga is also described.

Description

field of invention [0001] The present invention relates to novel compositions containing aromatic compounds and terpenoids present in, and preferably obtainable from, the plant Alpiniagalanga (Zingiberaceae), and more particularly to Pharmaceutical, cosmetic or food supplements containing such compositions. The present invention further relates to the use of the composition for the preparation of a medicament for the treatment or prevention of hypersensitivity and diseases associated with hypersensitivity. The invention also relates to a method for preparing the composition from Alpinia galanga. Background of the invention [0002] Alpinia galanga (L.), also known as Greater Galangal or Java Galangal, is cultivated and wild in Asia. The herb is rhizome-like, 1.8-2.1 meters high, with oblong and smooth leaves and white-green flowers. The fruit is an orange-red capsule. The plant is also known as Languas galanga (great galanga), especially in Thailand where it is known loc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/30A01N31/08A61K8/33A61K8/34A61K8/36A61K8/37A61K8/49A61K8/97A61K31/015A61K31/05A61K31/075A61K31/22A61K31/225A61K31/35A61K31/36A61K31/366A61K36/18A61K36/48A61K36/9062A61K36/9068A61P1/04A61P11/02A61P11/06A61P17/00A61P17/06A61P25/04A61P29/00A61P37/02A61P37/08
CPCA61K36/48A61Q19/00A61K36/9068A61K36/9062A61K8/97A61K8/9794A61K8/9789A61P1/04A61P11/02A61P11/06A61P17/00A61P17/06A61P25/04A61P29/00A61P37/00A61P37/02A61P37/08A61K2300/00
Inventor M·S·韦德纳M·J·彼得森N·W·詹森
Owner 欧维塔有限公司
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