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Rat acarpous medicine and its preparation method

A technology of medicine and formula, which is applied in the field of mouse sterile medicine and its preparation, can solve the problems of limited anti-fertility effect, great difference in physiological conditions, sterile castor oil, etc., and achieves low price, simple extraction and pharmaceutical process, important Ingredient-specific effects

Inactive Publication Date: 2007-03-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The physiological status of female mice in the field varies greatly, and it is impossible to artificially select the designated physiological period to feed contraceptives to female mice in the field. Therefore, the anti-fertility effect of castor bean petroleum ether extract on field mice is very limited
Also, the study did not microencapsulate castor oil crude extract
[0005] Isolate and extract castor oil and castor protein, both of which can make mice sterile, from castor beans, and microencapsulate the two respectively, and then formulate them into a drug for making mice sterile, which has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] With 25 parts of castor protein microcapsules, antiseptic medicine: 1.5 parts (sodium benzoate) and bait 73.5 parts (sugar 5%, vegetable oil 3.5%, salt 0.5%, monosodium glutamate 0.1%, corn flour 38%, flour 17%, water 35% %, Prussian blue 1%) and mix evenly, then add an appropriate amount of water and stir evenly, send it into a granulator, cut into required granules, dry and pack.

[0042] Wherein said ricin and the preparation of microcapsules are as follows:

[0043] Extraction of castor protein: 500 g of the residue after extracting castor oil was mixed in phosphate buffer and homogenized. The homogenate was placed at 4°C for 24 hours. The prepared supernatant was centrifuged at 17000 g for 30 minutes, and the precipitate was discarded. Add solid ammonium sulfate to the supernatant to make it 60% saturated. Place at 4°C for 4 hours and centrifuge at 17000g for 40 minutes. The precipitate was dialyzed for 12 hours and centrifuged at 17000 g for 15 minutes at 4°C....

Embodiment 2

[0045] 10 parts of castor protein microcapsules, 35 parts of castor oil microcapsules, 1.0 parts of antiseptic drugs (sodium benzoate) and 54.0 parts of baits (composition are the same as in Example 1) are mixed uniformly, then add an appropriate amount of water and stir evenly, and send into pressed pellets Machine, cut into the desired granular shape, dry and pack.

[0046] Wherein the preparation of castor oil and microcapsules thereof is as follows:

[0047] Extraction of castor oil: 300 grams of castor beans after shelling were weighed and broken. Add 450ml of 95% ethanol to the broken castor beans, and stir in a water bath at 50°C for 75h. centrifuge at 0°C for 30 min. Prepare 380ml of supernatant. An equal amount of diethyl ether was added to the supernatant, stirred in a water bath at 60° C. for 24 hours, and concentrated to remove the dissolved drug to obtain 130 g of castor oil. Preparation of castor oil microcapsules: Stir 65g castor oil evenly at a temperature ...

Embodiment 3

[0049] Embodiment 3: 20 parts of castor protein microcapsules, 20 parts of castor oil microcapsules, 1.0 parts of antiseptic drugs (sodium benzoate) and 59.0 parts of baits (composition with embodiment 1) are mixed homogeneously, then add appropriate amount of water and stir, Send it to the granulator, cut into the required granules, dry and pack.

[0050] Wherein the preparation of described ricin and microcapsules is as embodiment 1.

[0051] Wherein the preparation of castor oil and microcapsules thereof is as embodiment 2.

[0052] Implementation Verification: Antifertility Effect of Castor Rat Sterile Agent on Rats

[0053] 1. Method: All the experimental mice are Mus musculus with a weight of 25±2 g.

[0054] 1. Anti-early pregnancy, anti-middle pregnancy:

[0055] Male and female mice were mated in a 2:1 cage, and the vaginal plug was checked every morning, and the day when the vaginal plug was found was the first day of pregnancy. The mice were taken out and fed se...

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PUM

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Abstract

A medicine for making mouse sterile is prepared from castor seed through extracting castor oil and ricin, preparing their micro capsules, and proportionally mixing them with antiseptic and attractant.

Description

1. Technical field [0001] The invention relates to a mouse sterile drug and a preparation method thereof, belonging to the field of plant-derived rodent control drugs. 2. Background technology [0002] Rodent infestation is a worldwide serious biological disaster, and controlling rodent infestation is still a major technical problem in the scientific and technological circles. After a long battle between man and mouse, the main technologies for controlling rodent damage at home and abroad include physical methods, chemical methods, microbial methods and ecological methods. Controlling pests with chemical drugs is the most common method currently used. The characteristics of chemical rodent control drugs are easy to use, quick effect, and can control the rodent damage in time when the rodent damage occurs. However, due to the strong resilience of rodent populations, chemical killing has disadvantages such as "population rebound", environmental pollution, and secondary poiso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61K9/50A61P15/18
Inventor 高平秦晓娜张小雪
Owner SICHUAN UNIV
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