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Vaginal effervescent tablets for treating woman's inflammation and their preparation

A technology for gynecological inflammation and effervescent tablets, which is applied in the field of Chinese patent medicine for treating gynecological inflammatory diseases and its preparation, which can solve the problems of high cost, inconvenient transportation and storage, and inability to extract it, so as to increase the utilization rate and improve the efficacy of the medicine , the effect of reducing production costs

Inactive Publication Date: 2007-04-04
陈志成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain defects in the above-mentioned preparation process. For example, the rhubarb in the prescription is fried and extracted with more than 2 times the amount of sesame oil in the same pan. and other components are effectively extracted, and the water-soluble components of comfrey with antibacterial and anti-inflammatory effects are not utilized, so the therapeutic effects of rhubarb, comfrey and the formula cannot be fully exerted
In addition, after extracting rhubarb and comfrey with 650ml of sesame oil, the resulting medicinal oil was less than 365ml, indicating that more than 40% of the sesame oil was lost due to adsorption of medicinal residues and other reasons, resulting in waste; The prepared Fufuling suppository must be stored below 30°C, so it is inconvenient to transport and store, so it is necessary to improve the preparation process of the drug
On the other hand, from the perspective of dosage form, there is no report on the development of Kangfuling vaginal effervescent tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of Medicinal Powder for the Treatment of Gynecological Inflammation

[0041] Raw material formula: rhubarb 248g, comfrey 100g, catechu 10g, borneol 7g.

[0042] Preparation method: (1) take rhubarb and comfrey, extract 3 times with 88% ethanol, each time for 2 hours, filter, and use the dregs for later use, add β-cyclodextrin 60g, PVPk30 60g and poloxamer 10g to the filtrate, Mix well, recover ethanol under reduced pressure, and obtain concentrated solution of alcohol extraction; take medicinal residues and add water to decoct twice, 1.5 hours each time, filter, and centrifuge the filtrate at high speed, concentrate the centrifugate to a relative density of 1.23 (60°C), and extract with alcohol The concentrates are combined, spray-dried and pulverized to obtain rhubarb and comfrey extract powder;

[0043] (2) Take borneol, 56g of β-cyclodextrin, and refer to the method [Song Hongtao, et al. Journal of Shenyang Pharmaceutical University. pink;

...

Embodiment 2

[0046] Example 2 Preparation of Medicinal Powder for Treatment of Gynecological Inflammation

[0047] Raw material formula: rhubarb 210g, comfrey 120g, catechu 12g, borneol 8g.

[0048] Preparation method: (1) get rhubarb, be crushed into coarse powder, sterilized, and ultrafinely pulverized into ultrafine powder with particle diameter≤10um to obtain rhubarb ultrafine powder;

[0049] (2) Get comfrey, extract 2 times with 95% ethanol, each time for 2.5 hours, filter, the dregs are for subsequent use, add PVPk30 70g, hydroxypropyl methylcellulose (HPMC-E5) 30g, soybean lecithin 8g to the filtrate , fully stirred evenly, recovered ethanol under reduced pressure, and concentrated to obtain a concentrated solution for alcohol extraction; take the dregs and add water to decoct twice, each time for 1 hour, filter, and the filtrate was centrifuged at a high speed, the centrifugate was concentrated to a relative density of 1.38, and extracted with alcohol The concentrates were combin...

Embodiment 3

[0052] Example 3 Preparation of Medicinal Powder for Treatment of Gynecological Inflammation

[0053] Raw material formula: rhubarb 218g, comfrey 110g, catechu 13g, borneol 6g.

[0054] Preparation method: (1) get rhubarb, be crushed into coarse powder, sterilized, and ultrafinely pulverized into ultrafine powder with particle diameter≤10um to obtain rhubarb ultrafine powder;

[0055] (2) Take comfrey, extract 3 times with petroleum ether, each time for 1.5 hours, filter, and use the dregs for later use, combine the filtrates, recover petroleum ether under reduced pressure, add 80g of PEG6000, 30g of hydroxypropyl-β-cyclodextrin to the residue , lecithin 5g, ethanol 550ml, after heating and refluxing for 40min, ethanol is recovered under reduced pressure, freeze-dried, and crushed at low temperature to obtain fine powder of solubilized matter of comfrey fat-soluble extract: take the dregs and add water to decoct twice, each time for 1.5 hours , filtered, the filtrate was cent...

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PUM

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Abstract

A vaginal effervescent tablet for treating gynecologic inflammation, such as vaginitis, cervicitis, cervical erosion, etc is prepared from rhubard, arnebia root, catechu, borneol, and the auxiliary chosen from organic acid, carbonate, filler, adhesive, disintegrant and lubricant.

Description

Technical field [0001] The invention belongs to the technical field of preparation of medicines, and in particular relates to a Chinese patent medicine for treating gynecological inflammatory diseases and a preparation method thereof. Background technique [0002] Gynecological inflammatory diseases such as adnexitis, pelvic inflammatory disease, vaginitis, cervicitis, cervical erosion, genital itching, and genital ulcers are common clinical diseases and frequently-occurring diseases. At present, there are many traditional Chinese medicine preparations for such diseases. However, due to factors such as slow or unstable curative effect, it still cannot meet the clinical needs. The variety "Fufuling Suppository" recorded in "Drug Standards of the Ministry of Health of the People's Republic of China" (eight volumes of traditional Chinese medicine preparations) is a suppository made from four traditional Chinese medicines, rhubarb, comfrey, catechu, and borneol. Dampness and in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K9/20A61K36/708A61K36/48A61K36/30A61K31/045A61P15/02A61P15/00
Inventor 陈志成
Owner 陈志成