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Chinese medicine extract for treating hepatitis and its prepn.

A technology for extracts and traditional Chinese medicines, applied in the field of preparation of the traditional Chinese medicine extracts, can solve the problems of lack of anti-HBV and the like, and achieve the effects of no toxic side effects and definite curative effect

Inactive Publication Date: 2003-01-08
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is a lack of drugs with definite anti-HBV efficacy and no side effects on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] ①Take 15 kg of cress, extract twice with 8 times the amount of 75% ethanol at reflux, extract at reflux for 1 hour each time, filter, combine the filtrate, recover the ethanol, and concentrate to a relative density of 1.02~1.08, stand still, filter, and centrifuge at high speed , Adjust the pH to 2 to 3 with dilute hydrochloric acid, extract with 6 times the volume of the concentrated solution of ethyl acetate, combine the extracts, and recover the ethyl acetate to obtain the cress extract. ②Take another 2kg of Scutellaria baicalensis Georgi, add 10 times the amount of water to decoct twice, decoct for 1 hour each time, combine the decoction liquid, concentrate to 1:4 (each 1ml is equivalent to 4g medicinal materials), adjust the pH to 1~ with dilute hydrochloric acid 2. Incubate at 80°C for 1 hour, stand still, filter, dissolve the precipitate with an appropriate amount of water, adjust the pH to 7-8 with 40% NaOH, filter, add dilute hydrochloric acid to the filtrate to ad...

Embodiment 2

[0019] ①Take 15 kg of cress, extract twice with 8 times the amount of 75% ethanol at reflux, extract at reflux for 1 hour each time, filter, combine the filtrate, recover the ethanol, and concentrate to a relative density of 1.02~1.08, stand still, filter, and centrifuge at high speed , Adjust the pH to 2 to 3 with dilute hydrochloric acid, extract with 6 times the volume of the concentrated solution of ethyl acetate, combine the extracts, and recover the ethyl acetate to obtain the cress extract. ②Take another 2kg of Scutellaria baicalensis Georgi, add 10 times the amount of water to decoct twice, decoct for 1 hour each time, combine the decoction liquid, concentrate to 1:4 (each 1ml is equivalent to 4g medicinal materials), adjust the pH to 1~ with dilute hydrochloric acid 2. Incubate at 80°C for 1 hour, stand still, filter, dissolve the precipitate with an appropriate amount of water, adjust the pH to 7-8 with 40% NaOH, filter, add dilute hydrochloric acid to the filtrate to ad...

Embodiment 3

[0022] Take the Chinese medicine extract of Example 1 and place it in a suitable container, add about 900ml of water for injection, add mannitol and stir evenly, then add water for injection to 1000ml, filter with a 0.22μm microporous membrane, and fill under sterile conditions Put part of the vial with a butadiene rubber stopper, put it on a plate, and freeze-dry it. After the freeze-drying is completed, stoppering and capping can be obtained. Example 3 Preparation of traditional Chinese medicine extract injection

[0023] Example 1 Chinese medicine extract 15g

[0024] Tween-80 1ml

[0025] Add water for injection to 1000ml

[0026] Take the traditional Chinese medicine extract of Example 1, dissolve it with 900ml of water for injection, then adjust the pH to 6-7 with 1% sodium hydroxide solution, add 1ml of Tween-80, add water for injection to 1000ml, leave it still, use 0.22μm The microporous membrane is filtered, potted, and steam sterilized, ready to be obtained....

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Abstract

The Chinese medicine extract for curing hepatitis B contains the following active components (wt%):quercetin 0.1-5, isorhamnetin 0.1-20, total chlorogenic acid 0.1-50 and baicalin 1-60. Said invention also discloses the preparation method of said Chinese medicine extract. Said invented product not only possesses the action of resisitng hepatitis virus, but also can have the action of protecting liver and reducing transaminase. Its therapeutic effect is reliable, and it has no toxic side effect.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine extract for treating hepatitis, in particular to a traditional Chinese medicine extract prepared from natural Chinese herbal medicines of cress and scutellaria baicalensis as raw materials. The invention also relates to a preparation method of the traditional Chinese medicine extract. Background technique [0002] Hepatitis B is a worldwide infectious disease caused by Hepatitis B Virus (HBV). According to statistics, there are more than 280 million people carrying hepatitis B surface antigen (HBsAg) worldwide. China is a high endemic area of ​​hepatitis B. 40% to 60% of the population has been infected with HBV, and 10% of the population (about 120 million people) are chronic HBsAg carriers. According to surveys, there are more than 30 million patients suffering from chronic hepatitis B in China, of which 25%-40% develop cirrhosis or liver cancer. Every year, 400,000 people die of liver cirrhosis afte...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/16A61P31/12
Inventor 张晴龙
Owner 张晴龙
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