Halenia elliptica D.Don extract and preparation method, pharmaceutical composition and application thereof

An extract, composition technology

Active Publication Date: 2011-08-03
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the anchovy extract obtained by the method reported in the prior art only includes water-soluble ketone glycoside components

Method used

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  • Halenia elliptica D.Don extract and preparation method, pharmaceutical composition and application thereof
  • Halenia elliptica D.Don extract and preparation method, pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 flower anchor extract of the present invention

[0037] Take 3.5 kg of flower anchor medicinal material (dried aerial part or whole plant), heat and reflux extraction with 10 times the amount of 95% ethanol for 3 times (2h, 1h, 1h), collect the extract; concentrate at low temperature and reduced pressure to about 9 liters, and pour Add about 10 times the volume of distilled water to the solution for precipitation, after standing overnight, centrifuge to obtain supernatant (filtrate) and precipitation. The supernatant was passed through HPD-300 type macroporous adsorption resin, first eluted to colorless with 8BV (column volume) water and 8BV (column volume) 20% ethanol, removed macromolecular impurities such as sugar, discarded, and then washed with 5BV ( column volume) 95% ethanol, collect the ethanol eluate, and dry the eluate after recovering ethanol under reduced pressure to obtain part 1 (component 1); the precipitate is stirred and...

Embodiment 2

[0041] Embodiment 2 Preparation of flower anchor extract of the present invention

[0042] Take 3.5 kg of flower anchor medicinal material (dried aerial part or whole plant), heat and reflux extract with 5 times the amount of 40% ethanol once (1h), collect the extract; concentrate under low temperature and reduced pressure to about 9 liters, add about Precipitate with 1 times the volume of distilled water, stand overnight, and centrifuge to obtain supernatant (filtrate) and precipitate. The supernatant was passed through HPD-100 type macroporous adsorption resin, and was first eluted to colorless with 2BV (column volume) water and 2BV (column volume) 5% ethanol, removed macromolecular impurities such as sugar, discarded, and then washed with 5BV ( column volume) 20% ethanol, collect the ethanol eluate, and dry the eluate after recovering ethanol under reduced pressure to obtain part 1 (component 1); the precipitate is ultrasonically degreased with petroleum ether, and the de...

Embodiment 3

[0046] Embodiment 3 Preparation of flower anchor extract of the present invention

[0047] Take 3.5 kg of flower anchor medicinal material (dried aerial part or whole plant), heat and reflux extraction twice (2h, 2h) with 7 times the amount of 60% ethanol, collect the extract; concentrate at low temperature and reduced pressure to about 9 liters, pour into the concentrate Add about 5 times the volume of distilled water for precipitation, stand overnight, and centrifuge to obtain supernatant (filtrate) and precipitation. The supernatant was passed through the D-101 type macroporous adsorption resin, and first eluted to colorless with 5BV (column volume) water and 5BV (column volume) 15% ethanol, removed macromolecular impurities such as sugar, discarded, and then washed with 5BV (column volume) column volume) 50% ethanol, collect the ethanol eluate, and dry the eluate after recovering ethanol under reduced pressure to obtain part 1 (component 1); the precipitate is extracted ...

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PUM

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Abstract

The invention provides halenia elliptica D.Don extract which contains 10-80% of xanthone by weight of total content and 10-80% of triterpenoid by weight of total content of which the content sum is 50-95% by weight. The halenia elliptica D.Don extract provided by the invention has obvious curative effects on hepatopathy, and can be used in medicaments for treating hepatopathy such as viral hepatitis, alcohol liver disease, fatty liver, drug induced liver injury, immunological liver injury and the like. The invention also provides a preparation method and a pharmaceutical composition of the halenia elliptica D.Don extract.

Description

technical field [0001] The present invention belongs to the field of medicine, and in particular relates to a flower anchor extract and a preparation method thereof, a pharmaceutical composition containing the flower anchor extract and use thereof. Background technique [0002] Liver diseases, such as viral hepatitis, fatty liver, alcoholic liver disease, drug-induced liver damage and liver cancer, are one of the major diseases that threaten human health today. growing trend year by year. my country is a big country with hepatitis. According to statistics, there are currently 120 million hepatitis B virus carriers in my country, and about 30-40 million chronic hepatitis B patients. Such a large patient group has created an attractive drug market for liver disease. According to industry experts, the current domestic liver drug The market capacity is about 10 billion yuan, of which Chinese patent medicine preparations account for more than 2 billion yuan. Therefore, the preve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/00A61P1/16A61P31/14A61P31/20A61P37/00
Inventor 张铁军王丽莉田成旺刘黄刚许浚
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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