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Water cress extract and its preparing method and use

A technology of extract and cress, applied in the field of application in the preparation of drugs for the treatment of hepatitis B, to achieve a definite curative effect

Inactive Publication Date: 2003-01-22
张在雪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is still a lack of new drugs with definite anti-HBV curative effect and no side effects on the market.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 watercress extract 12 grams

[0024] Mannitol 20g

[0025] Take the cress extract of Example 1, put it in a suitable container, add about 900ml of water for injection, add mannitol and stir evenly, then add water for injection to 1000ml, filter it with a 0.22 μm microporous membrane, and pour it under sterile conditions Put it in a vial, partially plug it with a butyl rubber stopper, put it on a plate, and freeze-dry it. After the freeze-drying is finished, stoppering and capping are ready. The preparation of embodiment 5 cress extract injection

Embodiment 2

[0026] Embodiment 2 watercress extract 12g

[0027] Tween-80 1ml

[0028] Add water for injection to 1000ml

[0029] Take the cress extract of Example 2, dissolve it with 900ml of water for injection, then adjust the pH to 6-7 with 1% sodium hydroxide solution, add 1ml of Tween-80, add water for injection to 1000ml, let it stand, and use 0.22 The microporous membrane of μm is filtered, potted, steamed and sterilized, and the product is obtained. The preparation of embodiment 6 cress extract capsules

[0030] Embodiment 2 watercress extract 650g

[0031] Dextrin 275g

[0032] Sodium Carboxymethyl Cellulose 60g

[0033] Magnesium Stearate 15g

[0034] Take the cress extract of Example 2, dextrin, sodium carboxymethylcellulose, and magnesium stearate, mix evenly, pass through an 80-mesh sieve, granulate with a dry granulator, granulate with a 60-mesh sieve, and pour into capsules , that is. The preparation of embodiment 7 cress extract tablet

[0035] Embodiment 1 waterc...

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Abstract

The water cress extract contains active components including quercetin, isorhamnetin, general chlorogenic acid. The preparation process of the water cress extract includes the following steps: refluxextractio of water cress material in solvent, merging extracted liquid, filtering, concentrating the filtrate, letting stand, filtering, separation to eliminate the impurity in the filtrate, concentration and drying. The water cress extract is used in treating hepatitis B and has the functions of resisting hepatitis virus, protecting liver and reducing alanine aminotransferase. It has definite curative effect and no toxic side effect.

Description

Technical field [0001] The invention relates to a cress extract, and also relates to a preparation method of the cress extract and its application in the preparation of a medicine for treating hepatitis B. Background technique [0002] Hepatitis B is a worldwide infectious disease caused by Hepatitis B Virus (HBV for short). According to statistics, the number of people carrying hepatitis B surface antigen (HBsAg) in the world exceeds 280 million. China is a high prevalence area of ​​hepatitis B, 40% to 60% of the population has been infected with HBV, and 10% of the population is chronic HBsAg carriers. According to the survey, there are more than 30 million patients suffering from chronic hepatitis B in China, and more than 25% to 40% of them develop liver cirrhosis or liver cancer. Among the various cancers that threaten the health of our people, liver cancer ranks first, and about 90,000 to 100,000 people die of liver cancer every year. The pathogenesis of chronic hep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/352A61P1/16A61P31/12C07C67/56C07C69/732C07D311/30
Inventor 张在雪
Owner 张在雪
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