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Chinese medicine extract for treating fatty liver, obesity and its preparation method

An extract and obesity technology, applied in the field of medicine, can solve the problems of lack of curative effect on obesity, and achieve the effect of no toxic side effects and definite curative effect

Inactive Publication Date: 2006-10-04
JILIN SCI TECH INFORMATION INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is a lack of drugs on the market that are effective in treating fatty liver and obesity without side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Chinese medicine extract:

[0024] ①Take 15 kg of willow leaf traditional Chinese medicine, reflux extraction with 8 times the amount of 75% ethanol for two times, each reflux extraction for 1 hour, filter, combine the filtrate, recover the ethanol, concentrate to a relative density of 1.02-1.08, let stand, filter, Centrifuge at high speed, adjust the pH to 2-3 with dilute hydrochloric acid, extract with ethyl acetate 6 times the volume of the concentrated solution, combine the extracts, recover the ethyl acetate to obtain the willow leaf extract. ② Take another 2kg of Astragalus membranaceus, add 10 times the amount of water to decoct twice, decoct for 1 hour each time, combine the decoction liquid, concentrate to 1:4 (each 1ml is equivalent to 4g of medicinal materials), and adjust the pH to 1~2 with dilute hydrochloric acid. 2. Incubate at 80°C for 1 hour, let it stand, filter, dissolve the precipitate with appropriate amount of water,...

Embodiment 2

[0025] The preparation of embodiment 2 Chinese medicine extract powder injection:

[0026] Example 1 Chinese medicine extract 15 grams

[0027] Mannitol 20g

[0028] Take the Chinese medicine extract of Example 1, put it in a suitable container, add about 900ml of water for injection, add mannitol and stir evenly, then add water for injection to 1000ml, filter with a 0.22um microporous membrane, and fill it under sterile conditions In vials, partly plugged with butyl rubber stoppers, packed into plates, and freeze-dried. After the freeze-drying is finished, stoppering and capping are ready.

Embodiment 3

[0029] The preparation of embodiment 3 Chinese medicine extract injection liquid

[0030] Example 1 Chinese medicine extract 15g

[0031] Tween-80 1ml

[0032] Add water for injection to 1000mt

[0033]Take the Chinese medicine extract of Example 1, dissolve it with 900ml of water for injection, then adjust the pH to 6-7 with 1% sodium hydroxide solution, add 1ml Tween-80, add water for injection to 1000ml, let it stand, and use 0.22um The preparation is obtained by filtering with a microporous membrane, potting, and sterilizing by flowing steam.

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PUM

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Abstract

A Chinese medicine for treating fatty liver and obesity is prepared from astragalus root and willow leaf through reflux extracting of willow leaves in alcohol, decocting astragalus roots in water, adding diluted acid, filtering to obtain deposit, mixing it with the extract of willow leaf, vacuum drying and pulverizing.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine extract for treating fatty liver and obesity and an improved preparation method. Background technique: [0002] The liver is an important place for fat metabolism. When the liver's ability to synthesize fat and / or reduce its ability to transport into the blood, excessive accumulation of lipids (mainly triglycerides) in the liver exceeds 5% of the weight of the liver, or more than 50% histologically When the liver parenchyma becomes fatty, it is fatty liver. Fatty liver is not an independent disease, but fatty degeneration of the liver caused by various diseases and reasons. The most common causes are obesity, alcoholism, and diabetes; followed by malnutrition, drug poisoning, pregnancy, and genetics. [0003] With the continuous improvement of human material life, the incidence of fatty liver has been increasing year by year. It has accounted for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/185A61K36/481A61P1/16A61P3/04C07H1/08
Inventor 昌友权李云彪王雪李晶
Owner JILIN SCI TECH INFORMATION INST
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