Use of centella total glycoside in manufacture of medicine

A kind of technology of total asiaticosides and uses, applied in the field of total asiaticosides

Inactive Publication Date: 2003-07-16
HANGZHOU SHARPLY PHARM R&D INSTIT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported that it is used to treat other diseases

Method used

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  • Use of centella total glycoside in manufacture of medicine
  • Use of centella total glycoside in manufacture of medicine
  • Use of centella total glycoside in manufacture of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Centella asiatica was decocted twice with 10 times the amount of water, each time for 3 hours, and then added with 8 times the amount of water for 2 times, each time for 3 hours. The combined filtrates were filtered, concentrated under reduced pressure in vacuo, added ethanol, adjusted the pH to 9 with ammonia water, and allowed to settle. Filter, neutralize the filtrate with dilute sulfuric acid, add active decolorization. Filtrate, extract the filtrate with an organic solution, decolorize the extract, concentrate and dry to obtain asiatica glycosides.

[0061] Take 6 grams of Centella asiaticosides, crush them through a 100-mesh sieve, add 20 grams of starch and 54 grams of dextrin that have passed through a 100-mesh sieve and mix well, then pass through a 100-mesh sieve, add an appropriate amount of 50% ethanol and mix well, pass through a 16-mesh sieve Granulate with wire mesh, dry and granulate below 60°C, add appropriate amount of magnesium stearate, m...

Embodiment 2

[0062] Example 2: The preparation of asiaticosides was consistent with Example 1. Grind 999 grams of lactose for later use. Grind 0.5 g of Centella asiaticosides and 0.5 g of 1% carmine lactose evenly, then gradually add the required lactose according to the equal amount incremental mixing method, fully grind and mix, and divide into 12 servings after the whole color is uniform. A powder containing 6mg of asiaticoside.

Embodiment 3

[0063] Example 3: The preparation of asiaticosides was consistent with Example 1. Centella asiaticoside 1g, crushed through a 100-mesh sieve, added 1974g of sucrose powder passed through a 100-mesh sieve, 25g of microcrystalline cellulose, mixed evenly, passed through a 100-mesh sieve, and granulated through a 16-mesh iron sieve , dried below 60°C, granulated, and coated with a coating solution. It can be made into granules containing 6 mg of asiaticoside in 12 grams per bag.

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Abstract

A novel application of centella asiatica to preventing and treating mastoplasia is disclosed.

Description

[0001] Involved areas [0002] The present invention relates to the application of asiaticoside, in particular to the application in the field of pharmacy. Background technique [0003] The total glycosides of Centella asiatica is the extract of Centella asiatica, a Chinese herbal medicine, and its main components are asiaticoside and hydroxyasiaticoside. Molecular formula of asiaticoside: C 48 h 78 o 19 , the molecular weight is 958. The chemical structural formula is: Hydroxy asiaticoside molecular formula: C 48 h 78 o 20 , the molecular weight is 974. The chemical structural formula is: [0004] It has the function of activating epithelial cells, promoting the formation of normal granulation tissue, and can make the wound surface heal quickly; it can inhibit the proliferation of fibroblasts, inhibit and alleviate the disordered keloid hyperplasia, prevent the occurrence of adhesions and relieve the formation of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P15/08
Inventor 胡刚李皓张小慧李萍顾兵丁建花
Owner HANGZHOU SHARPLY PHARM R&D INSTIT
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