Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Usage of total alkaloid of coftis root, phellodendron bark and ÔÇÿSankezhenÔÇÖ as their preparing method

A technology of total alkaloids and three needles, applied in the field of medicine, can solve problems such as drugs that have not been found for diabetes

Inactive Publication Date: 2003-10-01
CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
View PDF7 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of medicines for the treatment of diabetes in Western medicine, but so far, no medicine that can completely cure diabetes has been found.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Usage of total alkaloid of coftis root, phellodendron bark and ÔÇÿSankezhenÔÇÖ as their preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: 1 kg of Coptis chinensis, a Chinese herbal medicine, was cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered through 8 layers of gauze, and the filtrate was neutralized to pH 7.0-8.0 with sodium hydroxide. The neutralized extract was passed through a macroporous adsorption resin column, the inorganic salts and water-soluble impurities were washed away with water, and then 120 g of total alkaloids were obtained by eluting with 60% and 95% ethanol, with a yield of 12%. Its effect on the glucose uptake function of differentiated C2C12 myoblasts is shown in Figure 1:

Embodiment 2

[0018] Example 2: 1 kg of Phellodendron Phellodendri, cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered with 8 layers of gauze, and the filtrate was neutralized to pH 7.0 to 8.0 with sodium hydroxide. The effect of the neutralized extract on the uptake of glucose by differentiated C2C12 cells was firstly washed with water to remove inorganic salts and water-soluble impurities, and then eluted with 60% and 95% ethanol to obtain 67g of total alkaloids, with a yield of 6.7 %. Its effect on the glucose uptake function of differentiated C2C12 cells is shown in Figure 2:.

Embodiment 3

[0019] Example 3: 1 Kg of the three needles of traditional Chinese medicine was cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered through 8 layers of gauze, and the filtrate was neutralized to pH 7.0-8.0 with sodium hydroxide. The neutralized extract was passed through a macroporous adsorption resin column, the inorganic salts and water-soluble impurities were washed away with water, and then 38 g of total alkaloids were obtained by eluting with 60% and 95% ethanol, with a yield of 3.8%. Its effect on the glucose uptake function of differentiated C2C12 myoblasts is shown in Figure 3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The application and preparing process for the common alkaloids of coptis root, phellodendron bark and berberis root are disclosed. Said common alkaloid is prepared from its raw material through extracting and drying. They can be used to prepare the medicines for treating diabetes and hyperlipemia.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to the use of total alkaloids of Coptidis Rhizome, Phellodendron Phellodendron and Sankezhen and its preparation method. Background technique: [0002] Diabetes is one of the common diseases that seriously threaten human health. According to the fifth International Diabetes Federation Western Pacific Conference held in Beijing, there are currently 130 million people with type II diabetes diagnosed worldwide, and more than 40 million people in my country; type II diabetes will be developed in China, India and other developing countries in the 21st century. It is prevalent in the country. By 2005, the number of diabetic patients in the world will exceed 300 million. The total number of diabetic patients in my country is close to 100 million, becoming the second largest country in the world in terms of the number of diabetic patients after India. In 1994, the medical expenses for dia...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4375A61P3/06A61P3/10A61P19/10
Inventor 姚新生苏京邱峰王晶曲戈霞王保平
Owner CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com