Usage of total alkaloid of coftis root, phellodendron bark and ÔÇÿSankezhenÔÇÖ as their preparing method

A technology of total alkaloids and three needles, applied in the field of medicine, can solve problems such as drugs that have not been found for diabetes

Inactive Publication Date: 2003-10-01
CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are many kinds of medicines for the treatment of diabetes in Wester

Method used

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  • Usage of total alkaloid of coftis root, phellodendron bark and ÔÇÿSankezhenÔÇÖ as their preparing method

Examples

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Effect test

Embodiment 1

[0017] Example 1: 1 kg of Coptis chinensis, a Chinese herbal medicine, was cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered through 8 layers of gauze, and the filtrate was neutralized to pH 7.0-8.0 with sodium hydroxide. The neutralized extract was passed through a macroporous adsorption resin column, the inorganic salts and water-soluble impurities were washed away with water, and then 120 g of total alkaloids were obtained by eluting with 60% and 95% ethanol, with a yield of 12%. Its effect on the glucose uptake function of differentiated C2C12 myoblasts is shown in Figure 1:

Embodiment 2

[0018] Example 2: 1 kg of Phellodendron Phellodendri, cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered with 8 layers of gauze, and the filtrate was neutralized to pH 7.0 to 8.0 with sodium hydroxide. The effect of the neutralized extract on the uptake of glucose by differentiated C2C12 cells was firstly washed with water to remove inorganic salts and water-soluble impurities, and then eluted with 60% and 95% ethanol to obtain 67g of total alkaloids, with a yield of 6.7 %. Its effect on the glucose uptake function of differentiated C2C12 cells is shown in Figure 2:.

Embodiment 3

[0019] Example 3: 1 Kg of the three needles of traditional Chinese medicine was cold-soaked with 5 L of 2% sulfuric acid aqueous solution for 24 hours, then filtered through 8 layers of gauze, and the filtrate was neutralized to pH 7.0-8.0 with sodium hydroxide. The neutralized extract was passed through a macroporous adsorption resin column, the inorganic salts and water-soluble impurities were washed away with water, and then 38 g of total alkaloids were obtained by eluting with 60% and 95% ethanol, with a yield of 3.8%. Its effect on the glucose uptake function of differentiated C2C12 myoblasts is shown in Figure 3.

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Abstract

The application and preparing process for the common alkaloids of coptis root, phellodendron bark and berberis root are disclosed. Said common alkaloid is prepared from its raw material through extracting and drying. They can be used to prepare the medicines for treating diabetes and hyperlipemia.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to the use of total alkaloids of Coptidis Rhizome, Phellodendron Phellodendron and Sankezhen and its preparation method. Background technique: [0002] Diabetes is one of the common diseases that seriously threaten human health. According to the fifth International Diabetes Federation Western Pacific Conference held in Beijing, there are currently 130 million people with type II diabetes diagnosed worldwide, and more than 40 million people in my country; type II diabetes will be developed in China, India and other developing countries in the 21st century. It is prevalent in the country. By 2005, the number of diabetic patients in the world will exceed 300 million. The total number of diabetic patients in my country is close to 100 million, becoming the second largest country in the world in terms of the number of diabetic patients after India. In 1994, the medical expenses for dia...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P3/06A61P3/10A61P19/10
Inventor 姚新生苏京邱峰王晶曲戈霞王保平
Owner CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
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