Composition of danazol semisolid skeleton preparation

Abstract

The present invention discloses a composition of danazol semi-solid skeleton preparation, its composition includes danazol 0.5-10 wt%, surfactant whose HLB is greater than above 12 1-98.5 wt% and carrier of semi-solid skeleton 1-98.5%. Said composition is good is dissolution property, can be used for curing endometriosis, and can have obvious therapeutic effect, also can be used for fibroadenosis, spontaneous thrombopenic purpura, heteditary angioneuotic edema and systemic lupus erythematosus. Said invention possesses the features of low dosage, quick absorption, high blood concentration and biological utilization.

Description

technical field [0001] The invention relates to a danazol preparation. Background technique [0002] Danazol, its English name is Danazol Soft Capsules, its chemical name is 17α-pregna-2,4-dien-20-alkyno[2,3-d]isoxazole-17β-alcohol, and its structural formula is as follows : [0003] Molecular formula: C 22 h 27 NO 2 , molecular weight: 337.46. [0004] Danazol is a gonadotropin inhibitor that inhibits the pituitary-ovarian axis. The release of follicle-stimulating hormone and luteinizing hormone is reduced due to suppression of pituitary gonadotropins. It can directly inhibit the production of ovarian steroid hormones, act on the estrogen receptors of endometrial cells, have the effect of inhibiting estrogen, and inactivate and shrink the normal and abnormal endometrium of the uterus, resulting in anovulation and amenorrhea, which can Lasts for 6-8 months. [0005] Danazol is used to treat endometriosis that cannot be tolerated or is ineffective for other drugs, a...

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved in the present invention is to disclose a semi-solid matrix preparation (Semi Solid Matrix) of danazol, that is, a substance with a waxy melting point is added to the medicinal liquid, which can be melted at high temperature and solid at room temperature. , compared with the traditional powder particle filling, it can avoid the flying of drug powder (especially for hormone and anticancer drugs); the filling amount is uniform, the main drug dosage is accurate; the drug or liquid is dispersed in the excipient and mixed with air and humidity Gas isolation, so it is more stable; proper adjustment of the prescription can obtain the desired high bioavailability, in order to make the pharmacologically active substance progesterone better absorbed in the body, achieve good curative effect and reduce adverse reactions at a lower dose