Triterpene extracts from achyranthes roots and their use in medicine against osteoporosis

An anti-osteoporosis, extract technology, applied in drug combination, medical preparations containing active ingredients, bone diseases, etc., can solve the problem of anti-osteoporosis that has not been reported, and achieve the effect of less side effects

Inactive Publication Date: 2004-02-04
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing patent applications related to total steroid extract for immunological use, but no report on its anti-osteoporosis

Method used

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  • Triterpene extracts from achyranthes roots and their use in medicine against osteoporosis
  • Triterpene extracts from achyranthes roots and their use in medicine against osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The dried root (300g) of Achyranthes bidentata Bl. was crushed, heated to reflux with 70%~100% ethanol (600ml), and extracted three times. The extracts were combined and concentrated under reduced pressure to remove the solvent in the extract to obtain ethanol extract (about 79.33 g, 26.44%). Suspend the extract in distilled water (500ml), add n-hexane (500ml x 3 times) for extraction, and combine the extracts to obtain n-hexane extract.

[0017] It is also possible to add petroleum ether (500ml×3 times) for extraction after n-hexane extraction, and combine the extracts to obtain petroleum ether extract. This extraction can also directly replace n-hexane extraction, and when n-hexane extraction is used, this extraction can also be ignored.

[0018] Then with ethyl acetate (500ml * 3 times) respectively, n-butanol (500ml * 3 times) and water extraction with remaining medicinal extract distilled water suspension respectively, obtain ethyl acetate, n-butanol extract. Ext...

Embodiment 2

[0026] n-hexane extract

[0027] The results clearly show that the n-hexane extract of Achyranthes bidentata obtained in Example 1 has no inhibitory effect on the hyperabsorption induced by parathyroid hormone.

Embodiment 3

[0029] The ethyl acetate extract of Achyranthes bidentata obtained in Example 1 is formulated into 5 kinds of concentrations described in the following table the same as Example 2, 440; 44; 4.4; 0.88 and 0.44 micrograms / ml.

[0030] Ethyl acetate extract

[0031] The results clearly show that the ethyl acetate extract of Achyranthes bidentata obtained in Example 1 has a strong inhibitory effect on hyperabsorption induced by parathyroid hormone.

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Abstract

A process for extracting triterpenoid from the dried root of Achyranthes bidentata includes such steps as pulverizing, hot reflux extracting in alcohol, extracting with ethyl acetate 1-4 times, mixing with distilled water, extracting with n-butanol 1-4 times and extracting with water. The liquid extract can be used to treat osteoporosis, especially the osteoporosis of women, with high curative effect.

Description

1. Technical field [0001] The present invention relates to the application of triterpenes (including triterpene glycosides) extract obtained from common traditional Chinese medicine Achyranthes bidentata (root of Achyranthes bidentata Bl.) as an anti-osteoporosis drug. 2. Background technology [0002] Osteoporosis is a common middle-aged and elderly disease characterized by decreased bone tissue mass and microstructural degradation, resulting in increased bone fragility and susceptibility to fractures. With the development of human society and the advancement of medical science and technology, the life expectancy of human beings has been greatly improved, making the aging of society increasingly serious. More and more people will suffer from osteoporosis. According to the National Osteoporosis Foundation (NOF, National Osteoporosis Foundation) report, there are 10 million osteoporosis patients and more than 18 million low bone density patients (future osteoporosis patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P19/10C07J63/00
Inventor 李建新门田重利
Owner NANJING UNIV
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