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Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method

A technology of coronary heart disease angina pectoris and traditional Chinese medicine paste, which is applied in the fields of medical formulas, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve the problems of limited drug transdermal absorption, low drug loading, and patient discomfort, etc., to achieve Improve myocardial ischemia hypoxia supply and demand balance, blood drug concentration and lasting, increase coronary blood flow effect

Inactive Publication Date: 2004-04-28
马德林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although this medicine bag has a certain curative effect, because it does not directly contact the medicine with human skin, it limits the transdermal absorption of the medicine, and what is really absorbed by the skin is only some volatile components, so it seriously affects the clinical efficacy.
Other topical plasters that use traditional Chinese medicine have the following insurmountable problems. Because of the weak medicinal properties of traditional Chinese medicine, the active ingredient extract of traditional Chinese medicine is dispersed in the polymer gel, which not only has a small drug load, but also has a slow release rate of the active ingredient of the drug, resulting in blood poisoning. The concentration is low, so it can only treat body surface diseases, and cannot meet the requirements of preventing and treating coronary heart disease; in the preparation of externally-used Chinese medicine ointment, it is usually dried and molded at above 60°C, which destroys the active ingredients of Chinese medicine and affects the curative effect of externally-used Chinese medicine dosage forms
The external dosage form made of a mixture of polymer medicinal glue and drugs is easy to adhere tightly to the skin when it is applied externally, making the skin airtight, affecting the normal metabolism of the local skin and excretion of secretions, and patients also feel uncomfortable, so it is not suitable for long-term application.
The above-mentioned technical problems make it very difficult to prepare effective drugs for the prevention and treatment of coronary heart disease in the external dosage form of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of externally applied traditional Chinese medicine film for preventing and treating coronary heart disease angina pectoris

[0032] a) Weigh the Chinese herbal medicine according to the following dosage:

[0033] Styrax 234g, borneol 87g, benzoin 87g and calamus 87g;

[0034] Boil Shichangpu with water for 10-12 hours, extract the distilled volatile oil, filter the boiled liquid, concentrate the filtrate into a thick paste, add 60% ethanol, stir well until it is completely uniform, let it stand for 24 hours, absorb the supernatant liquid, the precipitate part was filtered, the filtrate was decompressed, ethanol was recovered, and then concentrated into a thick paste for later use;

[0035] b) The benzoin was extracted twice with 9 times the amount of ethanol under reflux, each time for 1 hour, filtered, the two filtrates were combined and reduced pressure, the ethanol was recovered, and the medicinal solution was concentrated into a thick ointment...

Embodiment 2

[0041] Example 2 Preparation of externally applied traditional Chinese medicine film for preventing and treating coronary heart disease angina pectoris

[0042] a) Weigh Chinese herbal medicines according to the following dosage: Styrax 234g, Borneolum 87g, Benzoin 87g, Shichangpu 87g, Cyperus cyperi 87g, Muxiang 87g, Agarwood 87g, Sandalwood 87g, Agarwood 45g, Angelica dahurica 87g, Clove 45g and Allium scallion 87g ;

[0043] b) Boil Cyperus Cyperi, Woody Fragrance, Dalbergia, Sandalwood, Agarwood, Angelica, Clove, Allium, and Calamus with water for 10 to 12 hours, extract the distilled volatile oil, filter the boiling liquid, and concentrate the filtrate into Thick paste, add 60% ethanol, fully stir until it is completely uniform, let it stand for 24 hours, absorb the supernatant, filter the precipitated part, depressurize the filtrate, recover ethanol, and concentrate it into a thick paste for later use;

[0044] c) adding 9 times the amount of ethanol to the benzoin trad...

Embodiment 3

[0050] Example 3 Preparation of externally applied traditional Chinese medicine film for preventing and treating coronary heart disease angina pectoris

[0051] a) Weigh the Chinese herbal medicine according to the following dosage:

[0052] Styrax 234g, Borneol 87g, Benzoin 87g, Shichangpu 87g, Cyperus cyperi 87g, Woody incense 87g, Dalbergia 87g, Sandalwood 87g, Agarwood 45g, Angelica dahurica 87g, Clove 45g, Chuanxiong 234g, Salvia miltiorrhiza 234g, Panax notoginseng 234g, Angelica 87g , Radix Paeoniae Rubra 87g, Frankincense 87g, Myrrh 87g, Yuanhu 87g, Curcuma 87g and Scallion 87g;

[0053] b) Boil Chuanxiong, Sandalwood, Tulip, Woody, Clove, Angelica, Shichangpu, Cyperus Cyperi, Dalbergia, Allium, Agarwood, Angelica, Frankincense, and Myrrh with water for 10-12 hours, extract and distill volatile oil, boiled liquid was filtered, the filtrate was concentrated into a thick paste, the amount of ethanol was added to 60%, fully stirred until it was completely uniform, allowe...

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Abstract

The Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris consists of back lining material, medicine layer and protecting film. The medicine layer consists of skeleton supplementary material, effective Chinese medicine extractive and plasticizer; and the effective Chinese medicine extractive is ointment of extractive of Chuanxiong rhizome, sandalwood, nutagrass flatsedge rhizome, dalbergia wood, frankincense, kudzu vine root, etc. The Chinese medicine adhesive film is adhered to left chest for transdermal absorption to act on heart, and can dilate coronary blood vessel, improve blood flow of coronary blood vessel, improve heart function and prevent hidden coronary heart disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine sticking film for preventing and treating angina pectoris of coronary heart disease and a process preparation method of the sticking film. technical background [0002] Coronary heart disease is a common and frequently-occurring disease of humans, especially middle-aged and elderly people, and is the first disease that causes human death worldwide. With the aging of human society, the development of economy and the improvement of living standards, the incidence rate is increasing day by day and gradually becoming younger. Most of the patients who go to the hospital for medical treatment in the society are in the middle and late stages, with obvious symptoms and cardiac ischemic changes, and need active treatment. Another part of the population suffers from recessive coronary heart disease and has no obvious symptoms, but once stimulated by different external fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61P9/10
Inventor 马德林
Owner 马德林
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