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Shishan alkaloid drip pill and its preparation method

A technology of Huperzine A and dropping pills, applied in the directions of pill delivery, nervous system diseases, drug combination, etc., can solve the problem of long disintegration time of Huperzine A tablets or capsules, affecting the therapeutic effect and dissolution rate of Huperzine A and low dissolution rate, etc., to achieve the effects of convenient carrying and taking, small pill size, and improved dissolution rate and dissolution rate.

Inactive Publication Date: 2004-05-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because huperzine A is insoluble in water, tastes slightly bitter, has hygroscopicity and strong hydrophobicity, the disintegration time of huperzine A tablets or capsules is long, the dissolution rate and dissolution rate are low, the absorption is poor, and the bioavailability is low. The dosage is large, children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take, and the compliance is poor, which affects the therapeutic effect of huperzine A

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Huperzine A 50mg

[0054] Mannitol 5g

[0055] Macrogol 6000 15g

[0056] Makes 1000 capsules

[0057] Preparation method: Take the mixed fine powder of huperzine A and mannitol that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, and make it by drop method Pills, dried, ready to use.

example 2

[0059] prescription:

[0060] Huperzine A 50mg

[0061] Mannitol 5g

[0062] Macrogol 4000 15g

[0063] Makes 1000 capsules

[0064] Preparation method: Take the mixed fine powder of huperzine A and mannitol that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, and make it by drop method Pills, dried, ready to use.

example 3

[0066] prescription:

[0067] Huperzine A 50mg

[0068] Mannitol 5g

[0069] Macrogol 6000 5g

[0070] Macrogol 4000 10g

[0071] Makes 1000 capsules

[0072] Preparation method: Take the mixed fine powder of huperzine A and mannitol that has been superfinely pulverized and passed through a 200 mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 kunning matrix, stir well, and add dimethyl Silicone oil is used as a cooling agent, and the pills are prepared by dripping, and dried.

[0073] 4. Example 4

[0074] prescription:

[0075] Huperzine A 50mg

[0076] Mannitol 5g

[0077] Glyceryl monostearate 15g

[0078] Makes 1000 capsules

[0079] Preparation method: Take the mixed fine powder of huperzine A and mannitol that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix...

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PUM

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Abstract

A dripping pill of huperzine A and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its effect, stability and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to huperzine A dripping pills and a preparation method thereof. Background technique [0002] Huperzine A is a cholinesterase inhibitor that selectively inhibits true ChE and easily passes through the blood-brain barrier. It has the effect of promoting memory reproduction and enhancing memory retention. [0003] Animal experiments show that oral absorption of huperzine A is rapid and complete, distribution is also fast, and distribution phase half-life (t 1 / 2α ) is 9.8 minutes, high bioavailability, slow excretion, elimination phase half-life (t 1 / 2β ) for 247.5 minutes, mainly excreted through urine in the form of prototype and metabolites. It is clinically used for benign memory disorders to improve the ability of patients to point to memory, associative learning, image recall, meaningless graphic recognition and portrait recall. It can also impr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/439A61P25/28A61P43/00
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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