Anti beta-bactamase antibiotic compound prepn.

A technology of lactamase antibiotics and compound preparations, which is applied in the field of anti-β-lactamase antibiotic compound preparations to achieve the effects of strong antibacterial effect and broad antibacterial spectrum

Inactive Publication Date: 2004-07-21
SHENZHEN SALUBRIS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the marketing and clinical application of cefuroxime and its salts, sulbactam and its salts, or tazobactam and its salts as new drugs at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Preparation of cefuroxime and sulbactam compound preparation

[0013] Mix 1 g of cefuroxime sterile powder and 1 g of sulbactam sterile powder, and operate according to known powder injection or freeze-dried powder injection process procedures.

Embodiment 2

[0014] Embodiment 2: Preparation of cefuroxime sodium and sulbactam compound preparation

[0015] Mix 1 g of cefuroxime sodium sterile powder and 0.5 g of sulbactam sterile powder, and operate according to the known powder injection or freeze-dried powder injection process.

Embodiment 3

[0016] Embodiment 3: Preparation of cefuroxime potassium and sulbactam compound preparation

[0017] Mix 1 g of cefuroxime potassium sterile powder and 0.25 g of sulbactam sterile powder, and operate according to the known powder injection or freeze-dried powder injection process.

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PUM

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Abstract

A compound anti-beta-lactamase antibiotic is prepared from cefuroxime or its salt, sulbactam or its salt, and tazobactan or its salt. Its advantages are broad spectrum and high antibacterial effect.

Description

technical field [0001] The invention relates to an anti-β-lactamase antibiotic compound preparation, in particular to a compound preparation composed of cefuroxime and its salt, sulbactam and its salt or tazobactam and its salt. Background technique [0002] Cephalosporin antibiotics have been widely used clinically and played a positive role in human health. At the same time, due to the long-term and extensive clinical use, the problem of bacterial resistance to cephalosporin antibiotics is becoming more and more serious. The main mechanism of bacterial resistance to cephalosporin antibiotics is the production of specific β-lactamases (β-lactmases) to decompose drugs, including chromosome-mediated type I cephalosporinases and plasmid-mediated extended-spectrum β-lactamase. In order to overcome the clinical drug-resistant infection caused by β-lactamase-producing bacteria, it is of great clinical significance to develop compound preparations of cephalosporin antibiotics an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04
Inventor 叶澄海
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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