Anti beta-bactamase antibiotic compound prepn.

Abstract

A compound anti-beta-lactamase antibiotic is prepared from cefuroxime or its salt, sulbactam or its salt, and tazobactan or its salt. Its advantages are broad spectrum and high antibacterial effect.

Description

technical field [0001] The invention relates to an anti-β-lactamase antibiotic compound preparation, in particular to a compound preparation composed of cefuroxime and its salt, sulbactam and its salt or tazobactam and its salt. Background technique [0002] Cephalosporin antibiotics have been widely used clinically and played a positive role in human health. At the same time, due to the long-term and extensive clinical use, the problem of bacterial resistance to cephalosporin antibiotics is becoming more and more serious. The main mechanism of bacterial resistance to cephalosporin antibiotics is the production of specific β-lactamases (β-lactmases) to decompose drugs, including chromosome-mediated type I cephalosporinases and plasmid-mediated extended-spectrum β-lactamase. In order to overcome the clinical drug-resistant infection caused by β-lactamase-producing bacteria, it is of great clinical significance to develop compound preparations of cephalosporin antibiotics an...

AI Technical Summary

Problems solved by technology

At present, there are no reports on the marketing and clinical application of cefuroxime and its salts, sulbactam and its salts, or tazobactam and its salts as new drugs at home and abroad.