Sulfated Polyguluronic Acid Ester and its preparation method and uses

A technology of ancient sugar esters and polyguluronic acid, which is applied in the field of sulfated polysaccharide ancient sugar esters and its preparation, can solve the problems that cannot meet clinical needs, etc.

Active Publication Date: 2004-11-10
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Abstract
  • Description
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Problems solved by technology

However, these drugs are still far from meeting the growing clinical needs.

Method used

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  • Sulfated Polyguluronic Acid Ester and its preparation method and uses
  • Sulfated Polyguluronic Acid Ester and its preparation method and uses

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Embodiment Construction

[0010] Prepare the alginate with water to make a 1-3% uniform glue solution, degrade it with 0.1-1.0M hydrochloric acid in a 70-100°C water bath for 6-10 hours, centrifuge to discard the supernatant, and take the precipitate with dilute sodium hydroxide Dissolve, grade with acid under the condition of pH = 2.85 under stirring conditions, centrifuge the resulting flocculent precipitate, and then carry out secondary acid degradation and pH classification according to the above conditions. Dispersing the obtained precipitate with water, adjusting the pH to dissolve, then performing ultrafiltration to remove small molecules, and then precipitating with 3-4 times the volume of 95% ethanol, dehydrating and drying to obtain polyguluronic acid with high purity. In an ice-water bath, slowly add 10.0 g of polyguluronic acid to 100-150 g of sulfation reagent under stirring conditions, raise the reaction temperature to 60-70°C after addition, and keep the reaction for 1.5-3.5 hours. After...

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Abstract

A polyguluronic acid ester having a chemical name of L-polyguluronic aldonic acid-2, 3-sulfuric acid, is prepared through the steps of first obtaining L-polyguluronic aldonic acid through acid degradation and pH grading of alginic acid, proceeding secondary acid degradation and pH grading, carrying out ultrafiltration, deposition, dewatering and drying, using sulfating agent to subject the polyguluronic acid ester to sulfation, alcohol deposition, scouring, alkaline treatment, filtering, drying and disintegrating. The polyguluronic acid ester according to the invention has strong negative ion concentration property, it can be utilized in the preparation of medicament for treating or preventing urinary lithiasis.

Description

technical field [0001] The invention relates to a polysaccharide, in particular to a sulfated polysaccharide ancient sugar ester and its preparation method and application in anti-urolithiasis. Background technique [0002] Urolithiasis is one of the frequently-occurring diseases that impair people's health and reduce the quality of life. It has a high incidence worldwide. For example, about 10% of people in western countries will visit a doctor once in their lifetime because of urolithiasis. my country is one of the high-incidence areas of stone disease, especially in some areas in southern my country, which accounts for the first place in the number of urology hospitalizations. Another feature of calculus is the high recurrence rate. Foreign studies have shown that the recurrence rate of patients after eight years of treatment is greater than 50%. Studies in my country have shown that the recurrence rate of patients nine years after treatment is about 70%, and the long-te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P13/04C08B37/00
Inventor 管华诗李桂玲赵峡
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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