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Hypercritical carbon dioxide extraction of magnolia bark and fruit of common cnidium composition

A technology of Cnidium chinensis extract and carbon dioxide, which is applied in the directions of medical preparations containing active ingredients, pill delivery, and drug combinations, can solve the problems of adverse reactions, tolerance, and curative effect decline, and achieves stable curative effect and a huge society. Beneficial, less toxic effect

Inactive Publication Date: 2004-11-17
SHENZHEN DONGFANG TAIGE BIOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs all have certain adverse reactions, and long-term use of chemical drugs sometimes produces tolerance and reduces the curative effect, and sometimes it is difficult to be effective due to asthma caused by different etiologies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: (tablet) take the Fructus Cnidii extract of prescription quantity, Magnolia officinalis extract and mix with adjuvant after β-CD, microcrystalline cellulose, starch are solidified, press tablet after wet granulation, obtain final product .

Embodiment 2

[0017] Embodiment 2: (micropills) get the Fructus Cnidii extract of recipe quantity, Magnolia officinalis extract and mix with adjuvant after β-CD, microcrystalline cellulose, starch are solidified, take hypromellose as binding agent , using the blank pellet core as a substrate to prepare pellets with a particle size of 0.4-1.5mm, that is.

Embodiment 3

[0018] Embodiment 3: (granule) get the Fructus Cnidii extract of recipe quantity, Magnolia officinalis extract and mix homogeneously after β-CD, microcrystalline cellulose, starch are solidified, take hypromellose as adhesive wet method system Granules, dry the granules at 30°C to obtain.

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Abstract

The invention relates to a compound preparation of magnolia bark and cnidium fruit hypercritical carbon dioxide extract, which comprises magnolia bark extract, cnidium fruit extract and medicinal auxiliary materials. The invention provides a safe, controllable, stabilized, and effective Chinese preparation for treating asthma. íí

Description

1. Technical field: [0001] The invention relates to the field of medical preparation of traditional Chinese medicines, in particular to a compound preparation of supercritical carbon dioxide extracts of Magnolia officinalis and Fructus Cnidii. 2. Background technology: [0002] Asthma is one of the common chronic diseases in the world. There are about 150 million asthmatics in the world. In the past two decades, the incidence rate in the world has been gradually increasing. It is of great significance to study its treatment. At present, Drugs for treating asthma include: 1. Adrenergic receptor agonists; 2. Antiallergic drugs; 3. Theophylline drugs; 4. Glucocorticoids. However, there are certain adverse reactions in the above-mentioned medicines, and long-term use of chemical medicines may sometimes produce tolerance and reduce curative effect, and sometimes it is difficult to be effective because of asthma caused by different etiologies. Therefore, the research and developm...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/16A61K9/20A61K9/48A61K9/50A61P11/00A61P11/06
Inventor 唐星李卫民
Owner SHENZHEN DONGFANG TAIGE BIOPHARML
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