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Radiation protection composition and preparation method thereof

A technology of radiation protection and composition, which is applied in the field of medicine, can solve problems such as long-term unhealed skin and mucous membrane damage, general SOD stability, and short drug effect time, so as to be beneficial to clinical treatment, suitable for large-scale production, and avoid The effect of a short shelf life

Inactive Publication Date: 2018-08-10
QINGDAO CHENLAND MARINE BIOTECH CO LTD
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AI Technical Summary

Problems solved by technology

[0007] However, the main disadvantages of the current radiation protection products are that after the drug is applied to the radiation field, the drug effect time is short, and frequent medication is required; the skin and mucous membrane damage caused by radiation will not heal for a long time, causing subsequent skin problems, and the stability of SOD is average.

Method used

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  • Radiation protection composition and preparation method thereof

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Effect test

Embodiment 1

[0033] Example 1. Preparation of spray composition with radiation protection function

[0034] (1) Take SOD (activity 12000IU / mg) and dissolve it in PBS buffer, stir and dissolve at 20°C. During the stirring process, the activated lauric acid modifier was added, and then the temperature was raised to 40°C, and the stirring was continued at 40°C for 40 minutes, and then quickly dropped to room temperature. Acetone was added to the solution, the solution was centrifuged at 5000 r / min, and the precipitate was collected. After re-dissolving the precipitate, centrifuge to remove insoluble matter. Then it was dialyzed with distilled water, and the active part of the enzyme was collected with an S-200 chromatography column, and then subjected to dialysis, ultrafiltration, and freeze-drying processes in order to obtain the modified SOD.

[0035] (2) Weigh 0.01g modified superoxide dismutase SOD, 3g polysucrose, 3g sodium alginate, 3g lactose (the ratio of the three parts by mass is 1:1:1...

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Abstract

The invention relates to a medical radiation protection composition and a preparation method and application thereof. The composition is prepared from SOD lyophilized powder and a carotene aqueous solution; the SOD lyophilized powder is lyophilized powder of superoxide dismutase (SOD) modified by lauric acid and an enzyme stabilizer; the carotene aqueous solution is an aqueous solution of potassium sorbate, sorbitol, beta-carotene and purified water. The preparation method comprises the following steps that the (1) the SOD lyophilized powder is prepared; (2) the carotene aqueous solution is prepared; (3) the components in the first and second steps are mixed to obtain the radiation protection composition. The prepared radiation protection composition is high in stability, long in activityduration and long in drug effect time after the composition is applied to a radiation field, and tissue regeneration and healing of skin ulcer wounds can be promoted. According to the medical radiation protection composition and the preparation method and application thereof, a double-cavity mixing bottle is used conveniently, the situation that the composition is short in shelf life by using a single bottle and the operation is complicated by using double bottles is avoided, and the composition is convenient to use and beneficial to clinical treatment.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a medical radiation protection composition and a preparation method thereof. Background technique [0002] When cancer patients receive radiotherapy, medical rays generate a large number of free radicals in the patient's body through ionization. Free radicals are paramagnetic and highly reactive, which can cause normal skin and mucous membranes to have varying degrees of damage effects (such as skin erythema, dry and wet peeling, and skin and mucosal tissue bleeding and erosion). While radiotherapy kills cancer cells, it also causes certain damage to normal tissue cells and brings new pain to patients. Those with severe reactions are forced to interrupt treatment, which affects the survival rate and quality of life of patients. According to reports, the incidence of radiation dermatitis in patients undergoing radiotherapy without any measures is over 90%. The main cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61P17/16A61P39/00A61P17/02A61K31/734A61K31/015
CPCA61K31/015A61K31/734A61K38/446A61P17/02A61P17/16A61P39/00C12Y115/01001A61K2300/00
Inventor 林莎莎贾凯王宝群邹圣灿
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
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