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Medicinal composition with ginseng and gingko leaf effective portion and its preparation mehtod

An effective part, ginkgo biloba technology, applied in medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve problems such as blood vessel rupture and bleeding, and achieve the goal of supporting righteousness, reducing blood vessel rupture, and strengthening the patient's system Effect

Inactive Publication Date: 2005-01-26
北京干露春科技有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

Therefore, Ginkgo biloba, which can treat cardiovascular and cerebrovascular diseases clinically, is widely used in various preparations. However, as more and more Ginkgo biloba preparations are used clinically, many medical workers have found that the effective parts of Ginkgo biloba have many It has a strong effect of promoting blood circulation and removing blood stasis. Long-term application may cause the risk of blood vessel rupture. Especially for elderly patients, the effective part of ginkgo extract can cause bleeding.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Pharmacological Experiments on Bleeding Time and Bleeding Volume in Mice

[0076] Experimental drug: each group of preparations of the present invention (provided by Beijing Ganluchun Technology Co., Ltd.)

[0077] Ginkgo biloba extract (purchased by Beijing Green Jinke Biotechnology Co., Ltd.)

[0078] Normal saline (provided by Beijing Qianluchun Technology Co., Ltd.)

[0079] Experimental animals: Swiss mice were purchased from the Experimental Animal Department of Beijing University of Traditional Chinese Medicine.

[0080] Methods and results: 90 mice, weighing 20±2g, half male and half male, were randomly divided into 9 groups. Each group of preparations of the present invention and Ginkgo biloba extract were administered to mice at 5 g / kg, once a day for 3 consecutive days, and the control group was given an equivalent amount of normal saline (NS). One hour after the last dose of the drug, the mice were driven into a special holder, and the...

Embodiment 2

[0085] The effects of each group of preparations of the present invention and commercially available Mailuoning injection on thrombus formation in rats were determined by thrombus method.

[0086] Experimental drug: normal saline (blank group) was provided by the laboratory of Beijing Qianluchun Technology Co., Ltd.

[0087] Commercially available Mailuoning injection (produced by Nanjing Jinling Pharmaceutical Co., Ltd., purchased from Beijing Baitasi Pharmaceutical Wholesale Company)

[0088] Each group of preparations of the present invention (provided by the laboratory of Beijing Ganluchun Science and Technology Co., Ltd.)

[0089] Experimental animals: 90 white rats weighing 300-400 grams, male or female. Divide into 9 groups, 10 in each group.

[0090] Experimental method: Rats were anesthetized (sodium pentobarbital 30-40mg / kg, ip), fixed in the supine position, the trachea was separated, a plastic cannula was inserted, and the right common carotid artery and the left...

Embodiment 3

[0094] The in vivo myocardial infarction method was used to determine the effects of each group of preparations of the present invention and commercially available Ginkgo Damole injection on myocardial infarction in rats.

[0095] Experimental drug: commercially available Ginkgo Damo injection (produced by Nanjing Jinling Pharmaceutical Co., Ltd. and purchased from Beijing Baitasi Pharmaceutical Wholesale Company).

[0096] Each group of preparations of the present invention (provided by the laboratory of Beijing Ganluchun Science and Technology Co., Ltd.)

[0097] Experimental animals: 90 male rats weighing 250-300 grams, divided into 9 groups.

[0098] Experimental method: Take 20 male rats, after light abdominal anesthesia with urethane 0.65g / kg, fix the dorsal position, use more than half of a rubber ball to connect to the artificial respirator, and perform artificial respiration. Incise the skin at the midclavian line about 2 cm, bluntly dissect the base layer of the fou...

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Abstract

The invention provides a medicinal composition with ginseng and gingko leaf effective portion and its preparation method, characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal ginkgo leaves and other medical use findings.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical composition containing effective parts of ginseng and ginkgo leaves and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases kill 12 million people every year, close to 1 / 4 of the total number of deaths in the world, and become the number one enemy of human health. Dr. Nakajima Hiroshi, Director-General of the World Health Organization (WHO), said: "In today's world Cardiovascular and cerebrovascular disease kills more people and disables millions more than any other disease." Although the mortality rate of cardiovascular and cerebrovascular diseases has declined to varying degrees in most countries except Eastern European countries in the past 30 years, it is still the first cause of death in men over 45 years old in most countries, and it is second only to tumors in wom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16A61P9/00A61P9/10
Inventor 张晴龙
Owner 北京干露春科技有限公司
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