The invention discloses a medicinal liquor and specially relates to a medicinal liquor with a health care effect and a manufacturing method thereof. The medicinal liquor is composed of liquor and soaked medicinal materials. The medicinal materials comprise milkvetch root, fortune's drynaria rhizome, white peony root, air potato, Chinese angelica, unprocessed rehmannia root, Shenguzhi, Weisijie, cibotium rhizome, banksia rose, red sage root, pseudo-ginseng, Himalayan teasel root, Sichuan lovage rhizome, Jianglan, sappan wood, eucommia, peach seed, spatholobus stem, kusnezoff monkshood root, dark plum, combined spicebush root, rhubarb root and rhizome, cornu cervi, earthworm, barbary wolfberry fruit, root of kudzu vine, licorice, pawpaw, clematis root, achyranthes root, madder, frankincense, myrrh, safflower and honeysuckle flower. According to the invention, since a great variety and a complete range of medicinal materials are selected and used, the processed medicinal liquor can perform maximum drug efficacy so as to achieve the effects of promoting blood circulation to remove blood stasis and strengthening tendons and bones, and cost is saved, thereby overcoming the problem of cost waste caused by the fact that maximum drug efficacy is not obtained under the condition of usage of excessive amount of expensive medicinal materials; and the medicinal liquor can exert a good health care effect after people drinking the medicinal liquor.