Bicarbonate hemodialysis agent without acetic acid

A technology of bicarbonate and dialysis agent, applied in the field of hemodialysis agent, can solve the problems of high price of glycylglycine, restricting the widespread use, etc., and achieve the effects of protecting normal cells and residual renal function, low price, and overcoming adverse effects.

Active Publication Date: 2005-07-06
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glycylglycine is expensive, which restricts its widespread clinical use

Method used

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  • Bicarbonate hemodialysis agent without acetic acid

Examples

Experimental program
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Effect test

example 1

[0044] 1. Example 1: A component sodium chloride (NaCl) 1610g

[0045] Potassium chloride (KCl) 41.2g

[0046] Calcium Chloride (CaCl 2 2H 2 O) 97.0g

[0047] Magnesium Chloride (MgCl 2 ·6H 2 O) 59.9g

[0048] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 197.2g

[0049] B component sodium bicarbonate (NaHCO 3 ) 660.1g

[0050] Sodium chloride (NaCl) 304.9g

[0051] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0052] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0053] 139.7 1.5 1.8 0.8 112.2 4.8 39.0

example 2

[0054] 2. Example 2: A component sodium chloride (NaCl) 2168.1g

[0055] Potassium chloride (KCl) 78.3g

[0056] Calcium Chloride (CaCl 2 2H 2 O) 77.2g

[0057] Magnesium Chloride (MgCl 2 ·6H 2 O) 24.9g

[0058] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 97.6g

[0059] B component sodium bicarbonate (NaHCO 3 ) 700g

[0060] Sodium chloride (NaCl) 0

[0061] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.26:32.74 on the machine, and the final concentration of each ion (mmol / L) is:

[0062] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0063] 136 3.0 1.5 0.35 115.2 2.5 30.0

example 3

[0064] 3. Example 3: A component sodium chloride (NaCl) 1721.9g

[0065] Potassium chloride (KCl) 41.2g

[0066] Calcium Chloride (CaCl 2 2H 2 O) 81.2g

[0067] Magnesium Chloride (MgCl 2 ·6H 2 O) 37.5g

[0068] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 123.2g

[0069] B component sodium bicarbonate (NaHCO 3 ) 659g

[0070] Sodium chloride (NaCl) 282g

[0071] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0072] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0073] 143 1.5 1.5 0.5 112.5 3.0 39.0

[0074] Get the formula of embodiment 3 and carry out stability test (accelerate 6 months and keep sample for a long time...

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Abstract

The invention relates to an acetate acid free hemodialysis agent of bicarbonate. The hemodialysis agent is composed of constituent A and constituent B, constituent A: sodium chloride 77%-94%, potassium chloride 0%-4%, calcium chloride 2%-6%, magnesium chloride 1%-3%, glycine hydrochloride 3%-10%. constituent B: sodium bicarbonate 65%-100%, sodium chloride 0%-35%.

Description

technical field [0001] The invention relates to a hemodialysis agent in blood purification treatment, in particular to a bicarbonate hemodialysis agent including solid and liquid formulations. Background technique [0002] Currently commonly used bicarbonate hemodialysis preparations are divided into two components, A and B. The A component is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), component B is composed of sodium bicarbonate (NaHCO 3 ) or combined with sodium chloride (NaCl). Before use, the solid preparation needs to be dissolved into a solution (concentrate) with purified water according to regulations; the liquid preparation can be used directly for hemodialysis. When in use, the hemodialysis machine absorbs liquid A, liquid B and water respectively in proportion, and automatically mixes them in the machine to form a dialysate, and then performs hemodialysis on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/14
Inventor 黎春罗建明周卫芬司徒少金
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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