Bicarbonate hemodialysis agent without acetic acid

A technology of bicarbonate and dialysis agent, applied in the field of hemodialysis agent, can solve the problems of high price of glycylglycine, restricting the widespread use, etc., and achieve the effects of protecting normal cells and residual renal function, low price, and overcoming adverse effects.

A technology of bicarbonate and dialysis agent, applied in the field of hemodialysis agent, can solve the problems of high price of glycylglycine, restricting the widespread use, etc., and achieve the effects of protecting normal cells and residual renal function, low price, and overcoming adverse effects.

CN1634614AActive Publication Date: 2005-07-06GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Bicarbonate hemodialysis agent without acetic acid

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Experimental program
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example 1

[0044] 1. Example 1: A component sodium chloride (NaCl) 1610g

[0045] Potassium chloride (KCl) 41.2g

[0046] Calcium Chloride (CaCl 2 2H 2 O) 97.0g

[0047] Magnesium Chloride (MgCl 2 ·6H 2 O) 59.9g

[0048] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 197.2g

[0049] B component sodium bicarbonate (NaHCO 3 ) 660.1g

[0050] Sodium chloride (NaCl) 304.9g

[0051] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0052] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0053] 139.7 1.5 1.8 0.8 112.2 4.8 39.0

example 2

[0054] 2. Example 2: A component sodium chloride (NaCl) 2168.1g

[0055] Potassium chloride (KCl) 78.3g

[0056] Calcium Chloride (CaCl 2 2H 2 O) 77.2g

[0057] Magnesium Chloride (MgCl 2 ·6H 2 O) 24.9g

[0058] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 97.6g

[0059] B component sodium bicarbonate (NaHCO 3 ) 700g

[0060] Sodium chloride (NaCl) 0

[0061] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.26:32.74 on the machine, and the final concentration of each ion (mmol / L) is:

[0062] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0063] 136 3.0 1.5 0.35 115.2 2.5 30.0

example 3

[0064] 3. Example 3: A component sodium chloride (NaCl) 1721.9g

[0065] Potassium chloride (KCl) 41.2g

[0066] Calcium Chloride (CaCl 2 2H 2 O) 81.2g

[0067] Magnesium Chloride (MgCl 2 ·6H 2 O) 37.5g

[0068] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 123.2g

[0069] B component sodium bicarbonate (NaHCO 3 ) 659g

[0070] Sodium chloride (NaCl) 282g

[0071] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0072] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0073] 143 1.5 1.5 0.5 112.5 3.0 39.0

[0074] Get the formula of embodiment 3 and carry out stability test (accelerate 6 months and keep sample for a long time...

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Abstract

The invention relates to an acetate acid free hemodialysis agent of bicarbonate. The hemodialysis agent is composed of constituent A and constituent B, constituent A: sodium chloride 77%-94%, potassium chloride 0%-4%, calcium chloride 2%-6%, magnesium chloride 1%-3%, glycine hydrochloride 3%-10%. constituent B: sodium bicarbonate 65%-100%, sodium chloride 0%-35%.

Description

technical field [0001] The invention relates to a hemodialysis agent in blood purification treatment, in particular to a bicarbonate hemodialysis agent including solid and liquid formulations. Background technique [0002] Currently commonly used bicarbonate hemodialysis preparations are divided into two components, A and B. The A component is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), component B is composed of sodium bicarbonate (NaHCO 3 ) or combined with sodium chloride (NaCl). Before use, the solid preparation needs to be dissolved into a solution (concentrate) with purified water according to regulations; the liquid preparation can be used directly for hemodialysis. When in use, the hemodialysis machine absorbs liquid A, liquid B and water respectively in proportion, and automatically mixes them in the machine to form a dialysate, and then performs hemodialysis on...

Claims

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Application Information

Patent Timeline
06 Jul 2005
Publication
CN1634614A
IPC
A61M1/14
Inventors
黎春; 罗建明